Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Roman Davis"'
Autor:
B. Liu, Vassil I. Elitzin, J. Powers, Daniel E. Patterson, Roman Davis, Elie Amine Tabet, Chong Pek Yoke, Matthew Salmons, M. Toczko, Mark A. Hatcher, Kae M. Bullock, M. Jackson
Publikováno v:
Topics in Catalysis. 55:446-452
Transition metal catalysis by Cu (CF3Cu), Ir (C–H activation), and Ru (ring-closing metathesis) were applied to prepare a complicated tetra substituted pyrazolopyridine drug candidate at GlaxoSmithKline. CuI/FSO2CF2CO2Me was utilized to install a C
Autor:
Richard T. Matsuoka, Svetlana A. Burova, Russ N. Fitzgerald, David J. Burinsky, Byron S. Johnson, Roman Davis
Publikováno v:
Rapid Communications in Mass Spectrometry. 26:1115-1122
RATIONALE The 2-aminoaniline scaffold is of significant value to the pharmaceutical industry and is embedded in a number of pharmacophores including 2-aminoanilides and benzimidazoles. A novel application of coordination ion spray mass spectrometry (
Publikováno v:
Organic Process Research & Development. 14:712-715
Parallel microreactor screening enabled rapid identification of effective conditions for PTC-mediated Knoevenagel condensation between aldehyde (1) and thiazalone (2), affording a dramatic reduction in cycle time when compared to traditional conditio
Autor:
Shannon Condon, Andrew J. Hazelwood, Roman Davis, Elie A. Tabet, Ben Andrews, John Grimes, John Corona, Kae M. Bullock
Publikováno v:
Synthetic Communications. 39:2664-2673
Friedel–Crafts cyclization products were obtained using 1.1 equivalents of environmentally benign trichloroacetic anhydride as sole reagent and solvent. The resulting ketones included benzothiepins, benzothiopyrans, benzoxepins, dibenzothiepins, di
Autor:
Roman Davis, Andrew D. Brown, Matthew J. Sharp, Bing Liu, Bobby N. Glover, Russ N. Fitzgerald, Lynda A. Jones, Kim A. Harvey, Daniel E. Patterson
Publikováno v:
Organic Process Research & Development. 13:297-302
Three efficient syntheses of sodelglitazar (1) have been developed. In particular, the third synthesis avoids the use of zinc and eliminates the resulting heavy metal waste stream as well as the potential genotoxic methanesulfonate in the two earlier
Autor:
Alan Millar, Jennifer F. Toczko, David M. Black, Tom C. Lovelace, Shiping Xie, Brian D. Doan, Roman Davis
Publikováno v:
Tetrahedron: Asymmetry. 19:2015-2019
An efficient highly diastereo- and enantioselective synthesis of the bis-tetrahydrofuran (bis-THF) alcohol of several HIV protease inhibitors, including Brecanavir and Darunavir, has been achieved utilizing an Evans Mukaiyama aldol reaction of (benzy
Publikováno v:
Synthetic Communications. 37:3029-3039
A novel method for preparation of 1‐substituted benzimidazoles via reductive amination of ketones with N‐differentiated 1,2‐diaminobenzenes is described. The method appears to be general in application to acyclic and cyclic ketones, as well as
Publikováno v:
Synthetic Communications. 36:2129-2133
An improved, two‐step synthesis of efaproxiral, used in breast cancer therapy, is described, utilizing inexpensive commodity chemicals for starting materials. Selective amide formation and O‐alkylation in the presence of multireactive functional
Publikováno v:
Synthesis. 2004:1959-1962
An improved method for the formation of 2-methyl-2-aryloxypropanoic acid derivatives, an important class of compounds for the potential treatment of type II diabetes, is reported. This method offers several advantages over the existing chemistry for
Autor:
Chong Pek Yoke, Mark A. Hatcher, Elie Amine Tabet, Vassil I. Elitzin, Roman Davis, Matthew Salmons, Bing Liu
Publikováno v:
Tetrahedron Letters. 53:6786-6788
Two syntheses of 7-trifluoromethylpyrazolo[1,5-a]pyridine dicarboxylate have been described. Approach A utilizes a nucleophilic addition of a trifluoromethyl group to N-p-toluenesulfonyliminopyridinium ylide followed by aromatization and subsequent c