Gabapentin for chronic pelvic pain in women (GaPP2):a multicentre, randomised, double-blind, placebo-controlled trial

Autor: Andrew W Horne, Katy Vincent, Catherine A Hewitt, Lee J Middleton, Magda Koscielniak, Wojciech Szubert, Ann M Doust, Jane P Daniels, Suraiya Abdi, Santanu Acharya, Shamma Al-Inizi, Elizabeth Ball, Andrew Baranowski, Nadia Bhal, Kalsang Bhatia, Siladitya Bhattacharya, Judy V. Birch, Tyrone Carpenter, Tony Chalhoub, Ying C. Cheong, T. Justin Clark, Roman Cregg, Tunde D. Dada, Dib Datta, Radwan Faraj, Max G. Feltham, Pratima Gupta, Dharani Hapangama, Chris Hardwick, Jon Hughes, Pinky Khatri, Geeta Kumar, Lisa J. Leighton, Kingshuk Majumder, Gary J. MacFarlane, Alex Mortimer, Smita Odedra, Bruce Ramsay, Amer Raza, William Rea, Somendra Roy, Afia Sajid, Lucky Saraswat, Ahmar Shah, Jambulingam Sivasamy, Rashmi Srivastava, Clive Stubbs, Ajay Swaminathan, Premila Thampi, Omar Thanoon, Tony Thomas, Irene Tracey, Martyn Underwood, Clare Willocks, Amanda C de C. Williams, Simon Wood, Krina Zondervan

Publikováno v: Horne, A W, Vincent, K, Hewitt, C A, Middleton, L J, Koscielniak, M, Szubert, W & Doust, A M & Daniels, J P 2020, ' Gabapentin for chronic pelvic pain in women (GaPP2) : a multicentre, randomised, double-blind, placebo-controlled trial ', The Lancet, vol. 396, no. 10255, pp. 909-917 . https://doi.org/10.1016/S0140-6736(20)31693-7
Lancet (London, England)
Horne, A W, Vincent, K, Hewitt, C A, Middleton, L J, Koscielniak, M, Szubert, W, Doust, A M, Daniels, J P, Abdi, S, Acharya, S, Al-inizi, S, Ball, E, Baranowski, A, Bhal, N, Bhatia, K, Bhattacharya, S, Birch, J V, Carpenter, T, Chalhoub, T, Cheong, Y C, Clark, T J, Cregg, R, Dada, T D, Datta, D, Faraj, R, Feltham, M G, Gupta, P, Hapangama, D, Hardwick, C, Hughes, J, Khatri, P, Kumar, G, Leighton, L J, Majumder, K, Macfarlane, G J, Mortimer, A, Odedra, S, Ramsay, B, Raza, A, Rea, W, Roy, S, Sajid, A, Saraswat, L, Shah, A, Sivasamy, J, Srivastava, R, Stubbs, C, Swaminathan, A, Thampi, P & Thanoon, O 2020, ' Gabapentin for chronic pelvic pain in women (GaPP2): a multicentre, randomised, double-blind, placebo-controlled trial ', The Lancet, vol. 396, no. 10255, pp. 909-917 . https://doi.org/10.1016/S0140-6736(20)31693-7

© 2020 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 license Background: Chronic pelvic pain affects 2–24% of women worldwide and evidence for medical treatments is scarce. Gabapentin is effective in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49677b67c9c6bbfa393d304853306cdd
https://hdl.handle.net/20.500.11820/2deb1cb7-3cd5-4fad-a3d9-77b7d6d67b4e

GaPP2, a multicentre randomised controlled trial of the efficacy of gabapentin for the management of chronic pelvic pain in women:study protocol

Autor: Catherine A Hewitt, Siladitya Bhattacharya, Gary J. Macfarlane, Wojciech Szubert, Amanda C de C Williams, Judy Birch, Jane P Daniels, Lee J Middleton, Katy Vincent, Ying Cheong, Andrew W Horne, Roman Cregg, Andrew P. Baranowski, Irene Tracey

Publikováno v: Vincent, K, Baranowski, A, Bhattacharya, S, Birch, J, Cheong, Y C, Cregg, R, Daniels, J P, Hewitt, C A, Macfarlane, G J, Middleton, L J, Szubert, W, Tracey, I, de C Williams, A C & Horne, A W 2018, ' GaPP2, a multicentre randomised controlled trial of the efficacy of gabapentin for the management of chronic pelvic pain in women : study protocol ', BMJ Open, vol. 8, no. 1, pp. e014924 . https://doi.org/10.1136/bmjopen-2016-014924
BMJ Open

IntroductionChronic pelvic pain (CPP) affects more than 1 million UK women with associated healthcare costs of £158 million annually. Current evidence supporting interventions when no underlying pathology is identified is very limited and treatment

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c20f1991948803ee562a63190c067602
https://www.pure.ed.ac.uk/ws/files/54486388/e014924.full.pdf

Persistent postsurgical pain

Autor: Roman Cregg, Paul Farquhar-Smith, Sibtain Anwar

Publikováno v: Current Opinion in Supportive & Palliative Care. 7:144-152

Persistent postsurgical pain (PPP) is an important cause of pain morbidity following surgery for almost any cause, but there is a greater evidence base for pain after cancer surgery. Historically, both patients and practitioners have struggled to rec

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https://doi.org/10.1097/spc.0b013e328360b09e

Performance on a probabilistic inference task in healthy subjects receiving ketamine compared with patients with schizophrenia

Autor: Imrat Sohanpal, Bruno B. Averbeck, Tracey Collier, Sukhi Shergill, Pervez Sultan, Basil Almahdi, Simon Evans, Brigitta Brandner, Roman Cregg

Publikováno v: Journal of Psychopharmacology (Oxford, England)

Evidence suggests that some aspects of schizophrenia can be induced in healthy volunteers through acute administration of the non-competitive NMDA-receptor antagonist, ketamine. In probabilistic inference tasks, patients with schizophrenia have been

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b789b1e73610228f5cefef5e25ef15a
https://doi.org/10.1177/0269881111435252

Pain channelopathies

Autor: Aliakmal Momin, Roman Cregg, Jing Zhao, Francois Rugiero, John N. Wood

Publikováno v: The Journal of Physiology. 588:1897-1904

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ce8a535ec570ad32ad849e228ccdb21b
https://doi.org/10.1113/jphysiol.2010.187807