Zobrazeno 1 - 10
of 33
pro vyhledávání: '"Roman Camarda"'
Autor:
Lauren R. Begg, Adrienne M. Orriols, Markella Zannikou, Chen Yeh, Pranathi Vadlamani, Deepak Kanojia, Rosemary Bolin, Sara F. Dunne, Sanjeev Balakrishnan, Roman Camarda, Diane Roth, Nicolette A. Zielinski-Mozny, Christina Yau, Athanassios Vassilopoulos, Tzu-Hsuan Huang, Kwang-Youn A. Kim, Dai Horiuchi
Publikováno v:
Communications Medicine, Vol 4, Iss 1, Pp 1-17 (2024)
Abstract Background Understanding why some triple-negative breast cancer (TNBC) patients respond poorly to existing therapies while others respond well remains a challenge. This study aims to understand the potential underlying mechanisms distinguish
Externí odkaz:
https://doaj.org/article/bbe12d3b38a147d5bf67e56921985ad3
Autor:
Taekyu Kang, Christina Yau, Christopher K. Wong, John Z. Sanborn, Yulia Newton, Charlie Vaske, Stephen C. Benz, Gregor Krings, Roman Camarda, Jill E. Henry, Josh Stuart, Mark Powell, Christopher C. Benz
Publikováno v:
Breast Cancer Research, Vol 22, Iss 1, Pp 1-15 (2020)
Abstract Background Previous studies have identified and validated a risk-associated Active transcriptome phenotype commonly expressed in the cancer-adjacent and histologically normal epithelium, stroma, and adipose containing peritumor microenvironm
Externí odkaz:
https://doaj.org/article/9cb4b8d3adf64473892c5bed9de4b6cb
Autor:
Julia Rohrberg, Daniel Van de Mark, Meelad Amouzgar, Joyce V. Lee, Moufida Taileb, Alexandra Corella, Seda Kilinc, Jeremy Williams, Marie-Lena Jokisch, Roman Camarda, Sanjeev Balakrishnan, Rama Shankar, Alicia Zhou, Aaron N. Chang, Bin Chen, Hope S. Rugo, Sophie Dumont, Andrei Goga
Publikováno v:
Cell Reports, Vol 30, Iss 10, Pp 3368-3382.e7 (2020)
Summary: Tumors that overexpress the MYC oncogene are frequently aneuploid, a state associated with highly aggressive cancers and tumor evolution. However, how MYC causes aneuploidy is not well understood. Here, we show that MYC overexpression induce
Externí odkaz:
https://doaj.org/article/2a58f33465c64c2095456ecd5652ebd7
Autor:
Dvir Aran, Roman Camarda, Justin Odegaard, Hyojung Paik, Boris Oskotsky, Gregor Krings, Andrei Goga, Marina Sirota, Atul J. Butte
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
Normal tissue adjacent to the tumour (NAT) is often used as a control in cancer studies. Here, the authors analyse across cancer types the transcriptomes of healthy, NAT, and tumour tissues, and find that NAT presents a unique state, potentially due
Externí odkaz:
https://doaj.org/article/92442fbf71dc46038ab5ef9c6bf555db
Publikováno v:
PLoS Pathogens, Vol 8, Iss 8, p e1002866 (2012)
Like cancer cells, virally infected cells have dramatically altered metabolic requirements. We analyzed global metabolic changes induced by latent infection with an oncogenic virus, Kaposi's Sarcoma-associated herpesvirus (KSHV). KSHV is the etiologi
Externí odkaz:
https://doaj.org/article/15ab9df983bd403baa1df37f30ccd89a
Autor:
Taekyu Kang, Christopher C. Benz, Christopher K. Wong, Yulia Newton, Roman Camarda, Charles J. Vaske, Josh Stuart, Jill E. Henry, Gregor Krings, Stephen C. Benz, Christina Yau, Mark Powell
Publikováno v:
Cancer Research. 80:P3-08
Background: Previous studies of breast samples from cosmetic surgeries, benign biopsies associated with abnormal mammograms or cancer-adjacent tissue have identified at least two different transcriptional phenotypes of “normal” human breast tissu
Autor:
Rebekka Paisner, Suprit Gupta, Seda Kilinc, Rushika M. Perera, Rebecca A. Kohnz, Noelle D. L'Etoile, Daniel K. Nomura, Roman Camarda, Olga Momcilovic, Andrei Goga, Baris Avsaroglu
Publikováno v:
Dev Cell
Developmental cell, vol 56, iss 13
Developmental cell, vol 56, iss 13
Oncogenes can alter metabolism by changing the balance between anabolic and catabolic processes. However, how oncogenes regulate tumor cell biomass remains poorly understood. Using isogenic MCF10A cells transformed with nine different oncogenes, we s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be39ec3d0173ae436688a8c380e33c9a
https://europepmc.org/articles/PMC8292920/
https://europepmc.org/articles/PMC8292920/
Autor:
Julia Rohrberg, Seda Kilinc, Alicia Y. Zhou, An Chang, H Klein-Connolly, M-L Jokisch, Andrei Goga, Roman Camarda, Sanjeev Balakrishnan, Moufida Taileb, Alexandra Corella
Publikováno v:
Cancer Research. 79:P3-09
Tumors that overexpress the MYC oncogene, including most receptor triple-negative breast cancers, frequently demonstrate aneuploidy, numerical chromosome alterations associated with highly aggressive cancers. Aneuploidy is also associated with rapid
Autor:
Daniel K. Nomura, Andrei Goga, Seda Kilinc, Rushika M. Perera, Rebecca A. Kohnz, Olga Momcilovic, Rebekka Paisner, Noelle D. L'Etoile, Roman Camarda
Oncogenes can alter cellular structure, function, development and metabolism including changing the balance between anabolic and catabolic processes. However, how oncogenes regulate tumor cell biomass remains poorly understood. Using isogenic mammary
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4681fc891d82a9c8541877f830f4c163
Autor:
Andrei Goga, Rebecca S. Levin, Khyati N. Shah, Roman Camarda, Sourav Bandyopadhyay, Nora Bayani, Kevan M. Shokat, James T. Webber, Olga Momcilovic, John D. Gordan, James E. Korkola, Hayley J. Donnella
Publikováno v:
Nature chemical biology, vol 14, iss 8
Nature chemical biology
Nature chemical biology
Dysregulation of the PI3K-AKT-mTOR signaling network is a prominent feature of breast cancers. However, clinical responses to drugs targeting this pathway have been modest, possibly because of dynamic changes in cellular signaling that drive resistan