Zobrazeno 1 - 10 of 14 pro vyhledávání: '"Roman Belle"'
1
Akademický článek
Reading and erasing of the phosphonium analogue of trimethyllysine by epigenetic proteins
Autor: Roman Belle, Jos J. A. G. Kamps, Jordi Poater, Kiran Kumar, Bas J. G. E. Pieters, Eidarus Salah, Timothy D. W. Claridge, Robert S. Paton, F. Matthias Bickelhaupt, Akane Kawamura, Christopher J. Schofield, Jasmin Mecinović
Publikováno v: Communications Chemistry, Vol 5, Iss 1, Pp 1-11 (2022)
N ε-methylation of lysine residues in histones plays an essential role in the regulation of eukaryotic transcription, and understanding the extent to which histone N ε-methyllysine readers and erasers can manifest selectivity is of fundamental and
Externí odkaz: https://doaj.org/article/099bbfd2e1894d158c026e859ca05b14
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2
Akademický článek
The Role of Electrostatic Interactions in Binding of Histone H3K4me2/3 to the Sgf29 Tandem Tudor Domain.
Autor: Bas J G E Pieters, Erik Meulenbroeks, Roman Belle, Jasmin Mecinović
Publikováno v: PLoS ONE, Vol 10, Iss 9, p e0139205 (2015)
Several reader domain proteins that specifically recognize methyllysine-containing histones contain the negatively-charged aspartate or glutamate residues as part of the aromatic cage. Herein, we report thermodynamic analyses for the recognition of h
Externí odkaz: https://doaj.org/article/2c6d4a93c3ac4679ac5bd55c483aa98f
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3
Expanding the chemical functionality of DNA nanomaterials generated by rolling circle amplification
Autor: Tom Brown, Ysobel R Baker, Roman Belle, Afaf H. El-Sagheer, Robert Carlisle, Jinfeng Chen, Liyiwen Yuan
Publikováno v: Nucleic Acids Research
Rolling circle amplification (RCA) is a powerful tool for the construction of DNA nanomaterials such as hydrogels, high-performance scaffolds and DNA nanoflowers (DNFs), hybrid materials formed of DNA and magnesium pyrophosphate. Such DNA nanomateria
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95f4cc0dedac21def66540346e8e6566
https://ora.ox.ac.uk/objects/uuid:dd15d56b-5b13-49f6-85dd-b22367616d41
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4
Dual LSD1 and HDAC6 Inhibition Induces Doxorubicin Sensitivity in Acute Myeloid Leukemia Cells
Autor: Ipek Bulut, Adam Lee, Buse Cevatemre, Dusan Ruzic, Roman Belle, Akane Kawamura, Sheraz Gul, Katarina Nikolic, A. Ganesan, Ceyda Acilan
Publikováno v: Cancers
Cancers; Volume 14; Issue 23; Pages: 6014
Defects in epigenetic pathways are key drivers of oncogenic cell proliferation. We developed a LSD1/HDAC6 multitargeting inhibitor (iDual), a hydroxamic acid analogue of the clinical candidate LSD1 inhibitor GSK2879552. iDual inhibits both targets wi
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d04b63a397ec41eaed8a5bd9c9e51f98
https://farfar.pharmacy.bg.ac.rs/handle/123456789/4340
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5
Thioether Macrocyclic Peptides Selected against TET1 Compact Catalytic Domain Inhibit TET1 Catalytic Activity
Autor: Roman Belle, Kazuharu Hanada, Kosuke Nishio, Noboru Ohsawa, Hiroaki Suga, Takayuki Katoh, Akane Kawamura, Mikako Shirouzu, Toru Sengoku, Shigeyuki Yokoyama
Publikováno v: ChemBioChem
The ten-eleven translocation (TET) protein family, consisting of three isoforms (TET1/2/3), have been found in mammalian cells and have a crucial role in 5-methylcytosine demethylation in genomic DNA through the catalysis of oxidation reactions assis
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cfef23544b0eb4396de23046d4e39f0b
https://doi.org/10.1002/cbic.201800047
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6
Recognition of shorter and longer trimethyllysine analogues by epigenetic reader proteins
Autor: F. Matthias Bickelhaupt, Peter Betlem, Roman Belle, Robert S. Paton, Jasmin Mecinović, Abbas H. K. Al Temimi, Kiran Kumar, Jordi Poater, Bas J. G. E. Pieters
Publikováno v: Chemical Communications, 54(19), 2409-2412. Royal Society of Chemistry
Chemical Communications, 54, 19, pp. 2409-2412
Chemical Communications
Al Temimi, A H K, Belle, R, Kumar, K, Poater, J, Betlem, P, Pieters, B J G E, Paton, R S, Bickelhaupt, F M & Mecinović, J 2018, ' Recognition of shorter and longer trimethyllysine analogues by epigenetic reader proteins ', Chemical Communications, vol. 54, no. 19, pp. 2409-2412 . https://doi.org/10.1039/c8cc01009a
Chemical Communications, 54, 2409-2412
Histone Nϵ-lysine methylation is a widespread posttranslational modification that is specifically recognised by a diverse class of Nϵ-methyllysine binding reader proteins. Combined thermodynamic data, molecular dynamics simulations, and quantum che
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a5eb982eef2c7853ae56be0a77fee8b
https://research.vu.nl/en/publications/3c04558c-15c1-4374-a9f4-9458c0dadb12
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7
Investigating D-lysine stereochemistry for epigenetic methylation, demethylation and recognition
Autor: Akane Kawamura, Roman Belle, James E. Dunford, Christopher J. Schofield, Udo Oppermann, Tom Brown, Jasmin Mecinović, Catrine Johansson, Kiran Kumar, Al Temimi Ahk., Richard J. Hopkinson, Pieters Bjge., Robert S. Paton, Anthony Tumber
Publikováno v: Chemical Communications, 53, 99, pp. 13264-13267
Chemical Communications, 53, 13264-13267
Chemical Communications
Histone lysine methylation is regulated by Nε-methyltransferases, demethylases, and Nε-methyl lysine binding proteins. Thermodynamic, catalytic and computational studies were carried out to investigate the interaction of three epigenetic protein cl
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32311f0ea9a4d4b9ed175b875f43e7c9
https://hdl.handle.net/2066/181125
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8
Enantioselective Allylation of Selectedortho-Substituted Benzaldehydes: A Comparative Study
Autor: Robert Betík, Martin Kotora, Aneta Kadlčíková, Filip Hessler, Roman Belle
Publikováno v: European Journal of Organic Chemistry. 2014:7245-7252
We report a systematic study of the allylation of ortho-substituted benzaldehydes under catalysis of a Lewis base (N,N-dioxide), a Lewis acid (Keck allylation), and a Bronsted acid. ortho-Halobenzaldehydes were used as the aldehydic substrates, and s
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a8c09c18317d3408944fa786bef7bafd
https://doi.org/10.1002/ejoc.201403034
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10
The Role of Electrostatic Interactions in Binding of Histone H3K4me2/3 to the Sgf29 Tandem Tudor Domain
Autor: Erik Meulenbroeks, Roman Belle, Jasmin Mecinović, Bas J. G. E. Pieters
Publikováno v: PLoS ONE
PLoS ONE, Vol 10, Iss 9, p e0139205 (2015)
PLoS One, 10, 9
PLoS One, 10
Several reader domain proteins that specifically recognize methyllysine-containing histones contain the negatively-charged aspartate or glutamate residues as part of the aromatic cage. Herein, we report thermodynamic analyses for the recognition of h
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6f3f08eec8a476a0f74ee45c8c1b20e
https://pubmed.ncbi.nlm.nih.gov/26421618
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