Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Roman Barth"'
Autor:
Roman Barth, Biswajit Pradhan, Eugene Kim, Iain F. Davidson, Jaco van der Torre, Jan-Michael Peters, Cees Dekker
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-11 (2023)
Abstract DNA loop extrusion by structural-maintenance-of-chromosome (SMC) complexes has emerged as a primary organizing principle for chromosomes. The mechanism by which SMC motor proteins extrude DNA loops is still unresolved and much debated. The r
Externí odkaz:
https://doaj.org/article/12547bab05c54d948ad59bec6503ca6b
Autor:
Roman Barth, Biswajit Pradhan, Eugene Kim, Iain F. Davidson, Jaco van der Torre, Jan‑Michael Peters, Cees Dekker
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-3 (2023)
Externí odkaz:
https://doaj.org/article/c173b80b0c254e0184a119d15c898acc
Autor:
Roman Barth, Haitham A. Shaban
Publikováno v:
Nucleus, Vol 13, Iss 1, Pp 194-202 (2022)
Gene transcription by RNA polymerase II (RNAPol II) is a tightly regulated process in the genomic, temporal, and spatial context. Recently, we have shown that chromatin exhibits spatially coherently moving regions over the entire nucleus, which is en
Externí odkaz:
https://doaj.org/article/cdbce1d12381422cbfe393ff83002b11
Navigating the crowd: visualizing coordination between genome dynamics, structure, and transcription
Publikováno v:
Genome Biology, Vol 21, Iss 1, Pp 1-18 (2020)
Abstract The eukaryotic genome is hierarchically structured yet highly dynamic. Regulating transcription in this environment demands a high level of coordination to permit many proteins to interact with chromatin fiber at appropriate sites in a timel
Externí odkaz:
https://doaj.org/article/cab4827d8b4e41a4bb1f3337b6e83897
Publikováno v:
Genome Biology, Vol 21, Iss 1, Pp 1-21 (2020)
Abstract Bulk chromatin motion has not been analyzed at high resolution. We present Hi-D, a method to quantitatively map dynamics of chromatin and abundant nuclear proteins for every pixel simultaneously over the entire nucleus from fluorescence imag
Externí odkaz:
https://doaj.org/article/d800e063a27a424f87e183cb1eed821c
Publikováno v:
Nucleus, Vol 11, Iss 1, Pp 83-98 (2020)
Chromatin ‘blobs’ were recently identified by live super-resolution imaging of labeled nucleosomes as pervasive but fleeting structural entities. However, the mechanisms leading to the formation of these blobs and their functional implications ar
Externí odkaz:
https://doaj.org/article/b76fefba520a43ff818db4de84fcf1a3
Publikováno v:
Annual Review of Biochemistry. 92
SMC (structural maintenance of chromosomes) protein complexes are an evolutionarily conserved family of motor proteins that hold sister chromatids together and fold genomes throughout the cell cycle by DNA loop extrusion. These complexes play a key r
Autor:
Iain F. Davidson, Roman Barth, Maciej Zaczek, Jaco van der Torre, Wen Tang, Kota Nagasaka, Richard Janissen, Jacob Kerssemakers, Gordana Wutz, Cees Dekker, Jan-Michael Peters
Publikováno v:
Nature: international weekly journal of science, 616(7958)
In eukaryotes, genomic DNA is extruded into loops by cohesin1. By restraining this process, the DNA-binding protein CCCTC-binding factor (CTCF) generates topologically associating domains (TADs)2,3 that have important roles in gene regulation and rec
Membrane abscission, the final cut of the last connection between emerging daughter cells, is an indispensable event in the last stage of cell division, as well as in other cellular processes such as endocytosis, virus release, or bacterial sporulati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2c8c42175efde1e7403a167282378b27
https://doi.org/10.1101/2022.12.05.519112
https://doi.org/10.1101/2022.12.05.519112
To understand the dynamic nature of the genome in real time, the localization and rearrangement of DNA and DNA-binding proteins must be analyzed across the entire nucleus of single living cells. Recently, we developed a new computational light micros
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::78c9064742f0f9734e8fc219574965f8
https://doi.org/10.1101/2022.11.17.516893
https://doi.org/10.1101/2022.11.17.516893