Zobrazeno 1 - 10 of 15 pro vyhledávání: '"Roman A. Drokin"'
1
Akademický článek
2-Furyl-6-nitro-1,2,4-triazolo [1,5-a]pyrimidin-7-one
Autor: Victor V. Fedotov, Konstantin V. Savateev, Evgeny N. Ulomsky, Roman A. Drokin, Pavel A. Slepukhin, Vladimir L. Rusinov
Publikováno v: Molbank, Vol 2023, Iss 1, p M1563 (2023)
A sodium salt of 2-(fur-2-yl)-6-nitro-1,2,4-triazolo[1,5-a]pyrimidin-7-one as a close structural analogue of ZM-241385 was obtained. This heterocycle can serve as an effector for A2a adenosine receptors and possesses antiseptic activity. The structur
Externí odkaz: https://doaj.org/article/72e14f0911a7475bb4bd41944d02e95b
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2
Akademický článek
The electrochemical behavior’s character of a potential antiviral drug 3-nitro-4-hydroxy-7-methylthio-4H-[1,2,4]triazolo[5,1-c][1,2,4]triazinide monohydrate
Autor: Polina N. Mozharovskaia, Alexandra V. Ivoilova, Roman A. Drokin, Alla V. Ivanova, Alisa N. Kozitsina, Vladimir L. Rusinov
Publikováno v: Chimica Techno Acta, Vol 9, Iss 4 (2022)
The results of this study of the electrochemical transformation of 3-R-4-hydroxy-1,4-dihydro-7-X-1,2,4-triazolo[5,1-c][1,2,4] obtained by voltammetry are presented. It was found that 3-R-4-hydroxy-1,4-dihydro-7-X-1,2,4-triazolo[5,1-c][1,2,4] derivati
Externí odkaz: https://doaj.org/article/4e73452673e845eb9c3fe721a3d91f4c
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3
Methods of Synthesis and Antiviral Activity of New 4-Alkyl-3-Nitro-1,4-Dihydroazolo[5,1-c][1,2,4]Triazin-4-ols
Autor: Roman A. Drokin, Dmitrii V. Tiufiakov, Alexandrina S. Volobueva, Kristina S Lantseva, Egor K. Voinkov, Mariya A Misyurina, Vladimir V. Zarubaev, Evgeny N. Ulomsky, Yana L Esaulkova, Vladimir L. Rusinov, Pavel A. Slepukhin
Publikováno v: Chemistry of Heterocyclic Compounds
Chem. Heterocycl. Compd.
[Figure not available: see fulltext.] An azo coupling reaction of α-nitro ketones with 5-diazoazoles was used to obtain 4-alkyl-3-nitro-1,4-dihydroazolo[5,1-с][1,2,4]triazines, which were characterized with respect to their antiviral activity again
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea26b3c8803573fa671cb9a504e6bcec
http://europepmc.org/articles/PMC8113020
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4
Prediction of Antiglycation Activity by Calculating the Energies of Frontier Molecular Orbitals for New 4-Hydroxy-1,4-Dihydroazolo[5,1-c]-1,2,4-Triazines Used as an Example
Autor: Alexander A. Spasov, Vladimir L. Rusinov, Egor K. Voinkov, D. D. Shamshina, Roman A. Drokin, M. Yu. Kalenova, E. N. Ulomskiy, R. A. Litvinov, L. E. Usmianova, E. A. Muraveva, P. M. Vasiliev
Publikováno v: Russian Journal of Bioorganic Chemistry. 46:1278-1284
Protein glycation and the formation of advanced glycation end products (AGEs) play an important role in the pathogenesis of diabetes mellitus (DM) complications, neurodegenerations, and age-related diseases. A model to predict antiglycation activity
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::68ba3d4a50120b2fed47b65d2966fb96
https://doi.org/10.1134/s1068162020060175
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5
Methods of Synthesis for the Azolo[1,2,4]Triazines
Autor: Roman A. Drokin, Valery N. Charushin, Oleg N. Chupakhin, Egor K. Voinkov, Evgeny N. Ulomsky, Vladimir L. Rusinov
Publikováno v: Chemistry of Heterocyclic Compounds. 56:1254-1273
The review summarizes and analyzes data from modern information sources on the methods of synthesis of azolo[X,Y-c][1,2,4]triazines. Approaches to the construction of the condensed azolotriazine heterocyclic system are considered and classified, the
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4871d880358eaa9abdcfad61830defa5
https://doi.org/10.1007/s10593-020-02808-z
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6
The antioxidant screening of potential materials for drugs based on 6-nitro-1,2,4-triazoloazines containing natural polyphenol fragments
Autor: E. L. Gerasimova, A. V. Ivanova, Roman A. Drokin, Evgeny B. Gorbunov, Vladimir L. Rusinov, E. N. Ulomskiy, E. R. Gazizullina, Marya Borisova
Publikováno v: Analytical and Bioanalytical Chemistry. 412:5147-5155
The course of viral diseases is accompanied by excessive generation of active oxygen metabolites, so the effectiveness of treatment can be improved by combining antiviral and antioxidant therapy. There was a screening of antioxidant properties of 6-n
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::84f2ea977f0ba6e959cb1db956a5b0e1
https://doi.org/10.1007/s00216-020-02466-2
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8
Synthesis and properties of the salts of 1-nitropropan-2-one and 1-nitrobutan-2-one
Autor: Vladimir L. Rusinov, Dmitrii V. Tiufiakov, Egor K. Voinkov, Evgeny N. Ulomsky, Roman A. Drokin
Publikováno v: Mendeleev Communications. 30:177-179
A new safe synthesis of α-nitro ketone salts via alkaline hydrolysis of 2-morpholino-1-nitroalkenes has been developed. The salts were introduced into the reactions of diazotization and heterocyclization. Crystal structures of new 2-morpholino-1-nit
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2250812997fe18d3b70a6e0ec62c1eac
https://doi.org/10.1016/j.mencom.2020.03.015
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10
ANRORC process in 1-alkylazolo[5,1-c][1,2,4]triazin-4(1H)-ones
Autor: Evgeny B. Gorbunov, Oleg N. Chupakhin, Daniil N. Lyapustin, Oleg S. Eltsov, Victor V. Fedotov, Egor K. Voinkov, E. N. Ulomskiy, K. V. Savateev, Roman A. Drokin, Evgeny M. Mukhin, Vladimir L. Rusinov
Publikováno v: Chemistry of Heterocyclic Compounds. 54:63-69
Nucleophilic substitution of nitro group in 1-alkylazolo[5,1-c][1,2,4]triazin-4(1H)-ones proceeds according to the ANRORC mechanism, involving the opening of azine ring, nucleophilic substitution, and cyclization. The structures of all intermediates
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a7ca2720d7e3d4b90bcd46ad77ae8ff6
https://doi.org/10.1007/s10593-018-2231-0
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