Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Roman Šášik"'
Autor:
Kathleen M. Fisch, Sara Brin Rosenthal, Adam Mark, Roman Sasik, Chanond A. Nasamran, Royce Clifford, M. Jennifer Derebery, Ely Boussaty, Kristen Jepsen, Jeffrey Harris, Rick A. Friedman
Publikováno v:
BMC Genomics, Vol 25, Iss 1, Pp 1-12 (2024)
Abstract Background Ménière's disease (MD) is a disorder of the inner ear that causes episodic bouts of severe dizziness, roaring tinnitus, and fluctuating hearing loss. To date, no targeted therapy exists. As such, we have undertaken a large whole
Externí odkaz:
https://doaj.org/article/8da97123b0944854b490b79a85cae0b7
Autor:
Maria Rivera, Haoran Zhang, Jessica Pham, Jane Isquith, Qingchen Jenny Zhou, Larisa Balaian, Roman Sasik, Sabina Enlund, Adam Mark, Wenxue Ma, Frida Holm, Kathleen M. Fisch, Dennis John Kuo, Catriona Jamieson, Qingfei Jiang
Publikováno v:
Cell Reports, Vol 43, Iss 2, Pp 113704- (2024)
Summary: Leukemia-initiating cells (LICs) are regarded as the origin of leukemia relapse and therapeutic resistance. Identifying direct stemness determinants that fuel LIC self-renewal is critical for developing targeted approaches. Here, we show tha
Externí odkaz:
https://doaj.org/article/c38817c1a9874ab3beb3e61fc1147ab9
Autor:
Asha Kumari, Raul Ayala-Ramirez, Juan Carlos Zenteno, Kristyn Huffman, Roman Sasik, Radha Ayyagari, Shyamanga Borooah
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-20 (2022)
Abstract Mutations in the Membrane-type frizzled related protein (Mfrp) gene results in an early-onset retinal degeneration associated with retinitis pigmentosa, microphthalmia, optic disc drusen and foveal schisis. In the current study, a previously
Externí odkaz:
https://doaj.org/article/0afd4618ed6543c89f68e663ea00ae78
Autor:
Rizaldy C. Zapata, Maria Carretero, Felipe Castellani Gomes Reis, Besma S. Chaudry, Jachelle Ofrecio, Dinghong Zhang, Roman Sasik, Theodore Ciaraldi, Michael Petrascheck, Olivia Osborn
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
Energy metabolism is dysregulated in obesity, and some if these changes persist after weight loss and may contribute to weight regain. Here the authors report that a vacuolar-type H+ ATPase, ATP6v0a1, is induced in adipocytes during obesity and persi
Externí odkaz:
https://doaj.org/article/9c2f22f3559c458592f04adcdf76285c
Autor:
Melissa K. Jones, Devansh Agarwal, Kevin W. Mazo, Manan Chopra, Shawna L. Jurlina, Nicholas Dash, Qianlan Xu, Anna R. Ogata, Melissa Chow, Alex D. Hill, Netra K. Kambli, Guorong Xu, Roman Sasik, Amanda Birmingham, Kathleen M. Fisch, Robert N. Weinreb, Ray A. Enke, Dorota Skowronska-Krawczyk, Karl J. Wahlin
Publikováno v:
Cells, Vol 11, Iss 21, p 3412 (2022)
Retinogenesis involves the specification of retinal cell types during early vertebrate development. While model organisms have been critical for determining the role of dynamic chromatin and cell-type specific transcriptional networks during this pro
Externí odkaz:
https://doaj.org/article/568705fe409a446e876d06d49571acbe
Autor:
Akihiro Sakai, Mizuo Ando, Takahito Fukusumi, Shuling Ren, Chao Liu, Jesse Qualliotine, Sunny Haft, Sayed Sadat, Yuki Saito, Theresa W Guo, Guorong Xu, Roman Sasik, Kathleen M Fisch, J Silvio Gutkind, Elana J Fertig, Alfredo A Molinolo, Joseph A Califano
Publikováno v:
PLoS ONE, Vol 15, Iss 5, p e0233380 (2020)
Alternative mRNA splicing increases protein diversity, and alternative splicing events (ASEs) drive oncogenesis in multiple tumor types. However, the driving alterations that underlie the broad dysregulation of ASEs are incompletely defined. Using he
Externí odkaz:
https://doaj.org/article/f4066e559bd14055b02f0f7dceea5315
Autor:
Manoj K. Kashyap, Deepak Kumar, Reymundo Villa, James J. La Clair, Chris Benner, Roman Sasik, Harrison Jones, Emanuela M. Ghia, Laura Z. Rassenti, Thomas J. Kipps, Michael D. Burkart, Januario E. Castro
Publikováno v:
Haematologica, Vol 100, Iss 7 (2015)
RNA splicing plays a fundamental role in human biology. Its relevance in cancer is rapidly emerging as demonstrated by spliceosome mutations that determine the prognosis of patients with hematologic malignancies. We report studies using FD-895 and pl
Externí odkaz:
https://doaj.org/article/d2cf4769f51e47a1a7c8713f79b75b8c
Autor:
Rachel A Patterson, Michelle T Juarez, Anita Hermann, Roman Sasik, Gary Hardiman, William McGinnis
Publikováno v:
PLoS ONE, Vol 8, Iss 4, p e61773 (2013)
After injury to the animal epidermis, a variety of genes are transcriptionally activated in nearby cells to regenerate the missing cells and facilitate barrier repair. The range and types of diffusible wound signals that are produced by damaged epide
Externí odkaz:
https://doaj.org/article/125b5599006d415d843bb8952b29a4a3
Autor:
Laure Escoubet-Lozach, Christopher Benner, Minna U Kaikkonen, Jean Lozach, Sven Heinz, Nathan J Spann, Andrea Crotti, Josh Stender, Serena Ghisletti, Donna Reichart, Christine S Cheng, Rosa Luna, Colleen Ludka, Roman Sasik, Ivan Garcia-Bassets, Alexander Hoffmann, Shankar Subramaniam, Gary Hardiman, Michael G Rosenfeld, Christopher K Glass
Publikováno v:
PLoS Genetics, Vol 7, Iss 12, p e1002401 (2011)
Precise control of the innate immune response is required for resistance to microbial infections and maintenance of normal tissue homeostasis. Because this response involves coordinate regulation of hundreds of genes, it provides a powerful biologica
Externí odkaz:
https://doaj.org/article/f69a8d7af71742de8be55e14a6e909d9
Autor:
Michael E Baker, Doris E Vidal-Dorsch, Cataldo Ribecco, L James Sprague, Mila Angert, Narimene Lekmine, Colleen Ludka, Andrea Martella, Eugenia Ricciardelli, Steven M Bay, Joseph R Gully, Kevin M Kelley, Daniel Schlenk, Oliana Carnevali, Roman Šášik, Gary Hardiman
Publikováno v:
PLoS ONE, Vol 8, Iss 9, p e75553 (2013)
Sentinel fish hornyhead turbot (Pleuronichthysverticalis) captured near wastewater outfalls are used for monitoring exposure to industrial and agricultural chemicals of ~ 20 million people living in coastal Southern California. Although analyses of h
Externí odkaz:
https://doaj.org/article/d7f4cc2f1de044878a990396e4372f00