Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Roman, Nikolaienko"'
Publikováno v:
Biophysical Reports, Vol 4, Iss 4, Pp 100183- (2024)
The type 2 ryanodine receptor (RyR2) is the major Ca2+ release channel required for Ca2+-induced Ca2+ release (CICR) and cardiac excitation-contraction coupling. The cluster organization of RyR2 at the dyad is critical for efficient CICR. Despite its
Externí odkaz:
https://doaj.org/article/54929fb3d52749999e9d561e5452305c
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-11 (2023)
Abstract The most common cardiac pathologies, such as myocardial infarction and heart failure, are associated with oxidative stress. Oxidation of the cardiac ryanodine receptor (RyR2) Ca2+ channel causes spontaneous oscillations of intracellular Ca2+
Externí odkaz:
https://doaj.org/article/2742a05fc3314e5fa21ea18ac8e36dfb
Autor:
Roman Nikolaienko, Elisa Bovo, Samantha L. Yuen, Levy M. Treinen, Kaja Berg, Courtney C. Aldrich, David D. Thomas, Razvan L. Cornea, Aleksey V. Zima
Publikováno v:
Biophysical Journal. 122:386-396
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7f08299046a0f8c929aa4af04244b32d
https://doi.org/10.1016/j.bpj.2022.12.002
https://doi.org/10.1016/j.bpj.2022.12.002
Autor:
Roman Nikolaienko, Elisa Bovo, Robyn T. Rebbeck, Daniel Kahn, David D. Thomas, Razvan L. Cornea, Aleksey V. Zima
Publikováno v:
Redox Biology, Vol 37, Iss , Pp 101729- (2020)
The type 2 ryanodine receptor (RyR2) plays a key role in the cardiac intracellular calcium (Ca2+) regulation. We have previously shown that oxidative stress activates RyR2 in rabbit cardiomyocytes by promoting the formation of disulfide bonds between
Externí odkaz:
https://doaj.org/article/87b66c161906474facd24ffdd8891d89
Publikováno v:
Frontiers in Physiology, Vol 9 (2018)
Heart contraction vitally depends on tightly controlled intracellular Ca regulation. Because contraction is mainly driven by Ca released from the sarcoplasmic reticulum (SR), this organelle plays a particularly important role in Ca regulation. The ty
Externí odkaz:
https://doaj.org/article/0e0b5a47e8ff44d897cf8f277f19ff1d
Autor:
Roman, Nikolaienko, Elisa, Bovo, Samantha L, Yuen, Levy M, Treinen, Kaja, Berg, Courtney C, Aldrich, David D, Thomas, Razvan L, Cornea, Aleksey V, Zima
Publikováno v:
Biophysical journal.
The type 2a sarco/endoplasmic reticulum Ca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::29cd0c5d17cd6395bc5c6677ffd59295
https://pubmed.ncbi.nlm.nih.gov/36463408
https://pubmed.ncbi.nlm.nih.gov/36463408
Autor:
Sean R. Cleary, Jaroslava Seflova, Aleksey V. Zima, Daniel Kahn, Roman Nikolaienko, Seth L. Robia, Elisa Bovo
Publikováno v:
Biophys J
The type 2a sarco/endoplasmic reticulum (ER) Ca(2+)-ATPase (SERCA2a) plays a key role in intracellular Ca(2+) regulation in the heart. We have previously shown evidence of stable homodimers of SERCA2a in heterologous cells and cardiomyocytes. However
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b218d7cdf781380e64a3026c80b41f7
https://doi.org/10.1016/j.bpj.2020.08.025
https://doi.org/10.1016/j.bpj.2020.08.025
Autor:
Razvan L. Cornea, Ching-Chieh Tung, Daniel P. Singh, Filip Van Petegem, Donald M. Bers, Bengt Svensson, Kaja Rožman, Levy M. Treinen, Siobhan M. Wong King Yuen, Courtney C. Aldrich, Bradley S. Launikonis, Jingyan Zhang, David D. Thomas, Aleksey V. Zima, Jacob A. Schwarz, Christopher Y. Ko, Roman Nikolaienko
Publikováno v:
The Journal of biological chemistry, vol 298, iss 1
The Journal of Biological Chemistry
The Journal of Biological Chemistry
The N-terminal region (NTR) of ryanodine receptor (RyR) channels is critical for the regulation of Ca2+ release during excitation–contraction (EC) coupling in muscle. The NTR hosts numerous mutations linked to skeletal (RyR1) and cardiac (RyR2) myo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62e651b16da8560235f301c406f3eb42
https://escholarship.org/uc/item/1sw1d750
https://escholarship.org/uc/item/1sw1d750
Autor:
Elisa Bovo, Roman Nikolaienko, Daniel Kahn, Jody L. Martin, John Q. Yap, Seth L. Robia, Aleksey V. Zima
Publikováno v:
Biophysical Journal. 122:528a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a89a0de4d72d6afdfd76679ac63ebee0
https://doi.org/10.1016/j.bpj.2022.11.2801
https://doi.org/10.1016/j.bpj.2022.11.2801
Autor:
Jody L. Martin, Quan Cao, Seth L. Robia, Elisa Bovo, Roman Nikolaienko, Siddharth Bhayani, Aleksey V. Zima, Ivana Y. Kuo, Daniel Kahn
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology. 316:H1323-H1331
The type 2a sarco-/endoplasmic reticulum Ca2+-ATPase (SERCA2a) plays a key role in Ca2+regulation in the heart. However, available techniques to study SERCA function are either cell destructive or lack sensitivity. The goal of this study was to devel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9485fb6c4d3ff3c217ae146c3eb6b823
https://doi.org/10.1152/ajpheart.00031.2019
https://doi.org/10.1152/ajpheart.00031.2019