Zobrazeno 1 - 10
of 134
pro vyhledávání: '"Roman, Krawetz"'
Autor:
Breanna S. Borys, Tiffany Dang, Hannah Worden, Leila Larijani, Jessica M. Corpuz, Brett D. Abraham, Emilie J. Gysel, Julia Malinovska, Roman Krawetz, Tamas Revay, Bob Argiropoulos, Derrick E. Rancourt, Michael S. Kallos, Sunghoon Jung
Publikováno v:
Stem Cell Research & Therapy, Vol 15, Iss 1, Pp 1-19 (2024)
Abstract Background While pluripotent stem cell (PSC) therapies move toward clinical and commercial applications at a rapid rate, manufacturing reproducibility and robustness are notable bottlenecks in regulatory approval. Therapeutic applications of
Externí odkaz:
https://doaj.org/article/2db8d01dfcf348088a43dc9d70f85a86
Autor:
Nabangshu Das, Luiz G. N. de Almeida, Afshin Derakhshani, Daniel Young, Kobra Mehdinejadiani, Paul Salo, Alexander Rezansoff, Gregory D. Jay, Christian P. Sommerhoff, Tannin A. Schmidt, Roman Krawetz, Antoine Dufour
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-20 (2023)
Altered expression and function of the extracellular matrix protein PRG4 have been associated with osteoarthritis. Here, the authors show that mast cell tryptase β cleaves PRG4, resulting in a reduction of lubrication and activation of inflammation
Externí odkaz:
https://doaj.org/article/acd1e0dd071f4882af74316106133957
Autor:
Shan Huang, Kristina A. Thomsson, Chunsheng Jin, Henrik Ryberg, Nabangshu Das, André Struglics, Ola Rolfson, Lena I. Björkman, Thomas Eisler, Tannin A. Schmidt, Gregory D. Jay, Roman Krawetz, Niclas G. Karlsson
Publikováno v:
Frontiers in Molecular Biosciences, Vol 9 (2022)
The primary aim of the study was to identify inflammatory markers relevant for osteoarthritis (OA)-related systemic (plasma) and local (synovial fluid, SF) inflammation. From this, we looked for inflammatory markers that coincided with the increased
Externí odkaz:
https://doaj.org/article/6b701682bbad4a48b68b04253d62c085
Autor:
Breanna S. Borys, Tania So, James Colter, Tiffany Dang, Erin L. Roberts, Tamas Revay, Leila Larijani, Roman Krawetz, Ian Lewis, Bob Argiropoulos, Derrick E. Rancourt, Sunghoon Jung, Yas Hashimura, Brian Lee, Michael S. Kallos
Publikováno v:
Stem Cells Translational Medicine, Vol 9, Iss 9, Pp 1036-1052 (2020)
Abstract Human induced pluripotent stem cells (hiPSCs) have generated a great deal of attention owing to their capacity for self‐renewal and differentiation into the three germ layers of the body. Their discovery has facilitated a new era in biomed
Externí odkaz:
https://doaj.org/article/12cda13c70c14445b8dbe352327b75a7
Autor:
Nabangshu Das, Nikhil G. Menon, Luiz G. N. de Almeida, Paige S. Woods, Miriam L. Heynen, Gregory D. Jay, Barbara Caffery, Lyndon Jones, Roman Krawetz, Tannin A. Schmidt, Antoine Dufour
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2021)
Sjogren’s syndrome (SS) is characterized by dysfunctional mucous membranes and dysregulated moisture-secreting glands resulting in various symptoms, including dry mouth and dry eyes. Here, we wanted to profile and compare the tear and saliva proteo
Externí odkaz:
https://doaj.org/article/ea610b274d034bbd8e65ca465bd64bfd
Autor:
Marta Marchini, Mitchell R. Ashkin, Melina Bellini, Margaret Man-Ger Sun, Matthew Lloyd Workentine, Hamza Malik Okuyan, Roman Krawetz, Frank Beier, Campbell Rolian
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
The genetic and developmental mechanisms involved in limb formation are relatively well documented, but how these mechanisms are modulated by changes in chondrocyte physiology to produce differences in limb bone length remains unclear. Here, we used
Externí odkaz:
https://doaj.org/article/05ab1663cf714492bcab056f6ad6f605
Autor:
Lijie Gao, Suman C. Nath, Xiyao Jiao, Rongyan Zhou, Sandra Nishikawa, Roman Krawetz, Xiangyun Li, Derrick E. Rancourt
Publikováno v:
Stem Cell Research, Vol 41, Iss , Pp - (2019)
Human embryonic stem cells (hESCs) and induced pluripotent stem cells (hiPSCs) are prone to anoikis after single cell dissociation. The small molecule, Y-27632 is known to increase survival of hESCs and hiPSCs by inhibiting the Rho-associated protein
Externí odkaz:
https://doaj.org/article/88b1631065ac4bb5956c9bb3e8d7704d
Autor:
Priyatha Premnath, Britta Jorgenson, Ricarda Hess, Pankaj Tailor, Dante Louie, Jaymi Taiani, Steven Boyd, Roman Krawetz
Publikováno v:
BMC Musculoskeletal Disorders, Vol 18, Iss 1, Pp 1-10 (2017)
Abstract Background p21(WAF1/CIP1/SDI1), a cyclin dependent kinase inhibitor has been shown to influence cell proliferation, differentiation and apoptosis; but more recently, p21 has been implicated in tissue repair. Studies on p21(−/−) knockout
Externí odkaz:
https://doaj.org/article/2bce679d2ba0490ba3a16acbc05357da
Publikováno v:
PLoS ONE, Vol 14, Iss 4, p e0215018 (2019)
p21(WAF1/CIP1/SDI1) is a critical sentinel of the cell cycle that plays an important role in determining cell fate with respect to proliferation, differentiation and apoptosis. Recent studies have demonstrated that inhibition/loss of p21 promotes ost
Externí odkaz:
https://doaj.org/article/1c3506f92cda48dfa16d7ce7f08dff6c
Publikováno v:
Stem Cells International, Vol 2019 (2019)
Study Design. Isolation and characterization of human epidural fat (HEF) stem/progenitor cells. Objective. To identify a progenitor population within HEF and to determine if they meet the minimal criteria of a mesenchymal stem cell (MSC). Summary of
Externí odkaz:
https://doaj.org/article/82b2fac9603d49fdb7f194b8a4dc586e