Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Roman, Istomine"'
Autor:
Roman Istomine, Tho-Alfakar Al-Aubodah, Fernando Alvarez, Jacob A. Smith, Carston Wagner, Ciriaco A. Piccirillo
Publikováno v:
iScience, Vol 26, Iss 5, Pp 106683- (2023)
Summary: CD4+ T cells are critical for adaptive immunity, differentiating into distinct effector and regulatory subsets. Although the transcriptional programs underlying their differentiation are known, recent research has highlighted the importance
Externí odkaz:
https://doaj.org/article/79ad2a0d63d34a2eb007a61e7e6caa48
Autor:
Simon Milette, Masakazu Hashimoto, Stephanie Perrino, Shu Qi, Michely Chen, Boram Ham, Ni Wang, Roman Istomine, Andrew M. Lowy, Ciriaco A. Piccirillo, Pnina Brodt
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
It is known that estrogens can affect the immune response to cancer. Here, the authors show that estrogen depletion through ovariectomy reduces the extent of liver metastasis and that this is accompanied by a decrease in the number and function of im
Externí odkaz:
https://doaj.org/article/03601799ff694067bb6f3ab7d58e813f
Autor:
Yujian H. Yang, Roman Istomine, Fernando Alvarez, Tho-Alfakar Al-Aubodah, Xiang Qun Shi, Tomoko Takano, Angela M. Thornton, Ethan M. Shevach, Ji Zhang, Ciriaco A. Piccirillo
Publikováno v:
Cell Reports, Vol 30, Iss 5, Pp 1515-1529.e4 (2020)
Summary: Regulatory T (Treg) cells integrate diverse environmental signals to modulate their function for optimal suppression. Translational regulation represents a favorable mechanism for Treg cell environmental sensing and adaptation. In this study
Externí odkaz:
https://doaj.org/article/8b33c085871f449f89fb91c11d935cc7
Publikováno v:
Autoimmunity, Vol 50, Iss 6, Pp 354-362 (2017)
A progressive waning in Foxp3+ regulatory T (Treg) cell function provokes autoimmunity in the non-obese diabetic (NOD) mouse model of type 1 diabetes (T1D), a cellular defect rescued by prophylactic IL-2 therapy. We showed that most islet-infiltratin
Externí odkaz:
https://doaj.org/article/0f0dc32aed2f4eae96b8efca226cdcaa
Autor:
Jinsam Chang, Antoine Bouchard, Yasser Bouklouch, Vincent Panneton, Joanna Li, Nikoletta Diamantopoulos, Saba Mohammaei, Roman Istomine, Fernando Alvarez, Ciriaco A. Piccirillo, Woong-Kyung Suh
Publikováno v:
The Journal of Immunology. 209:301-309
ICOS is induced in activated T cells and its main role is to boost differentiation and function of effector T cells. ICOS is also constitutively expressed in a subpopulation of Foxp3+ regulatory T cells under steady-state condition. Studies using ICO
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d085b1f59cd7427c619f8c9f0bebb846
https://doi.org/10.4049/jimmunol.2100897
https://doi.org/10.4049/jimmunol.2100897
Autor:
Fernando Alvarez, Roman Istomine, Hilary Hendin, Breanna Hodgins, Stephane Pillet, Jörg H. Fritz, Nathalie Charland, Brian J. Ward, Ciriaco A. Piccirillo
Publikováno v:
ImmunoHorizons. 6:384-397
Inactivated influenza vaccines have struggled to provide consistent protection in older individuals. Circumventing immune senescence, an aging of the immune response characterized by weak humoral responses to vaccines, and unchecked inflammation duri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1dec251507a1d2cf669329028f03043
https://doi.org/10.4049/immunohorizons.2200036
https://doi.org/10.4049/immunohorizons.2200036
Autor:
M. Florencia Iulita, Sonia Duchemin, Diane Vallerand, Tlili Barhoumi, Fernando Alvarez, Roman Istomine, Cyril Laurent, Jessica Youwakim, Pierre Paradis, Nathalie Arbour, Ciriaco A. Piccirillo, Ernesto L. Schiffrin, Hélène Girouard
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 8, Iss 1 (2019)
Background Immune cells are key regulators of the vascular inflammatory response characteristic of hypertension. In hypertensive rodents, regulatory T lymphocytes (Treg, CD4+CD25+) prevented vascular injury, cardiac damage, and endothelial dysfunctio
Externí odkaz:
https://doaj.org/article/7491ecb9dfeb40cabf315a1958cae5e8
Autor:
Fernando Alvarez, Roman Istomine, Alonso Da Silva Lira Filho, Tho-Alfakar Al-Aubodah, Daniel Huang, Rakan Okde, Martin Olivier, Jörg H. Fritz, Ciriaco A. Piccirillo
Publikováno v:
Mucosal Immunology.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d840927bc22950e45b95b9b11066b9e7
https://doi.org/10.1016/j.mucimm.2023.05.004
https://doi.org/10.1016/j.mucimm.2023.05.004
Autor:
Hui-Qi Qu, Hakon Hakonarson, Luc Marchand, Despoina Manousaki, Roman Istomine, Andrew D. Paterson, Min Li, Constantin Polychronakos, Dcct, Vincenzo Forgetta, Marie-Catherine Tessier, Ciriaco A. Piccirillo, Struan F.A. Grant, Stephanie Ross, J. Brent Richards, Jonathan P. Bradfield
Publikováno v:
Diabetes
Most replicated genetic determinants for type 1 diabetes are common (minor allele frequency [MAF] >5%). We aimed to identify novel rare or low-frequency (MAF
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::883465cb584ce9e831919dcdedcf54e4
http://europepmc.org/articles/PMC7085253
http://europepmc.org/articles/PMC7085253
Autor:
Masakazu Hashimoto, Roman Istomine, Stephanie Perrino, Andrew M. Lowy, Pnina Brodt, Michely Chen, Ciriaco A. Piccirillo, Shu Qi, Boram Ham, Simon Milette, Ni Wang
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
Nature Communications
Nature Communications
Liver metastases (LM) remain a major cause of cancer-associated death and a clinical challenge. Here we explore a sexual dimorphism observed in the regulation of the tumor immune microenvironment (TIME) of LM, wherein the accumulation of myeloid-deri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be33fb7d1d6cf2ebd952acbbe9edda7d
https://doaj.org/article/03601799ff694067bb6f3ab7d58e813f
https://doaj.org/article/03601799ff694067bb6f3ab7d58e813f