Zobrazeno 1 - 10
of 298
pro vyhledávání: '"Roman, Fischer"'
Publikováno v:
Signal Transduction and Targeted Therapy, Vol 9, Iss 1, Pp 1-3 (2024)
Externí odkaz:
https://doaj.org/article/54ac0590f760449fa5d58ca561434344
Autor:
Chao-Hui Chang, Feng Liu, Stefania Militi, Svenja Hester, Reshma Nibhani, Siwei Deng, James Dunford, Aniko Rendek, Zahir Soonawalla, Roman Fischer, Udo Oppermann, Siim Pauklin
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-29 (2024)
Abstract The lethality, chemoresistance and metastatic characteristics of cancers are associated with phenotypically plastic cancer stem cells (CSCs). How the non-cell autonomous signalling pathways and cell-autonomous transcriptional machinery orche
Externí odkaz:
https://doaj.org/article/2125cb9f886147e3b057aef73e84507f
Autor:
Lars Palmowski, Maike Weber, Malte Bayer, Yuxin Mi, Karin Schork, Martin Eisenacher, Hartmuth Nowak, Tim Rahmel, Lars Bergmann, Andrea Witowski, Björn Koos, Katharina Rump, Dominik Ziehe, Ulrich Limper, Dietrich Henzler, Stefan Felix Ehrentraut, Alexander Zarbock, Roman Fischer, Julian C. Knight, Michael Adamzik, Barbara Sitek, Thilo Bracht
Publikováno v:
EBioMedicine, Vol 111, Iss , Pp 105508- (2025)
Summary: Background: Sepsis remains a leading cause of mortality in intensive care units. Understanding the dynamics of the plasma proteome of patients with sepsis is critical for improving prognostic and therapeutic strategies. Methods: This prospec
Externí odkaz:
https://doaj.org/article/31568610c3594f568b823ac69e27a4a8
Autor:
Thamali Ayagama, Philip D. Charles, Samuel J. Bose, Barry Boland, David A. Priestman, Daniel Aston, Georgina Berridge, Roman Fischer, Adam P. Cribbs, Qianqian Song, Gary R. Mirams, Kwabena Amponsah, Lisa Heather, Antony Galione, Neil Herring, Holger Kramer, Rebecca A. Capel, Frances M. Platt, Ulrich Schotten, Sander Verheule, Rebecca A.B. Burton
Publikováno v:
iScience, Vol 27, Iss 6, Pp 109609- (2024)
Summary: Endolysosomes (EL) are known for their role in regulating both intracellular trafficking and proteostasis. EL facilitate the elimination of damaged membranes, protein aggregates, membranous organelles and play an important role in calcium si
Externí odkaz:
https://doaj.org/article/5ce7e4802b624eb9b2d4d4afc4a88738
Autor:
Simon Davis, Connor Scott, Janina Oetjen, Philip D. Charles, Benedikt M. Kessler, Olaf Ansorge, Roman Fischer
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)
Abstract The spatial organisation of cellular protein expression profiles within tissue determines cellular function and is key to understanding disease pathology. To define molecular phenotypes in the spatial context of tissue, there is a need for u
Externí odkaz:
https://doaj.org/article/a9c62d9e72e54c4baedf487a7e9f1c8a
Autor:
Kayla L. Nguyen, Ishaan J. Bhatt, Shruti Gupta, Nazaf Showkat, Kathryn A. Swanson, Roman Fischer, Roland E. Kontermann, Klaus Pfizenmaier, Valerie Bracchi-Ricard, John R. Bethea
Publikováno v:
Brain Research Bulletin, Vol 207, Iss , Pp 110885- (2024)
Multiple sclerosis (MS), a demyelinating autoimmune disease of the central nervous system (CNS), predominately affects females compared to males. Tumor necrosis factor (TNF), a pro-inflammatory cytokine, signaling through TNF receptor 1 contributes t
Externí odkaz:
https://doaj.org/article/667057d00d2a42bdb40ed215236bb75d
Autor:
Dedrick Kok Hong Chan, Amit Mandal, Svenja Hester, Zhanru Yu, Geoff Stuart Higgins, Benedikt Mathias Kessler, Roman Fischer, Simon James Alexander Buczacki
Publikováno v:
Cell Death Discovery, Vol 9, Iss 1, Pp 1-15 (2023)
Abstract Colorectal cancer possesses marked intratumoral heterogeneity. While subclonal interactions between Vogelstein driver mutations have been extensively studied, less is known about competitive or cooperative effects between subclonal populatio
Externí odkaz:
https://doaj.org/article/65b8402923f940d589405975c7c13b1c
Autor:
Natalia Ortí-Casañ, Ate S. Boerema, Karina Köpke, Amber Ebskamp, Jan Keijser, Yuequ Zhang, Tingting Chen, Amalia M. Dolga, Kerensa Broersen, Roman Fischer, Klaus Pfizenmaier, Roland E. Kontermann, Ulrich L. M. Eisel
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-13 (2023)
Abstract Tumor necrosis factor alpha (TNF-α) and its key role in modulating immune responses has been widely recognized as a therapeutic target for inflammatory and neurodegenerative diseases. Even though inhibition of TNF-α is beneficial for the t
Externí odkaz:
https://doaj.org/article/c98638b7b125423496722b05327a5864
Autor:
Valentina Pegoretti, Jan Bauer, Roman Fischer, Iskra Paro, Wanda Douwenga, Roland E. Kontermann, Klaus Pfizenmaier, Evelien Houben, Bieke Broux, Niels Hellings, Wia Baron, Jon D. Laman, Ulrich L. M. Eisel
Publikováno v:
Journal of Neuroinflammation, Vol 20, Iss 1, Pp 1-13 (2023)
Abstract TNF signaling is an essential regulator of cellular homeostasis. Through its two receptors TNFR1 and TNFR2, soluble versus membrane-bound TNF enable cell death or survival in a variety of cell types. TNF-TNFRs signaling orchestrates importan
Externí odkaz:
https://doaj.org/article/5841bf7052c54683ab34c56469546a89
Autor:
Timon Fiedler, Richard Fairless, Kira Pichi, Roman Fischer, Fabian Richter, Roland E. Kontermann, Klaus Pfizenmaier, Ricarda Diem, Sarah K. Williams
Publikováno v:
Journal of Neuroinflammation, Vol 20, Iss 1, Pp 1-13 (2023)
Abstract Background Tumour necrosis factor (TNF) is a pleiotropic cytokine and master regulator of the immune system. It acts through two receptors resulting in often opposing biological effects, which may explain the lack of therapeutic potential ob
Externí odkaz:
https://doaj.org/article/419220a7d4354d2c8e22cb1683c5790a