Comparison of analytical performances between clot waveform analysis and FibWave in edoxaban‐treated patients and healthy controls

Autor: Jonathan Evrard, Romain Siriez, Céline Bouvy, Julien Favresse, Halil Yildiz, Philippe Hainaut, François Mullier, Jean‐Michel Dogné, Jonathan Douxfils

Publikováno v: Research and Practice in Thrombosis and Haemostasis, Vol 6, Iss 7, Pp n/a-n/a (2022)

Abstract Introduction The activated partial thromboplastin time (aPTT) and the prothrombin time (PT) are widely available coagulation parameters which are however poor predictors of the anticoagulant effect of direct oral anticoagulants (DOACs). Some

Externí odkaz: https://doaj.org/article/9d121dd28dea4655bd8d0228fc63adb6

Performance of a Qualitative Point-of-Care Strip Test to Detect DOAC Exposure at the Emergency Department:A Cohort-Type Cross-Sectional Diagnostic Accuracy Study

Autor: Anne E. Merrelaar, Magdalena S. Bögl, Nina Buchtele, Marieke Merrelaar, Harald Herkner, Christian Schoergenhofer, Job Harenberg, Jonathan Douxfils, Romain Siriez, Bernd Jilma, Alexander O. Spiel, Michael Schwameis

Publikováno v: Merrelaar, A E, Bögl, M S, Buchtele, N, Merrelaar, M, Herkner, H, Schoergenhofer, C, Harenberg, J, Douxfils, J, Siriez, R, Jilma, B, Spiel, A O & Schwameis, M 2022, ' Performance of a Qualitative Point-of-Care Strip Test to Detect DOAC Exposure at the Emergency Department : A Cohort-Type Cross-Sectional Diagnostic Accuracy Study ', Thrombosis and Haemostasis, vol. 122, no. 10, pp. 1723-1731 . https://doi.org/10.1055/s-0042-1750327

An accurate point-of-care test for detecting effective anticoagulation by direct oral anticoagulants (DOACs) in emergencies is an unmet need. We investigated the accuracy of a urinary qualitative strip test (DOAC Dipstick) to detect relevant DOAC exp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d535dea9d6bc3f6ea46c728608d031a5
https://pure.unamur.be/ws/files/64447678/11655_2022_Merrelaar.pdf

Assessment of low plasma concentrations of apixaban in the periprocedural setting

Autor: Anne-Sophie Dincq, Michael Hardy, Lionel Pochet, Anne-Laure Sennesael, Ovidiu Ionut Vornicu, Olivier Deceuninck, Romain Siriez, Sarah Lessire, Jonathan Douxfils, François Mullier

Publikováno v: International journal of laboratory hematology, Vol. 42, no. 4, p. 394-402 (2020)

Introduction: Estimation of residual apixaban plasma concentrations may be requested in the management of emergencies. This study aims at assessing the performance of specific anti-Xa assays calibrated with apixaban on real-life samples with low apix

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::263ca1804ead8895e0235277f17259ad
https://doi.org/10.1111/ijlh.13202

Comprehensive review of the impact of direct oral anticoagulants on thrombophilia diagnostic tests: Practical recommendations for the laboratory

Autor: Julie Laloy, Romain Siriez, Robert C. Gosselin, Jonathan Douxfils, Jean-Michel Dogné, François Mullier

Publikováno v: International journal of laboratory hematology, Vol. 43, no. 1, p. 7-20 (2021)

There is a laboratory and clinical need to know the impact of direct oral anticoagulants (DOACs) on diagnostic tests to avoid misinterpretation of results. Although the regulatory labelling documents provide some information about the influences of e

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac68c377bbc0d8f26696817f1fd95a66
https://hdl.handle.net/2078.1/236009

Importance of measuring pharmacologically active metabolites of edoxaban:development and validation of an ultra-high-performance liquid chromatography coupled with a tandem mass spectrometry method

Autor: Philippe Devel, Lütfiye Alpan, Romain Siriez, Jean-Michel Dogné, Kossay Elasaad, Julie Laloy, Jonathan Douxfils

Publikováno v: Siriez, R, Alpan, L, Elasaad, K, Devel, P, Laloy, J, Dogne, J-M & Douxfils, J 2020, ' Importance of measuring pharmacologically active metabolites of edoxaban : development and validation of an ultra-high-performance liquid chromatography coupled with a tandem mass spectrometry method ', Journal of Thrombosis and Thrombolysis, vol. 49, no. 3, pp. 395-403 . https://doi.org/10.1007/s11239-019-02030-5

Although DOACs do not require regular measurements of their blood concentrations, clinical situations may require an assessment of their concentration. Among the factor Xa inhibitors, edoxaban is the only compound for which some metabolites (e.g. edo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dead061928fc6f2031a201f6fe3b3dbf
https://pure.unamur.be/ws/files/41509105/Edoxaban_measurement_241219.pdf