Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Romain Sigaud"'
Autor:
Romain Sigaud, Thomas K. Albert, Caroline Hess, Thomas Hielscher, Nadine Winkler, Daniela Kocher, Carolin Walter, Daniel Münter, Florian Selt, Diren Usta, Jonas Ecker, Angela Brentrup, Martin Hasselblatt, Christian Thomas, Julian Varghese, David Capper, Ulrich W. Thomale, Pablo Hernáiz Driever, Michèle Simon, Svea Horn, Nina Annika Herz, Arend Koch, Felix Sahm, Stefan Hamelmann, Augusto Faria-Andrade, Nada Jabado, Martin U. Schuhmann, Antoinette Y. N. Schouten-van Meeteren, Eelco Hoving, Tilman Brummer, Cornelis M. van Tilburg, Stefan M. Pfister, Olaf Witt, David T. W. Jones, Kornelius Kerl, Till Milde
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-21 (2023)
Abstract Pediatric low-grade gliomas (pLGG) show heterogeneous responses to MAPK inhibitors (MAPKi) in clinical trials. Thus, more complex stratification biomarkers are needed to identify patients likely to benefit from MAPKi therapy. Here, we identi
Externí odkaz:
https://doaj.org/article/87e41da8f9f6492d937e992bb05c9817
Autor:
Romain Sigaud, Nadège Dussault, Caroline Berenguer-Daizé, Christine Vellutini, Zohra Benyahia, Mylène Cayol, Fabrice Parat, Kamel Mabrouk, Ramiro Vázquez, Maria E. Riveiro, Philippe Metellus, L’Houcine Ouafik
Publikováno v:
Frontiers in Oncology, Vol 11 (2021)
VE-cadherin is an essential adhesion molecule in endothelial adherens junctions, and the integrity of these complexes is thought to be regulated by VE-cadherin tyrosine phosphorylation. We have previously shown that adrenomedullin (AM) blockade corre
Externí odkaz:
https://doaj.org/article/213926a4514e458da5ff6110a8a97da0
Autor:
Romain Sigaud, Lisa Rösch, Charlotte Gatzweiler, Julia Benzel, Laura von Soosten, Heike Peterziel, Florian Selt, Sara Najafi, Simay Ayhan, Xenia F Gerloff, Nina Hofmann, Isabel Büdenbender, Lukas Schmitt, Kathrin I Foerster, Jürgen Burhenne, Walter E Haefeli, Andrey Korshunov, Felix Sahm, Cornelis M van Tilburg, David T W Jones, Stefan M Pfister, Deborah Knoerzer, Brent L Kreider, Max Sauter, Kristian W Pajtler, Marc Zuckermann, Ina Oehme, Olaf Witt, Till Milde
Publikováno v:
Neuro-Oncology. 25:566-579
Background Pediatric low-grade gliomas (pLGG) are the most common pediatric central nervous system tumors, with driving alterations typically occurring in the MAPK pathway. The ERK1/2 inhibitor ulixertinib (BVD-523) has shown promising responses in a
Autor:
Till Milde, Olaf Witt, Tilman Brummer, Marc Remke, David T.W. Jones, Stefan M. Pfister, Cornelis M. van Tilburg, Darren Hargrave, Tobias Rubner, Alexander C. Sommerkamp, Johanna Vollmer, Thomas Hielscher, Jonas Ecker, Stefan Pusch, Jennifer Jansen, David Pauck, Viktoria Marquardt, Florian Selt, Juliane L. Buhl, Romain Sigaud, Diren Usta
Includes the legends for Suppl. Table S1-S5.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b0453ebece66baf8ab3886add7a01a8
https://doi.org/10.1158/1535-7163.22521343.v1
https://doi.org/10.1158/1535-7163.22521343.v1
Autor:
Till Milde, Olaf Witt, Tilman Brummer, Marc Remke, David T.W. Jones, Stefan M. Pfister, Cornelis M. van Tilburg, Darren Hargrave, Tobias Rubner, Alexander C. Sommerkamp, Johanna Vollmer, Thomas Hielscher, Jonas Ecker, Stefan Pusch, Jennifer Jansen, David Pauck, Viktoria Marquardt, Florian Selt, Juliane L. Buhl, Romain Sigaud, Diren Usta
Suppl. Table S4 shows "MAPKi combinations chosen based on low estimated IC50s and pharmaceutical company in consideration of future clinical studies".
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69ac4832d809d062fcedf3a57f7029f4
https://doi.org/10.1158/1535-7163.22521349
https://doi.org/10.1158/1535-7163.22521349
Autor:
Till Milde, Olaf Witt, Tilman Brummer, Marc Remke, David T.W. Jones, Stefan M. Pfister, Cornelis M. van Tilburg, Darren Hargrave, Tobias Rubner, Alexander C. Sommerkamp, Johanna Vollmer, Thomas Hielscher, Jonas Ecker, Stefan Pusch, Jennifer Jansen, David Pauck, Viktoria Marquardt, Florian Selt, Juliane L. Buhl, Romain Sigaud, Diren Usta
Suppl. Figure S1 shows "Initial MAPKi screen using metabolic activity as readout". Suppl. Figure S2 shows "Western blot validation of MAPK pathway alterations in HEK293T cells". Suppl. Figure S3 shows "Dose-response curves of MAPKi combination treatm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::010f5ff900ab07314c3c4d69dde7540d
https://doi.org/10.1158/1535-7163.22521340.v1
https://doi.org/10.1158/1535-7163.22521340.v1
Autor:
Jonas Ecker, Florian Selt, Dominik Sturm, Martin Sill, Andrey Korshunov, Steffen Hirsch, David Capper, Nicola Dikow, Christian Sutter, Carina Müller, Romain Sigaud, Angelika Eggert, Thorsten Simon, Tim Niehues, Andreas von Deimling, Kristian W. Pajtler, Cornelis M. van Tilburg, David T.W. Jones, Felix Sahm, Stefan M. Pfister, Olaf Witt, Till Milde
Publikováno v:
European journal of cancer (Oxford, England : 1990). 180
Precision oncology requires diagnostic accuracy and robust detection of actionable alterations. The Pediatric Targeted Therapy (PTT) 2.0 program aims at improving diagnostic accuracy by addition of molecular analyses to the existing histological diag
Autor:
Florian Selt, Romain Sigaud, Gintvile Valinciute, Philipp Sievers, Julia Zaman, Clara Alcon, Simone Schmid, Heike Peterziel, Jessica W Tsai, Romain Guiho, Juan Pedro Martínez-Barbera, Stefan Pusch, Jing Deng, Yifan Zhai, Cornelis M van Tilburg, Martin U Schuhman, Ahmed El Damaty, Pratiti Bandopadhayay, Christel Herold-Mende, Andreas von Deimling, Stefan M Pfister, Joan Montero, David Capper, Ina Oehme, Felix Sahm, David T W Jones, Olaf Witt, Till Milde
Publikováno v:
Neuro-oncology.
Background Pilocytic astrocytoma (PA) is the most common pediatric brain tumor and a mitogen-activated protein kinase (MAPK)-driven disease. Oncogenic MAPK-signaling drives the majority of cells into oncogene-induced senescence (OIS). While OIS induc
Autor:
Romain, Sigaud, Lisa, Rösch, Charlotte, Gatzweiler, Julia, Benzel, Laura, von Soosten, Heike, Peterziel, Florian, Selt, Sara, Najafi, Simay, Ayhan, Xenia F, Gerloff, Nina, Hofmann, Isabel, Büdenbender, Lukas, Schmitt, Kathrin I, Foerster, Jürgen, Burhenne, Walter E, Haefeli, Andrey, Korshunov, Felix, Sahm, Cornelis M, van Tilburg, David T W, Jones, Stefan M, Pfister, Deborah, Knoerzer, Brent L, Kreider, Max, Sauter, Kristian W, Pajtler, Marc, Zuckermann, Ina, Oehme, Olaf, Witt, Till, Milde
Publikováno v:
Neuro-oncology.
Pediatric low-grade gliomas (pLGG) are the most common pediatric central nervous system tumors, with driving alterations typically occurring in the MAPK pathway. The ERK1/2 inhibitor ulixertinib (BVD-523) has shown promising responses in adult patien
Autor:
Stefan M. Pfister, Jennifer Jansen, David T.W. Jones, Darren Hargrave, Till Milde, Stefan Pusch, Diren Usta, David Pauck, Romain Sigaud, Olaf Witt, Alexander C Sommerkamp, Thomas Hielscher, Florian Selt, Viktoria Marquardt, Johanna Vollmer, Tilman Brummer, Tobias Rubner, Juliane L. Buhl, Cornelis M. van Tilburg, Jonas Ecker, Marc Remke
Publikováno v:
Molecular Cancer Therapeutics. 19:1736-1750
Pilocytic astrocytomas as well as other pediatric low-grade gliomas (pLGG) exhibit genetic events leading to aberrant activation of the MAPK pathway. The most common alterations are KIAA1549:BRAF fusions and BRAFV600E and NF1 mutations. Novel drugs t