Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Romain Mazinghien"'
Autor:
Thierry Huet, Guy Dubreucq, Romain Mazinghien, Heidi Bompais, Loïc Vincent, Maurice Petitou, Arnaud Salvador, Jérôme Lemoine, Jan Balzarini, Cécile Gauchet, Olivier Querolle, Pascal Clayette, Dominique Schols, Bruno Lucidi, Olivier Kerbarh
Publikováno v:
Antimicrobial Agents and Chemotherapy. 54:134-142
Enfuvirtide (also known as Fuzeon, T-20, or DP-178) is an antiretroviral fusion inhibitor which prevents human immunodeficiency virus type 1 (HIV-1) from entering host cells. This linear 36-mer synthetic peptide is indicated, in combination with othe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d7d17aedc7e1f5327a73158280ea973
https://doi.org/10.1128/aac.00827-09
https://doi.org/10.1128/aac.00827-09
Autor:
Patrick Hautefaye, Gilbert Lavielle, Sébastien Didier, Christian Bailly, Amélie Lansiaux, Alain Pierré, Marie-Hélène David-Cordonnier, Romain Mazinghien, Laurence Kraus-Berthier, Christine Bal-Mahieu, Stéphane Léonce, John A. Hickman
Publikováno v:
Molecular Pharmacology. 72:311-319
The E-ring lactone is the Achilles' heel of camptothecin derivatives: although it is considered necessary for the inhibition of the enzyme topoisomerase I (topo1), the opening of the lactone into a carboxylate abolishes the generation of topo1-mediat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc4d5047497a8d0995dc48e458cea9ce
https://doi.org/10.1124/mol.107.034637
https://doi.org/10.1124/mol.107.034637
Publikováno v:
European Journal of Pharmacology. 525:32-40
Sampangine is a plant-derived copyrine alkaloid extracted from the stem bark of Cananga odorata. This azaoxoaporphine alkaloid primarily exhibits antifungal and antimycobacterial activities but also displays in vitro antimalarial activity against Pla
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1cc6f00d961dd029826c5d1025f588c9
https://doi.org/10.1016/j.ejphar.2005.09.050
https://doi.org/10.1016/j.ejphar.2005.09.050
Autor:
Marie-Hélène David-Cordonnier, Francois Tillequin, Thomas Gaslonde, Quyên Do, Bruno Pfeiffer, Sabine Depauw, Sylvie Michel, Rodrigue Yougnia, Alain Pierré, Michel Koch, Hanh Dufat, Wen Tian, Laurence Kraus-Berthier, Romain Mazinghien, Amélie Lansiaux, Stéphane Léonce
Publikováno v:
Bioorganicmedicinal chemistry. 17(5)
Monocinnamoyl esters at position 2 of (±)- cis -1,2-dihydroxy-6-methoxy-3,3,14-trimethyl-1,2,3,14-tetrahydro-7 H -benzo[ b ]pyrano[3,2- h ]acridin-7-one and their acetyl derivatives at position 1 were prepared as stabilized analogues of the anticanc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18ccd26c4b7df9359bcdab8932ec6b75
https://pubmed.ncbi.nlm.nih.gov/19217791
https://pubmed.ncbi.nlm.nih.gov/19217791
Publikováno v:
Anti-cancer drugs. 17(2)
Tafluposide (F11782), an epipodophyllotoxin derivative currently undergoing phase I clinical trials, is structurally close to the established anti-cancer drug etoposide, but mechanistically distinct. It is a dual inhibitor of topoisomerases I and II
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7bdcf8df04dada4e6d66e65450fc0a88
https://pubmed.ncbi.nlm.nih.gov/16428933
https://pubmed.ncbi.nlm.nih.gov/16428933