Výsledky vyhledávání - "Romain M. Larive"

Akademický článek

Comparison of SYK Signaling Networks Reveals the Potential Molecular Determinants of Its Tumor-Promoting and Suppressing Functions

Autor: Marion Buffard, Aurélien Naldi, Gilles Freiss, Marcel Deckert, Ovidiu Radulescu, Peter J. Coopman, Romain M. Larive

Publikováno v: Biomolecules, Vol 11, Iss 2, p 308 (2021)

Spleen tyrosine kinase (SYK) can behave as an oncogene or a tumor suppressor, depending on the cell and tissue type. As pharmacological SYK inhibitors are currently evaluated in clinical trials, it is important to gain more information on the molecul

Externí odkaz: https://doaj.org/article/f0455d20d1d745b19f102be60f38537d

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La résistance aux inhibiteurs de BRAF

Autor: Cylia Dahmani, Eulalie Corre, Sarah Dandou, Alain Mangé, Ovidiu Radulescu, Peter J. Coopman, Pierre Cuq, Romain M. Larive

Publikováno v: médecine/sciences
médecine/sciences, 2022, 38 (6-7), pp.570-578. ⟨10.1051/medsci/2022083⟩

The MAPK/ERK pathway is an essential intracellular signaling pathway. Its deregulation is involved in tumor transformation and progression. The discovery of activating mutations of BRAF in various cancers has opened new therapeutic avenues with BRAF

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::871485cb5f299cfa8e0e5fa76a560bf0
https://doi.org/10.1051/medsci/2022083

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[Resistance to BRAF inhibitors: A lesson from clinical observations]

Autor: Cylia, Dahmani, Eulalie, Corre, Sarah, Dandou, Alain, Mangé, Ovidiu, Radulescu, Peter J, Coopman, Pierre, Cuq, Romain M, Larive

Publikováno v: Medecine sciences : M/S. 38(6-7)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::2b384a6d17c2babfde99a1f799bac420
https://pubmed.ncbi.nlm.nih.gov/35766855

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Comparison of SYK Signaling Networks Reveals the Potential Molecular Determinants of Its Tumor-Promoting and Suppressing Functions

Autor: Ovidiu Radulescu, Peter Coopman, Marcel Deckert, Marion Buffard, Aurélien Naldi, Gilles Freiss, Romain M. Larive

Publikováno v: Biomolecules
Biomolecules, MDPI, 2021, 11 (2), pp.308. ⟨10.3390/biom11020308⟩
Biomolecules, 2021, 11 (2), pp.308. ⟨10.3390/biom11020308⟩
Volume 11
Issue 2
Biomolecules, Vol 11, Iss 308, p 308 (2021)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0138c724f6e50d39f8ed56133a6d807e
https://hal-cnrs.archives-ouvertes.fr/hal-03160560/file/biomolecules-11-00308-v2.pdf

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Imidazo[1,2-a]quinoxalines for melanoma treatment with original mechanism of action

Autor: Carine Deleuze-Masquéfa, Kamel Hadj Kaddour, Pierre Cuq, Zahraa Zghaib, Cindy Patinote, Mona Diab Assaf, Laure-Anaïs Vincent, Pierre-Antoine Bonnet, Romain M. Larive, Jean-François Guichou

Publikováno v: European journal of medicinal chemistry. 212

The malignant transformation of melanocytes causes several thousand deaths each year, making melanoma an important public health concern. Melanoma is the most aggressive skin cancer, which incidence has regularly increased over the past decades. We d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7fcf57d0cba9e1394c97c8471cc66d6
https://pubmed.ncbi.nlm.nih.gov/33309473

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PTPN13 induces cell junction stabilization and inhibits mammary tumor invasiveness

Autor: Gilles Freiss, Joelle Simony-Lafontaine, Aurélien Naldi, Romain M. Larive, Carole Puech, Mohamed Hamyeh, Florence Bernex, William Bakhache, Jérôme Solassol, Wiljan Hendriks, Serge Urbach, Peter Coopman

Publikováno v: Theranostics
Theranostics, Ivyspring International Publisher, In press, 10 (3), pp.1016-1032. ⟨10.7150/thno.38537⟩
Theranostics, 10, 1016-1032
Theranostics, 10, 3, pp. 1016-1032
Theranostics, In press, 10 (3), pp.1016-1032. ⟨10.7150/thno.38537⟩

International audience; Clinical data suggest that the protein tyrosine phosphatase PTPN13 exerts an anti-oncogenic effect. Its exact role in tumorigenesis remains, however, unclear due to its negative impact on FAS receptor-induced apoptosis. Method

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5473c950a8aaeb5524e371da79625eba
https://hdl.handle.net/https://repository.ubn.ru.nl/handle/2066/214494

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The Syk Kinase Promotes Mammary Epithelial Integrity and Inhibits Breast Cancer Invasion by Stabilizing the E-Cadherin/Catenin Complex

Autor: Nadir Bettache, Fabrice Merezegue, Jérôme Solassol, Ma Cleofas Marcial Medina, Florence Boissière-Michot, Anne Morel, Gilles Freiss, Marion Peter, Peter Coopman, Serge Urbach, Romain M. Larive, Philippe Montcourrier, Toufic Kassouf

Publikováno v: Cancers
Cancers, MDPI, 2019, 11 (12), pp.1974. ⟨10.3390/cancers11121974⟩
Volume 11
Issue 12
Cancers, 2019, 11 (12), pp.1974. ⟨10.3390/cancers11121974⟩

While first discovered in immunoreceptor signaling, the Syk protein kinase behaves as a tumor and metastasis suppressor in epithelial cells. Its reduced expression in breast and other carcinomas is correlated with decreased survival and increased met

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e13ee4a751c2fc8c2977f88d14d6aa6
https://hal.archives-ouvertes.fr/hal-02401110/file/cancers-11-01974-v2.pdf

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Network Reconstruction and Significant Pathway Extraction Using Phosphoproteomic Data from Cancer Cells

Autor: Gilles Freiss, Marion Buffard, Romain M. Larive, Peter Coopman, Ovidiu Radulescu, Aurélien Naldi

Publikováno v: Proteomics
Proteomics, Wiley-VCH Verlag, 2019, 19 (21-22), pp.1800450. ⟨10.1002/pmic.201800450⟩
Proteomics, 2019, 19 (21-22), pp.1800450. ⟨10.1002/pmic.201800450⟩

Protein phosphorylation acts as an efficient switch controlling deregulated key signaling pathway in cancer. Computational biology aims to address the complexity of reconstructed networks but overrepresents well-known proteins and lacks information o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc5ed367de3b329fd642a22a3eab4ac8
https://hal.archives-ouvertes.fr/hal-03049205/document

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Vav proteins maintain epithelial traits in breast cancer cells using miR-200c-dependent and independent mechanisms

Autor: Carmen Citterio, Jesús M. Paramio, L. Francisco Lorenzo-Martín, Pedro M. Fernández-Salguero, Romain M. Larive, Javier Robles-Valero, Javier Conde, Xosé R. Bustelo, María J. Montero, Myriam Cuadrado, Mauricio Menacho-Márquez, Mª Ángeles Sevilla, Isabel Fernández-Pisonero, Sonia Rodríguez-Fdez, Mercedes Dosil, Ramón García-Escudero

Publikováno v: Digital.CSIC. Repositorio Institucional del CSIC
instname
Oncogene

The bidirectional regulation of epithelial–mesenchymal transitions (EMT) is key in tumorigenesis. Rho GTPases regulate this process via canonical pathways that impinge on the stability of cell-to-cell contacts, cytoskeletal dynamics, and cell invas

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::469910d984fe5688feeee1cb2c4772cc
http://hdl.handle.net/10261/204097

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Contribution of the R-Ras2 GTP-binding protein to primary breast tumorigenesis and late-stage metastatic disease

Autor: Xosé R. Bustelo, Giulia Moriggi, Marta Cañamero, Mauricio Menacho-Márquez, Mercedes Dosil, Balbino Alarcón, Romain M. Larive, Enrique de Alava

Publikováno v: CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
Digital.CSIC. Repositorio Institucional del CSIC
instname
Nature Communications
Nature Communications, Nature Publishing Group, 2014, 5, pp.3881. ⟨10.1038/ncomms4881⟩

R-Ras2 is a transforming GTPase that shares downstream effectors with Ras subfamily proteins. However, little information exists about the function of this protein in tumorigenesis and its signalling overlap with classical Ras GTPases. Here we show,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9cd47796cddd8a852f1882045dab9e61
https://www.nature.com/articles/ncomms4881

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