Comparison of SYK Signaling Networks Reveals the Potential Molecular Determinants of Its Tumor-Promoting and Suppressing Functions

Autor: Marion Buffard, Aurélien Naldi, Gilles Freiss, Marcel Deckert, Ovidiu Radulescu, Peter J. Coopman, Romain M. Larive

Publikováno v: Biomolecules, Vol 11, Iss 2, p 308 (2021)

Spleen tyrosine kinase (SYK) can behave as an oncogene or a tumor suppressor, depending on the cell and tissue type. As pharmacological SYK inhibitors are currently evaluated in clinical trials, it is important to gain more information on the molecul

Externí odkaz: https://doaj.org/article/f0455d20d1d745b19f102be60f38537d

[Resistance to BRAF inhibitors: A lesson from clinical observations]

Autor: Cylia, Dahmani, Eulalie, Corre, Sarah, Dandou, Alain, Mangé, Ovidiu, Radulescu, Peter J, Coopman, Pierre, Cuq, Romain M, Larive

Publikováno v: Medecine sciences : M/S. 38(6-7)

The MAPK/ERK pathway is an essential intracellular signaling pathway. Its deregulation is involved in tumor transformation and progression. The discovery of activating mutations of BRAF in various cancers has opened new therapeutic avenues with BRAF

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::2b384a6d17c2babfde99a1f799bac420
https://pubmed.ncbi.nlm.nih.gov/35766855

Imidazo[1,2-a]quinoxalines for melanoma treatment with original mechanism of action

Autor: Carine Deleuze-Masquéfa, Kamel Hadj Kaddour, Pierre Cuq, Zahraa Zghaib, Cindy Patinote, Mona Diab Assaf, Laure-Anaïs Vincent, Pierre-Antoine Bonnet, Romain M. Larive, Jean-François Guichou

Publikováno v: European journal of medicinal chemistry. 212

The malignant transformation of melanocytes causes several thousand deaths each year, making melanoma an important public health concern. Melanoma is the most aggressive skin cancer, which incidence has regularly increased over the past decades. We d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7fcf57d0cba9e1394c97c8471cc66d6
https://pubmed.ncbi.nlm.nih.gov/33309473

The Syk Kinase Promotes Mammary Epithelial Integrity and Inhibits Breast Cancer Invasion by Stabilizing the E-Cadherin/Catenin Complex

Autor: Nadir Bettache, Fabrice Merezegue, Jérôme Solassol, Ma Cleofas Marcial Medina, Florence Boissière-Michot, Anne Morel, Gilles Freiss, Marion Peter, Peter Coopman, Serge Urbach, Romain M. Larive, Philippe Montcourrier, Toufic Kassouf

Publikováno v: Cancers
Cancers, MDPI, 2019, 11 (12), pp.1974. ⟨10.3390/cancers11121974⟩
Volume 11
Issue 12
Cancers, 2019, 11 (12), pp.1974. ⟨10.3390/cancers11121974⟩

While first discovered in immunoreceptor signaling, the Syk protein kinase behaves as a tumor and metastasis suppressor in epithelial cells. Its reduced expression in breast and other carcinomas is correlated with decreased survival and increased met

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e13ee4a751c2fc8c2977f88d14d6aa6
https://hal.archives-ouvertes.fr/hal-02401110/file/cancers-11-01974-v2.pdf

Contribution of the R-Ras2 GTP-binding protein to primary breast tumorigenesis and late-stage metastatic disease

Autor: Xosé R. Bustelo, Giulia Moriggi, Marta Cañamero, Mauricio Menacho-Márquez, Mercedes Dosil, Balbino Alarcón, Romain M. Larive, Enrique de Alava

Publikováno v: CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
Digital.CSIC. Repositorio Institucional del CSIC
instname
Nature Communications
Nature Communications, Nature Publishing Group, 2014, 5, pp.3881. ⟨10.1038/ncomms4881⟩

R-Ras2 is a transforming GTPase that shares downstream effectors with Ras subfamily proteins. However, little information exists about the function of this protein in tumorigenesis and its signalling overlap with classical Ras GTPases. Here we show,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9cd47796cddd8a852f1882045dab9e61
https://www.nature.com/articles/ncomms4881