Could a Multi-Marker and Machine Learning Approach Help Stratify Patients with Heart Failure?

Autor: François Roubille, Sylvain Richard, Jean-Paul Cristol, Anne-Marie Dupuy, Manuela Lotierzo, Amanda Finan-Marchi, Jérôme Adda, Fabien Huet, David Piquemal, Glaucy Rodrigues, Eran Kalmanovich, Romain Bruno

Publikováno v: Medicina
Medicina, 2021, 57 (10), pp.996. ⟨10.3390/medicina57100996⟩
Medicina, MDPI, 2021, 57 (10), pp.996. ⟨10.3390/medicina57100996⟩
Medicina, Vol 57, Iss 996, p 996 (2021)

International audience; Half of the patients with heart failure (HF) have preserved ejection fraction (HFpEF). To date, there are no specific markers to distinguish this subgroup. The main objective of this work was to stratify HF patients using curr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f9e3c062df21100f92c291fd9602bad4
https://doi.org/10.3390/medicina57100996

Dictyostelium discoideum: a model host to measure bacterial virulence

Autor: Anna Marchetti, Emmanuelle Lelong, Pierre Cosson, Romain Bruno Froquet

Publikováno v: Nature Protocols, Vol. 4, No 1 (2009) pp. 25-30

Dictyostelium amoebae have been used as a host model to measure virulence of a wide range of bacterial pathogens. The simple protocol described here takes advantage of the ability of Dictyostelium to grow and form plaques on a lawn of nonpathogenic b

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37135cbb60cbd29919abd771adb21441
https://doi.org/10.1038/nprot.2008.212

A Phg2-Adrm1 Pathway Participates in the Nutrient-controlled Developmental Response inDictyostelium

Autor: Pierre Cosson, Steve J. Charette, Cédric Blanc, Nathalie Cherix, François Letourneur, Romain Bruno Froquet

Publikováno v: Molecular Biology of the Cell, Vol. 17, No 12 (2006) pp. 4982-7

Dictyostelium amoebae grow as single cells but upon starvation they initiate multicellular development. Phg2 was characterized previously as a kinase controlling cellular adhesion and the organization of the actin cytoskeleton. Here we report that Ph

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6858d89c59d1c8d7d6aeccef542906a
https://doi.org/10.1091/mbc.e06-07-0619

Control of cellular physiology by TM9 proteins in yeast and Dictyostelium

Autor: Nathalie Cherix, Raphael Birke, Hans-Ulrich Mösch, Mohammed Benghezal, Romain Bruno Froquet, Claudio De Virgilio, Elisabetta Cameroni, Pierre Cosson, François Letourneur

Publikováno v: Journal of Biological Chemistry, Vol. 283, No 11 (2008) pp. 6764-72

TM9 proteins constitute a well defined family, characterized by the presence of a large variable extracellular domain and nine putative transmembrane domains. This family is highly conserved throughout evolution and comprises three members in Dictyos

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18237224096336fa9678ab63b93b36bb
https://pubmed.ncbi.nlm.nih.gov/18178563

Specific host genes required for the killing of Klebsiella bacteria by phagocytes

Autor: Romain Bruno Froquet, Anna Marchetti, Régis Tournebize, Pierre Cosson, Philippe J. Sansonetti, Steve J. Charette, Marie-Odile Fauvarque, Evelyne Bergeret, Mohammed Benghezal, Bernard Lardy, Gérard Klein

Publikováno v: Cellular Microbiology, Vol. 8, No 1 (2006) pp. 139-48
Cellular Microbiology
Cellular Microbiology, Wiley, 2006, 8 (1), pp.139-48. ⟨10.1111/j.1462-5822.2005.00607.x⟩
Cellular Microbiology, 2006, 8 (1), pp.139-48. ⟨10.1111/j.1462-5822.2005.00607.x⟩

International audience; The amoeba Dictyostelium discoideum shares many traits with mammalian macrophages, in particular the ability to phagocytose and kill bacteria. In response, pathogenic bacteria use conserved mechanisms to fight amoebae and mamm

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93dd8d8fb534047a66550cac56664e35
https://archive-ouverte.unige.ch/unige:39521