Aluminum Acetals in Organic Synthesis

Autor: Anne Boussonnière, Jacques Lebreton, Fabrice Dénès, Romain Bénéteau

Publikováno v: European Journal of Organic Chemistry. 2013:7853-7866

Aluminum acetals are easily obtained from esters and lactones by reduction with aluminum hydrides. These thermally unstable tetrahedral intermediates have found applications in organic synthesis, with various methodologies taking advantage both of th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::738bb3b54386e9e942ca2ef49284f9fd
https://doi.org/10.1002/ejoc.201300624

A Convenient Access to γ‐Lactones from O ‐Allyl‐α‐Bromoesters using a One‐Pot Ionic–Radical–Ionic Sequence

Autor: Romain Bénéteau, Jacques Lebreton, Fabrice Dénès

Publikováno v: Chemistry – An Asian Journal. 7:1516-1520

Cognac in the jar! An efficient one-pot sequence for the preparation of γ-lactones is described. Following reduction of α-bromo ester precursors with DIBAL-H and radical cyclization of the resulting O-aluminum acetals, a preparative in-situ Oppenau

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ca522c21686fa2a9247d99edea00c4f
https://doi.org/10.1002/asia.201200212

ChemInform Abstract: Synthesis of Polysubstituted γ-Butenolides via a Radical Pathway: Cyclization of α-Bromo Aluminium Acetals and Comparison with the Cyclization of α-Bromoesters at High Temperature

Autor: Carole F. Despiau, Fabrice Dénès, Romain Bénéteau, Jean-Christophe Rouaud, Virginie Silvestre, Anne Boussonnière, Jacques Lebreton

Publikováno v: ChemInform. 46

A four-step one-pot procedure involving generation of α-bromo aluminum acetals, their subsequent radical cyclization followed by oxidation of the resulting cyclic aluminum acetals and base promoted double bond migration is developed to convert α-br

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c7a441c372ba0ba5b9e2b22c80068e27
https://doi.org/10.1002/chin.201551107

Synthesis of new pyridazino[4,5-b]indol-4-ones and pyridazin-3(2H)-one analogs as DYRK1A inhibitors

Autor: Cédric Logé, Olivier Lozach, Laurent Meijer, H. Bénédetti, Romain Bénéteau, Jean-Michel Robert, Rémy Le Guével, Myriam Ravache, Amélie Bruel, Mylène Chabanne

Publikováno v: Bioorganic and Medicinal Chemistry Letters
Bioorganic and Medicinal Chemistry Letters, Elsevier, 2014, 24 (21), pp.5037-5040. ⟨10.1016/j.bmcl.2014.09.017⟩
Bioorganic and Medicinal Chemistry Letters, 2014, 24 (21), pp.5037-5040. ⟨10.1016/j.bmcl.2014.09.017⟩

International audience; New pyridazino[4,5-b]indol-4-ones and pyridazin-3(2H)-one analogs were synthesized and their inhibitory activities against DYRK1A, CDK5/p25, GSK3α/β and p110-α isoform of PI3K evaluated using harmine as reference. Both fura

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::beade993229cb76ec189dfaaf5f39579
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01086026

ChemInform Abstract: A Convenient Access to γ-Lactones from O-Allyl-α-Bromoesters Using a One-Pot Ionic-Radical-Ionic Sequence

Autor: Jacques Lebreton, Romain Bénéteau, Fabrice Dénès

Publikováno v: ChemInform. 43

In continuation of recently published studies on the cyclization of in situ generated α-bromo aluminum acetals, an efficient protocol for preparation of γ-lactones is presented.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6a9d672a985056c03dcb90e78ff335dd
https://doi.org/10.1002/chin.201246107