Axin1 Protects Colon Carcinogenesis by an Immune-Mediated EffectSummary

Autor: Romain Sanson, Silvia Luna Lazzara, David Cune, Caterina Luana Pitasi, Coralie Trentesaux, Marie Fraudeau, Franck Letourneur, Benjamin Saintpierre, Morgane Le Gall, Pascale Bossard, Benoit Terris, Pascal Finetti, François Bertucci, Emilie Mamessier, Béatrice Romagnolo, Christine Perret

Publikováno v: Cellular and Molecular Gastroenterology and Hepatology, Vol 15, Iss 3, Pp 689-715 (2023)

Background & Aims: Axin1 is a negative regulator of wingless-type MMTV integration site family, member 1 (Wnt)/β-catenin signaling with tumor-suppressor function. The Wnt pathway has a critical role in the intestine, both during homeostasis and canc

Externí odkaz: https://doaj.org/article/4a72234f38544a578451fba6ef5a091b

AXIN deficiency in human and mouse hepatocytes induces hepatocellular carcinoma in the absence of β-catenin activation

Autor: Mathilde Savall, Pierre-Alexandre Just, Bernhard Mlecnik, Benoit Terris, Florent Dumont, Mireille Vasseur-Cognet, Valerie Drouet, Pierre Sohier, Romain Sanson, Bruno Ragazzon, Pascale Bossard, Julien Calderaro, Cédric Coulouarn, Hélène Gilgenkrantz, Rajae Dahmani, Emilie Tournier, Shirley Abitbol, Nadia Senni, Jessica Zucman-Rossi, Christine Perret

Publikováno v: Journal of Hepatology
Journal of Hepatology, 2018, 68 (6), pp.1203-1213. ⟨10.1016/j.jhep.2017.12.018⟩
Journal of Hepatology, Elsevier, 2018, 68 (6), pp.1203-1213. ⟨10.1016/j.jhep.2017.12.018⟩
Journal of Hepatology, 2018, 68 (6), pp.1203-1213. 〈10.1016/j.jhep.2017.12.018〉

Background & Aims The Wnt/β-catenin pathway is the most frequently deregulated pathway in hepatocellular carcinoma (HCC). Inactivating mutations of the gene encoding AXIN1, a known negative regulator of the Wnt/β-catenin signaling pathway, are obse

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a6ba3105ddc678d0e390666ba0d098b
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01807225