Výsledky vyhledávání - "Romain, Brunel"

KKL-35 Exhibits Potent Antibiotic Activity against Legionella Species Independently of

Autor: Romain, Brunel, Ghislaine, Descours, Isabelle, Durieux, Patricia, Doublet, Sophie, Jarraud, Xavier, Charpentier

Publikováno v: Antimicrobial Agents and Chemotherapy

trans-Translation is a ribosome-rescue system that is ubiquitous in bacteria. Small molecules defining a new family of oxadiazole compounds that inhibit trans-translation have been found to have broad-spectrum antibiotic activity. We sought to determ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::592e77f8c5fc3b517dc64abba5b42885
https://pubmed.ncbi.nlm.nih.gov/29158279

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KKL-35 exhibits potent antibiotic activity against Legionella species independently of trans-translation inhibition

Autor: Sophie Jarraud, Patricia Doublet, Isabelle Durieux, Xavier Charpentier, Ghislaine Descours, Romain Brunel

Publikováno v: Antimicrobial Agents and Chemotherapy
Antimicrobial Agents and Chemotherapy, 2018, 62 (2), ⟨10.1128/AAC.01459-17⟩
Antimicrobial Agents and Chemotherapy, American Society for Microbiology, 2018, 62 (2), ⟨10.1128/AAC.01459-17⟩

Trans-translation is a ribosome rescue system that is ubiquitous in bacteria. Small molecules defining a new family of oxadiazole compounds that inhibit trans-translation have been found to have broad-spectrum antibiotic activity. We sought to determ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e11e9be769b77f885fb199ea195b624

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Trans-translation is essential in the human pathogen Legionella pneumophila

Autor: Romain Brunel, Xavier Charpentier

Publikováno v: Scientific Reports
Scientific Reports, 2016, 6, pp.37935. ⟨10.1038/srep37935⟩
Scientific Reports, Nature Publishing Group, 2016, 6, pp.37935. ⟨10.1038/srep37935⟩

Trans-translation is a ubiquitous bacterial mechanism for ribosome rescue in the event of translation stalling. Although trans-translation is not essential in several bacterial species, it has been found essential for viability or virulence in a wide

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Random mutagenesis of the hyperthermophilic archaeon Pyrococcus furiosus using in vitro mariner transposition and natural transformation

Autor: Gina L. Lipscomb, Xavier Charpentier, Maxime Tourte, Natalia Guschinskaya, Philippe Oger, Michael W. W. Adams, Romain Brunel

Publikováno v: Scientific Reports
Scientific Reports, 2016, 6, pp.36711. ⟨10.1038/srep36711⟩
Scientific Reports, Nature Publishing Group, 2016, 6, pp.36711. ⟨10.1038/srep36711⟩

Transposition mutagenesis is a powerful tool to identify the function of genes, reveal essential genes and generally to unravel the genetic basis of living organisms. However, transposon-mediated mutagenesis has only been successfully applied to a li

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