Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Romain, Bejot"'
Publikováno v:
Journal of Nuclear Medicine. 54:1630-1636
Successful antiangiogenic therapies have been developed for the treatment of various cancers, but not all patients respond. Therefore, the early determination of therapy efficacy is essential for patient management. This study was done to evaluate th
Publikováno v:
Journal of Labelled Compounds and Radiopharmaceuticals. 56:42-49
Integrins have become increasingly attractive targets for molecular imaging of angiogenesis with positron emission tomography or single-photon emission computed tomography, but the reliable production of radiopharmaceuticals remains challenging. A st
Autor:
Véronique Gouverneur, Jerome Declerck, Laurence Carroll, Sophie Boldon, Romain Bejot, Jane E. Moore
The Staudinger ligation of phosphine-substituted thioesters with (18)F-fluoroethylazide has been successfully applied to access (18)F-labelled molecules in radiochemical yields superior to 95%; the first fluorous variant of a Staudinger radio-ligatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bfcd7d55bd581d8a1d119e2cee776fd5
https://ora.ox.ac.uk/objects/uuid:b650447f-461c-4608-9240-69cd4ebecbf0
https://ora.ox.ac.uk/objects/uuid:b650447f-461c-4608-9240-69cd4ebecbf0
Radiopharmaceuticals for nuclear imaging are essentially targeting molecules, labeled with short-lived radionuclides (e.g., F-18 for PET). A significant drawback of radiopharmaceuticals development is the difficulty to access radiolabeled molecule li
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c2be23d90d3e5e29710dd47f5f15838
https://doi.org/10.1016/j.bmc.2011.10.084
https://doi.org/10.1016/j.bmc.2011.10.084
Autor:
Matthew N. Hopkinson, Romain Bejot, Rodrigue Leuma Yona, Véronique Gouverneur, Antony D. Gee, Lei Li
The availability of radiolabelled probes is important for in vivo studies by positron emission tomography (PET). Among the frontier challenges in 18F-radiochemistry are the interconnected goals of increasing synthetic efficiency and diversity in the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::97d295a4e4e91bd02e9104022c05b920
https://ora.ox.ac.uk/objects/uuid:8dcf752e-70be-4d67-944b-0d879513e32e
https://ora.ox.ac.uk/objects/uuid:8dcf752e-70be-4d67-944b-0d879513e32e
Autor:
Jonathan R. Dilworth, Rebekka Hueting, Paul D. Bonnitcha, Jerome Declerck, Véronique Gouverneur, Robert King, Martin Christlieb, Laurence Carroll, Simon R. Bayly, Antony D. Gee, Romain Bejot
The synthesis of three pairs of orthogonally labelled fluorinated Cu bis(thiosemicarbazonato) complexes is presented. These are the first examples of (18)F-labelled Cu(II)-complexes designed to serve as new hypoxia selective PET tracers and as mechan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f99748e7303710c88adf4c8346505ab3
https://ora.ox.ac.uk/objects/uuid:5f2bb234-11cf-420a-9a81-d76559dbe3ba
https://ora.ox.ac.uk/objects/uuid:5f2bb234-11cf-420a-9a81-d76559dbe3ba
Autor:
Seval, Beykan, Jan S, Dam, Uta, Eberlein, Jens, Kaufmann, Benedict, Kjærgaard, Lars, Jødal, Hakim, Bouterfa, Romain, Bejot, Michael, Lassmann, Svend Borup, Jensen
Publikováno v:
EJNMMI Research
Background 177Lu is used in peptide receptor radionuclide therapies for the treatment of neuroendocrine tumors. Based on the recent literature, SST2 antagonists are superior to agonists in tumor uptake. The compound OPS201 is the novel somatostatin a
Publikováno v:
Journal of Labelled Compounds and Radiopharmaceuticals. 55:346-353
Antibody-targeted nuclear imaging or radiotherapy rely on chemical modification of the polypeptide backbone that may hamper the antigen binding and hence the targeting ability. In this study, we examine a strategy for covalent modification and radiol
Publikováno v:
Current Pharmaceutical Biotechnology. 12:528-538
Breast cancer is increasing at an alarming rate in women around the world, where medical biology is confronted by this disease on two crucial fronts. The first step is the early accurate diagnosis, which is very critical and the second step involves
Batch-mode microfluidic radiosynthesis of N-succinimidyl-4-[18F]fluorobenzoate for protein labelling
Autor:
Hartmuth C. Kolb, Ed Ball, Véronique Gouverneur, Reza Miraghaie, Romain Bejot, Arkadij M. Elizarov, Jianzhong Zhang
Publikováno v:
Journal of Labelled Compounds and Radiopharmaceuticals. 54:117-122
The batch microfluidic technology is a promising system for sequential chemical steps combining the advantages of micro-scale reactions, while addressing some shortcomings of flow-through systems. We report herein the convenient three-step, one-pot s