Zobrazeno 1 - 10
of 155
pro vyhledávání: '"Roma Sehmi"'
Autor:
Christiane E. Whetstone, BSc, Ruth P. Cusack, MB, MPH, Emma Price, MSc, Karen Howie, Catie Stevens, BSc, Dhuha Al-Sajee, MD, PhD, Sue Beaudin, BSc, Jennifer Wattie, Nadia Alsaji, MBChB, Abbey Schlatman, BSc, Vanessa Luk, BHSc, Xiaotian Ju, PhD, Paul O’Byrne, MB, Mark Inman, MD, PhD, Roma Sehmi, PhD, Hermenio Lima, MD, PhD, Gail M. Gauvreau, PhD
Publikováno v:
Journal of Allergy and Clinical Immunology: Global, Vol 3, Iss 4, Pp 100310- (2024)
Background: Atopic dermatitis (AD) is a skin barrier dysfunction characterized by tissue eosinophilia. Objective: In patients with AD, we evaluated the effect of eosinophil depletion with benralizumab on markers of inflammation in skin after intrader
Externí odkaz:
https://doaj.org/article/6a842f379659480d957c7c5a1c8f6866
Autor:
Maral Ranjbar, Ruth P. Cusack, Christiane E. Whetstone, Danica L. Brister, Jennifer Wattie, Lesley Wiltshire, Nadia Alsaji, Jennifer Le Roux, Eric Cheng, Thivya Srinathan, Terence Ho, Roma Sehmi, Paul M. O’Byrne, Maryonne Snow-Smith, Michelle Makiya, Amy D. Klion, MyLinh Duong, Gail M. Gauvreau
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 12, p 6427 (2024)
Background: The immune response dynamics in COVID-19 patients remain a subject of intense investigation due to their implications for disease severity and treatment outcomes. We examined changes in leukocyte levels, eosinophil activity, and cytokine
Externí odkaz:
https://doaj.org/article/fda2923a573a441882051699bd42c621
Autor:
Xiaotian Ju, Kiho Son, Rameen Jamil, Sarah Culgin, Brittany Salter, Kate Miyasaki, Nahal Emami Fard, Maria Xiao, Zil Patel, Kayla Zhang, Braeden Cowbrough, Melanie Kjarsgaard, Katherine Radford, Anna Dvorkin-Gheva, Carl D. Richards, Gerard Cox, Zain Chagla, Marek Smieja, Marcel Tunks, Waleed Alhazzani, Dawn M.E. Bowdish, Dan Perri, Parameswaran K. Nair, Roma Sehmi, Manali Mukherjee
Publikováno v:
Allergy, Asthma & Clinical Immunology, Vol 19, Iss 1, Pp 1-4 (2023)
Externí odkaz:
https://doaj.org/article/cf86cc4b0ca34fecac9b0c5c7164a921
Publikováno v:
Biomolecules, Vol 14, Iss 3, p 294 (2024)
Eosinophilic asthma is the most prevalent and well-defined phenotype of asthma. Despite a majority of patients responding to corticosteroid therapy and T2 biologics, there remains a subset that have recurrent asthma exacerbations, highlighting a need
Externí odkaz:
https://doaj.org/article/b6eb6ef4a6c84e84ac0164ed15713474
Publikováno v:
Cells, Vol 12, Iss 21, p 2556 (2023)
Over the past two decades, a growing body of evidence observations have shown group two innate lymphoid cells (ILC2) to be critical drivers of Type 2 (T2) inflammatory responses associated with allergic inflammatory conditions such as asthma. ILC2 re
Externí odkaz:
https://doaj.org/article/1fe1a4ee0a534acebf14f194c61b7346
Autor:
Maral Ranjbar, Ruth P. Cusack, Christiane E. Whetstone, Shiraz Nawaz, Christopher Khoury, Jennifer Wattie, Lesley Wiltshire, Jennifer Le Roux, Eric Cheng, Thivya Srinathan, Terence Ho, Roma Sehmi, MyLinh Duong, Gail M. Gauvreau
Publikováno v:
Genes, Vol 14, Iss 9, p 1721 (2023)
Background: The immune response in COVID-19 is characterized by the release of alarmin cytokines, which play crucial roles in immune activation and inflammation. The interplay between these cytokines and genetic variations may influence disease sever
Externí odkaz:
https://doaj.org/article/df02af94c1024b688cf18073010edaf9
Autor:
Chen Zhan, Rong Xu, Bizhou Li, Jiaxing Liu, Wanqin Liang, Shengfang Zhang, Liman Fang, Shuxin Zhong, S. Dushinka Shaniya Helen de Silva, Dhinesan Sivapalan, Wei Luo, Jing Li, Kefang Lai, Nanshan Zhong, Roma Sehmi, Paul M. O’Byrne, Ruchong Chen
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
ObjectiveThis study aims to explore the potential of in situ airway differentiation of eosinophil progenitors (EoPs) and hematopoietic progenitor cells (HPCs) in sputum and peripheral blood from patients with non-asthmatic eosinophilic bronchitis (NA
Externí odkaz:
https://doaj.org/article/f426ac6d95754e7ca084270c398cabf1
Autor:
Wei Tang, Steven G. Smith, Wei Du, Akash Gugilla, Juan Du, John Paul Oliveria, Karen Howie, Brittany M. Salter, Gail M. Gauvreau, Paul M. O’Byrne, Roma Sehmi
Publikováno v:
Clinical and Translational Allergy, Vol 8, Iss 1, Pp 1-9 (2018)
Abstract Background Eosinophil-lineage committed progenitor cells (EoP) migrate from the bone marrow and differentiate locally to provide an ongoing source of mature eosinophils in asthmatic inflammatory responses in the airways. Sputum levels of EoP
Externí odkaz:
https://doaj.org/article/8fd1546f13c646bd9866d47241a18e2f
Publikováno v:
Cells, Vol 10, Iss 2, p 412 (2021)
Eosinophilic asthma is the most prevalent phenotype of asthma. Although most asthmatics are adequately controlled by corticosteroid therapy, a subset (5–10%) remain uncontrolled with significant therapy-related side effects. This indicates the need
Externí odkaz:
https://doaj.org/article/f5a6663f6b2443aca4e2773e5534b3eb
Publikováno v:
Cells, Vol 10, Iss 1, p 157 (2021)
The magnitude of eosinophil mobilization into respiratory tissues drives the severity of inflammation in several airway diseases. In classical models of leukocyte extravasation, surface integrins undergo conformational switches to high-affinity state
Externí odkaz:
https://doaj.org/article/01591b7a075f4cc68edd5709f21d15d8