Výsledky vyhledávání - "Rolly G. Fuentes"

Structure Elucidation and Confirmation of Phloroglucinols from the Roots of Garcinia dauphinensis by Comparison of Experimental and Calculated ECD Spectra and Specific Rotations

Autor: Kirk C. Pearce, T. Daniel Crawford, Rolly G. Fuentes, David G. I. Kingston, Rageshwari Marolikar, Susana Calderon

Publikováno v: Journal of Natural Products. 84:1163-1174

Eight phloroglucinols from Garcinia dauphinensis were recently reported to have good to moderate antiplasmodial and anticancer activities, consistent with other phloroglucinol derivatives isolated from natural sources. Chiroptical properties were pre

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ba4a66daa57b785896c71616618a9aaa
https://doi.org/10.1021/acs.jnatprod.0c01208

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Phloroglucinols from the Roots of Garcinia dauphinensis and Their Antiproliferative and Antiplasmodial Activities

Autor: Maria B. Cassera, Ana Lisa Valenciano, Rolly G. Fuentes, Andriamalala Rakotondrafara, T. Daniel Crawford, Yongle Du, Kirk C. Pearce, David G. I. Kingston, Vincent E. Rasamison

Publikováno v: Journal of Natural Products. 82:431-439

Garcinia dauphinensis is a previously uninvestigated endemic plant species of Madagascar. The new phloroglucinols dauphinols A-F and 3'-methylhyperjovoinol B (1-7) and six known phloroglucinols (8-13) together with tocotrienol 14 and three triterpeno

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6e4d4733956aff388120ebef5b2daaa
https://doi.org/10.1021/acs.jnatprod.8b00379

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Scopadulciol, Isolated from Scoparia dulcis, Induces β-Catenin Degradation and Overcomes Tumor Necrosis Factor-Related Apoptosis Ligand Resistance in AGS Human Gastric Adenocarcinoma Cells

Autor: Samir Kumar Sadhu, Firoj Ahmed, Kazufumi Toume, Masami Ishibashi, Rolly G. Fuentes, Midori A. Arai

Publikováno v: Journal of Natural Products. 78:864-872

Scopadulciol (1), a scopadulan-type diterpenoid, was isolated from Scoparia dulcis along with three other compounds (2-4) by an activity-guided approach using the TCF reporter (TOP) luciferase-based assay system. A fluorometric microculture cytotoxic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0bbedf1c5d4f14a0c4376c22efab8410
https://doi.org/10.1021/np500933v

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Limonoids with Wnt signal inhibitory activity isolated from the fruits of Azadirachta excelsa

Autor: Masami Ishibashi, Kazufumi Toume, Samir Kumar Sadhu, Midori A. Arai, Rolly G. Fuentes, Firoj Ahmed

Publikováno v: Phytochemistry Letters. 11:280-285

A B S T R A C T The Wnt signal regulates various biological processes, and its aberrant activation is associated with the development of diseases. Thus, inhibiting the Wnt signal provides a promising strategy to treat these diseases. Our cell-based l

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::575138fec6002011621041b3fc72794f
https://doi.org/10.1016/j.phytol.2015.01.015

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Synthesis of rocaglamide derivatives and evaluation of their Wnt signal inhibitory activities

Autor: Utpal Kumar Karmakar, Kazuki Yamaku, Masami Ishibashi, Yuuki Tanaka, Rolly G. Fuentes, Midori A. Arai, Natsuki Yanase, Yuuki Kofuji

Publikováno v: Organicbiomolecular chemistry. 14(11)

Rocaglamides are bioactive natural compounds which have a cyclopenta[b]benzofuran core structure. The total synthesis of a reported natural product, 3′-hydroxymethylrocaglate (5), was achieved using [3 + 2] cycloaddition between 3-hydroxyflavone an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73774c75a77eae4f75dbcd0e4171d893
https://pubmed.ncbi.nlm.nih.gov/26893289

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Natural compounds with Wnt signal modulating activity

Autor: Midori A. Arai, Masami Ishibashi, Rolly G. Fuentes

Publikováno v: Natural product reports. 32(12)

Covering: up to 2015 The Wnt signalling pathway is essential in many biological processes. The Wnt signal is associated with several diseases, particularly cancer and neurodegenerative diseases. Recently, high-throughput screening systems have been d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1757faee35dddec7133aee7eca2a352b
https://pubmed.ncbi.nlm.nih.gov/26395516

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Phenolic compounds from the bark of Oroxylum indicum activate the Ngn2 promoter

Autor: Midori A. Arai, Rolly G. Fuentes, Samir Kumar Sadhu, Firoj Ahmed, Masami Ishibashi

Publikováno v: Journal of natural medicines. 69(4)

A reporter gene assay that detects neurogenin 2 (Ngn2) promoter activity was utilized to identify compounds that induce neuronal differentiation. Ngn2 is a basic helix-loop-helix transcription factor that activates transcription of pro-neural genes.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c122ca01354356032418bc25c2a9e84
https://pubmed.ncbi.nlm.nih.gov/26014045

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