Generation, purification and transplantation of photoreceptors derived from human induced pluripotent stem cells.

Autor: Deepak A Lamba, Andrew McUsic, Roli K Hirata, Pei-Rong Wang, David Russell, Thomas A Reh

Publikováno v: PLoS ONE, Vol 5, Iss 1, p e8763 (2010)

BackgroundInherited and acquired retinal degenerations are frequent causes of visual impairment and photoreceptor cell replacement therapy may restore visual function to these individuals. To provide a source of new retinal neurons for cell based the

Externí odkaz: https://doaj.org/article/985078a234eb4cbcaeac81201ba8f71b

HLA-E-expressing pluripotent stem cells escape allogeneic responses and lysis by NK cells

Autor: David W. Russell, Laila-Aicha Hanafi, Dennis O. Clegg, Donna Prunkard, Laura Riolobos, Germán G. Gornalusse, Roli K. Hirata, Sarah E. Funk, Gabriel Manske, Cameron J. Turtle, Aric Colunga, Vanda S Lopes

Publikováno v: Gornalusse, GG; Hirata, RK; Funk, SE; Riolobos, L; Lopes, VS; Manske, G; et al.(2017). HLA-E-expressing pluripotent stem cells escape allogeneic responses and lysis by NK cells. NATURE BIOTECHNOLOGY, 35(8), 765-772. doi: 10.1038/nbt.3860. UC Santa Barbara: Retrieved from: http://www.escholarship.org/uc/item/9s47r57f
Nature biotechnology, vol 35, iss 8
Nature biotechnology

Polymorphisms in the human leukocyte antigen (HLA) class I genes can cause the rejection of pluripotent stem cell (PSC)-derived products in allogeneic recipients. Disruption of the Beta-2 Microglobulin (B2M) gene eliminates surface expression of all

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c1fcae1a64c353ae9878f5385a4854c
http://www.escholarship.org/uc/item/9s47r57f

Trisomy Correction in Down Syndrome Induced Pluripotent Stem Cells

Autor: Pei Rong Wang, Thalia Papayannopoulou, Kai Hsin Chang, Roli K. Hirata, Li B. Li, David W. Russell

Publikováno v: Cell Stem Cell. 11(5):615-619

SummaryHuman trisomies can alter cellular phenotypes and produce congenital abnormalities such as Down syndrome (DS). Here we have generated induced pluripotent stem cells (iPSCs) from DS fibroblasts and introduced a TKNEO transgene into one copy of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bdd3e14f8c3a15d51c7325d86c35a9b1

Isoform- and cell cycle–dependent substrate degradation by the Fbw7 ubiquitin ligase

Autor: Harry C. Hwang, David W. Russell, Michael P. Gustafson, Roli K. Hirata, Amanda Hagar, Markus Welcker, Bruce E. Clurman, Jherek Swanger, Jonathan E. Grim, Johan Ericsson

Publikováno v: The Journal of Cell Biology

The SCFFBW7 ubiquitin ligase degrades proteins involved in cell division, growth, and differentiation and is commonly mutated in cancers. The Fbw7 locus encodes three protein isoforms that occupy distinct subcellular localizations, suggesting that ea

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d913b092b30c1701d96f3eac0223f5c
https://doi.org/10.1083/jcb.200802076

Transduction of Human Embryonic Stem Cells by Foamy Virus Vectors

Autor: James M. Allen, Pei-Rong Wang, Erik M. Olson, Robert E. Richard, David W. Russell, Helen Gharwan, Linlin Wang, Carol B. Ware, Roli K. Hirata

Publikováno v: Molecular Therapy. 15(10):1827-1833

Human embryonic stem cells (hESCs) are important tools for the study of stem cell biology and may ultimately be used in cellular therapies and regenerative medicine. For hESCs to achieve their potential, stable genetic modification of the hESC genome

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35f239b9a6da7859d1e73f4fc2e5d3a3