Systems analysis of transcription factor activities in environments with stable and dynamic oxygen concentrations

Autor: Rolfe, MD, Ocone, A, Stapleton, MR, Hall, S, Trotter, EW, Poole, RK, Sanguinetti, G, Green, J, SysMO-SUMO consortium

Publikováno v: Open Biology, 2(7), 120091. (2012).

Understanding gene regulation requires knowledge of changes in transcription factor (TF) activities. Simultaneous direct measurement of numerous TF activities is currently impossible. Nevertheless, statistical approaches to infer TF activities have y

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______2658::ff19c41e01181739b93866c972caaf94
http://orbilu.uni.lu/handle/10993/4546

The Di-Iron Protein YtfE Is a Nitric Oxide-Generating Nitrite Reductase Involved in the Management of Nitrosative Stress.

Autor: Crack JC; Centre for Molecular and Structural Biochemistry, School of Chemistry, University of East Anglia, Norwich Research Park, Norwich NR4 7TJ, UK., Balasiny BK; Institute of Microbiology and Infection and School of Biosciences, University of Birmingham, Birmingham B15 2TT, UK., Bennett SP; Centre for Molecular and Structural Biochemistry, School of Chemistry, University of East Anglia, Norwich Research Park, Norwich NR4 7TJ, UK., Rolfe MD; School of Biosciences, University of Sheffield, Sheffield S10 2TN, UK., Froes A; Centre for Molecular and Structural Biochemistry, School of Chemistry, University of East Anglia, Norwich Research Park, Norwich NR4 7TJ, UK., MacMillan F; Centre for Molecular and Structural Biochemistry, School of Chemistry, University of East Anglia, Norwich Research Park, Norwich NR4 7TJ, UK., Green J; School of Biosciences, University of Sheffield, Sheffield S10 2TN, UK., Cole JA; Institute of Microbiology and Infection and School of Biosciences, University of Birmingham, Birmingham B15 2TT, UK., Le Brun NE; Centre for Molecular and Structural Biochemistry, School of Chemistry, University of East Anglia, Norwich Research Park, Norwich NR4 7TJ, UK.

Publikováno v: Journal of the American Chemical Society [J Am Chem Soc] 2022 Apr 27; Vol. 144 (16), pp. 7129-7145. Date of Electronic Publication: 2022 Apr 13.

Release of nitric oxide by the Escherichia coli YtfE (RIC) protein and its reduction by the hybrid cluster protein in an integrated pathway to minimize cytoplasmic nitrosative stress.

Autor: Balasiny B; Institute of Microbiology and Infection and School of Biosciences, University of Birmingham, Birmingham B15 2TT, UK., Rolfe MD; Department of Molecular Biology and Biotechnology, University of Sheffield, Sheffield, S10 2TN, UK., Vine C; Institute of Microbiology and Infection and School of Biosciences, University of Birmingham, Birmingham B15 2TT, UK., Bradley C; Institute of Microbiology and Infection and School of Biosciences, University of Birmingham, Birmingham B15 2TT, UK., Green J; Department of Molecular Biology and Biotechnology, University of Sheffield, Sheffield, S10 2TN, UK., Cole J; Institute of Microbiology and Infection and School of Biosciences, University of Birmingham, Birmingham B15 2TT, UK.

Publikováno v: Microbiology (Reading, England) [Microbiology (Reading)] 2018 Apr; Vol. 164 (4), pp. 563-575. Date of Electronic Publication: 2018 Mar 01.

Cmr is a redox-responsive regulator of DosR that contributes to M. tuberculosis virulence.

Autor: Smith LJ; Molecular Biology and Biotechnology, University of Sheffield, Sheffield S10 2TN, UK.; School of Pharmacy, De Montfort University, Leicester LE1 9BH, UK., Bochkareva A; Molecular Biology and Biotechnology, University of Sheffield, Sheffield S10 2TN, UK., Rolfe MD; Molecular Biology and Biotechnology, University of Sheffield, Sheffield S10 2TN, UK., Hunt DM; Division of Mycobacterial Research, MRC National Institute for Medical Research, Mill Hill, London NW7 1AA, UK., Kahramanoglou C; Division of Mycobacterial Research, MRC National Institute for Medical Research, Mill Hill, London NW7 1AA, UK., Braun Y; Division of Mycobacterial Research, MRC National Institute for Medical Research, Mill Hill, London NW7 1AA, UK., Rodgers A; Division of Mycobacterial Research, MRC National Institute for Medical Research, Mill Hill, London NW7 1AA, UK., Blockley A; Division of Mycobacterial Research, MRC National Institute for Medical Research, Mill Hill, London NW7 1AA, UK., Coade S; Division of Mycobacterial Research, MRC National Institute for Medical Research, Mill Hill, London NW7 1AA, UK., Lougheed KEA; Division of Mycobacterial Research, MRC National Institute for Medical Research, Mill Hill, London NW7 1AA, UK., Hafneh NA; Department of Infection, Immunity and Inflammation, University of Leicester, University Road, Leicester LE1 9HN, UK., Glenn SM; Department of Infection, Immunity and Inflammation, University of Leicester, University Road, Leicester LE1 9HN, UK., Crack JC; Centre for Molecular and Structural Biochemistry, School of Chemistry, University of East Anglia, Norwich NR4 7TJ, UK., Le Brun NE; Centre for Molecular and Structural Biochemistry, School of Chemistry, University of East Anglia, Norwich NR4 7TJ, UK., Saldanha JW; Division of Mathematical Biology, MRC National Institute for Medical Research, Mill Hill, London NW7 1AA, UK., Makarov V; A.N. Bach Institute of Biochemistry, Russian Academy of Sciences, Moscow, Russia., Nobeli I; Institute of Structural and Molecular Biology, Department of Biological Sciences, Birkbeck, University of London, Malet Street, London WC1E 7HX, UK., Arnvig K; Institute for Structural and Molecular Biology, University College London, London WC1E 6BT, UK., Mukamolova GV; Department of Infection, Immunity and Inflammation, University of Leicester, University Road, Leicester LE1 9HN, UK., Buxton RS; Division of Mycobacterial Research, MRC National Institute for Medical Research, Mill Hill, London NW7 1AA, UK., Green J; Molecular Biology and Biotechnology, University of Sheffield, Sheffield S10 2TN, UK.

Publikováno v: Nucleic acids research [Nucleic Acids Res] 2017 Jun 20; Vol. 45 (11), pp. 6600-6612.

The mechanism of a formaldehyde-sensing transcriptional regulator.

Autor: Denby KJ; Department of Molecular Biology and Biotechnology, University of Sheffield, Sheffield, S10 2TN, UK., Iwig J; Department of Biochemistry and Molecular Biophysics, Washington University School of Medicine in St. Louis, St. Louis, MO, 63110, USA., Bisson C; Department of Molecular Biology and Biotechnology, University of Sheffield, Sheffield, S10 2TN, UK., Westwood J; Department of Molecular Biology and Biotechnology, University of Sheffield, Sheffield, S10 2TN, UK., Rolfe MD; Department of Molecular Biology and Biotechnology, University of Sheffield, Sheffield, S10 2TN, UK., Sedelnikova SE; Department of Molecular Biology and Biotechnology, University of Sheffield, Sheffield, S10 2TN, UK., Higgins K; Department of Chemistry, University of Massachusetts-Amherst, Amherst, MA 01003, USA., Maroney MJ; Department of Chemistry, University of Massachusetts-Amherst, Amherst, MA 01003, USA., Baker PJ; Department of Molecular Biology and Biotechnology, University of Sheffield, Sheffield, S10 2TN, UK., Chivers PT; Department of Biochemistry and Molecular Biophysics, Washington University School of Medicine in St. Louis, St. Louis, MO, 63110, USA.; Departments of Biosciences and Chemistry, Durham University, Durham, DH1 3LE, UK., Green J; Department of Molecular Biology and Biotechnology, University of Sheffield, Sheffield, S10 2TN, UK.

Publikováno v: Scientific reports [Sci Rep] 2016 Dec 09; Vol. 6, pp. 38879. Date of Electronic Publication: 2016 Dec 09.