Zobrazeno 1 - 10
of 117
pro vyhledávání: '"Rolf Warta"'
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 17, p 9631 (2024)
Meningiomas are the most common primary intracranial tumors in adults and typically have a slow-growing and benign nature. However, there is also a substantial subset of meningiomas that shows aggressive clinical behavior and is refractory to standar
Externí odkaz:
https://doaj.org/article/8f442d5c22dc4bd89e328b2316e0ecfc
Publikováno v:
Cells, Vol 12, Iss 8, p 1200 (2023)
Patients diagnosed with isocitrate dehydrogenase mutant (IDHmut) gliomas suffer frequently from seizures. Although the clinical course is less aggressive than that of its IDH wildtype counterpart, recent discoveries have shown that epileptic activity
Externí odkaz:
https://doaj.org/article/b7ae6e8d0ab64147a3c7441a4caa4f78
Autor:
Gerhard Jungwirth, Rolf Warta, Christopher Beynon, Felix Sahm, Andreas von Deimling, Andreas Unterberg, Christel Herold-Mende, Christine Jungk
Publikováno v:
Acta Neuropathologica Communications, Vol 7, Iss 1, Pp 1-11 (2019)
Abstract Intraventricular meningiomas (IVMs) account for less than 5% of all intracranial meningiomas; hence their molecular phenotype remains unknown. In this study, we were interested whether genetic alterations in IVMs differ from meningiomas in o
Externí odkaz:
https://doaj.org/article/08730fcc1628464c9b2f7a8fda01e919
Autor:
Elena Schnabel, Maximilian Knoll, Christian Schwager, Rolf Warta, Andreas Mock, Benito Campos, Laila König, Christine Jungk, Wolfgang Wick, Andreas Unterberg, Jürgen Debus, Christel Herold-Mende, Amir Abdollahi
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 6, p 2960 (2021)
MicroRNAs (miRs) are non-coding master regulators of transcriptome that could act as tumor suppressors (TSs) or oncogenes (oncomiRs). We aimed to systematically investigate the relevance of miRs as prognostic biomarkers in primary glioblastoma multif
Externí odkaz:
https://doaj.org/article/c6a6a63defb74fd89eaf8ccc7ea640b7
Autor:
Anastasia Makarevic, Carmen Rapp, Steffen Dettling, David Reuss, Christine Jungk, Amir Abdollahi, Andreas von Deimling, Andreas Unterberg, Christel Herold-Mende, Rolf Warta
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 20, p 7801 (2020)
Most gliomas are associated with a fatal prognosis and remain incurable because of their infiltrative growth. Consequently, the addition of immunotherapy to conventional therapy may improve patient outcomes. Here, we analyzed T-cell infiltration and,
Externí odkaz:
https://doaj.org/article/478433af125340fa8fa7294d60545b57
Autor:
Philip Dao Trong, Gerhard Jungwirth, Tao Yu, Stefan Pusch, Andreas Unterberg, Christel Herold-Mende, Rolf Warta
Publikováno v:
Cells, Vol 9, Iss 6, p 1389 (2020)
The discovery of the isocitrate dehydrogenase (IDH) mutation in glioma led to a paradigm shift on how we see glioma biology. Difficulties in cultivating IDH mutant glioma stem cells (IDHmut GSCs) resulted in a paucity of preclinical models in IDHmut
Externí odkaz:
https://doaj.org/article/02fa7134a249469982be048ed9009afc
Autor:
Philip Dao Trong, Saskia Rösch, Heimo Mairbäurl, Stefan Pusch, Andreas Unterberg, Christel Herold-Mende, Rolf Warta
Publikováno v:
International Journal of Molecular Sciences, Vol 19, Iss 10, p 2903 (2018)
Glioma growth is often accompanied by a hypoxic microenvironment favorable for the induction and maintenance of the glioma stem cell (GSC) phenotype. Due to the paucity of cell models of Isocitrate Dehydrogenase 1 mutant (IDH1mut) GSCs, biology under
Externí odkaz:
https://doaj.org/article/bd8c6361598a4a9db1d8d56b6839c774
Autor:
Rolf Warta, Dirk Theile, Carolin Mogler, Esther Herpel, Niels Grabe, Bernd Lahrmann, Peter K Plinkert, Christel Herold-Mende, Johanna Weiss, Gerhard Dyckhoff
Publikováno v:
PLoS ONE, Vol 9, Iss 9, p e108908 (2014)
Drug transporters such as P-glycoprotein (ABCB1) have been associated with chemotherapy resistance and are considered unfavorable prognostic factors for survival of cancer patients. Analyzing mRNA expression levels of a subset of drug transporters by
Externí odkaz:
https://doaj.org/article/26531d2c08dc415ca21d26f8468058ef
Publikováno v:
HNO. 70:595-600
ZusammenfassungKann die primäre Radiochemotherapie (pRCT) möglicherweise als alternative Standardtherapie zur totalen Laryngektomie (TL) angesehen werden? Gemäß der neuen S3-Leitlinie nehme der Patient zwar eine höhere Rückfallrate in Kauf, hab
Publikováno v:
HNO. 70:581-587
Zusammenfassung Hintergrund Derzeit gilt das größere, nicht mehr durch Teilresektionen behandelbare T3-Larynxkarzinom als optimaler Kandidat für einen Larynxorganerhalt (LP) mittels primärer Radiochemotherapie (pRCT). Wann wäre eine primäre Str