Zobrazeno 1 - 10 of 173 pro vyhledávání: '"Rolf W. Winter"'
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Akademický článek
ELQ-331 as a prototype for extremely durable chemoprotection against malaria
Autor: Martin J. Smilkstein, Sovitj Pou, Alina Krollenbrock, Lisa A. Bleyle, Rozalia A. Dodean, Lisa Frueh, David J. Hinrichs, Yuexin Li, Thomas Martinson, Myrna Y. Munar, Rolf W. Winter, Igor Bruzual, Samantha Whiteside, Aaron Nilsen, Dennis R. Koop, Jane X. Kelly, Stefan H. I. Kappe, Brandon K. Wilder, Michael K. Riscoe
Publikováno v: Malaria Journal, Vol 18, Iss 1, Pp 1-17 (2019)
Abstract Background The potential benefits of long-acting injectable chemoprotection (LAI-C) against malaria have been recently recognized, prompting a call for suitable candidate drugs to help meet this need. On the basis of its known pharmacodynami
Externí odkaz: https://doaj.org/article/630a94e7fc5a4c469f0ed0eacdad2650
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2
Babesia duncani as a Model Organism to Study the Development, Virulence, and Drug Susceptibility of Intraerythrocytic Parasites In Vitro and In Vivo
Autor: Anasuya C Pal, Isaline Renard, Pallavi Singh, Pratap Vydyam, Joy E Chiu, Sovitj Pou, Rolf W Winter, Rozalia Dodean, Lisa Frueh, Aaron C Nilsen, Michael K Riscoe, J Stone Doggett, Choukri Ben Mamoun
Publikováno v: J Infect Dis
Human babesiosis is a malaria-like illness caused by tick-borne intraerythrocytic Babesia parasites of the Apicomplexa phylum. Whereas several species of Babesia can cause severe disease in humans, the ability to propagate Babesia duncani both in vit
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f2ff06e28568b78b155fdfc0905ced1
https://doi.org/10.1093/infdis/jiac181
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5
Effective Therapy Targeting Cytochrome bc 1 Prevents Babesia Erythrocytic Development and Protects from Lethal Infection
Autor: Pallavi Singh, Michael K. Riscoe, Aaron Nilsen, Choukri Ben Mamoun, Anasuya Chattopadhyay Pal, Isaline Renard, Shalev Gihaz, Pratap Vydyam, Rolf W. Winter, Madelyn Kumar, Sovitj Pou, Rozalia Dodean, Joy E. Chiu, Jose Thekkiniath, J. Stone Doggett, Lisa Frueh
Publikováno v: Antimicrobial Agents and Chemotherapy. 65
An effective strategy to control blood-borne diseases and prevent outbreak recrudescence involves targeting conserved metabolic processes that are essential for pathogen viability. One such target for Plasmodium and Babesia, the infectious agents of
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0a38680e187640c102397cc447f67e5d
https://doi.org/10.1128/aac.00662-21
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6
Effective Therapy Targeting Cytochrome
Autor: Joy E, Chiu, Isaline, Renard, Anasuya C, Pal, Pallavi, Singh, Pratap, Vydyam, Jose, Thekkiniath, Madelyn, Kumar, Shalev, Gihaz, Sovitj, Pou, Rolf W, Winter, Rozalia, Dodean, Lisa, Frueh, Aaron C, Nilsen, Michael K, Riscoe, J Stone, Doggett, Choukri Ben, Mamoun
Publikováno v: Antimicrob Agents Chemother
An effective strategy to control blood-borne diseases and prevent outbreak recrudescence involves targeting conserved metabolic processes that are essential for pathogen viability. One such target for Plasmodium and Babesia, the infectious agents of
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::59391719c9b4ec090cec9b18e33e27e7
https://pubmed.ncbi.nlm.nih.gov/34152821
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8
Endochin-like quinolone-300 and ELQ-316 inhibit Babesia bovis, B. bigemina, B. caballi and Theileria equi
Autor: Carlos E. Suarez, J. Stone Doggett, Aaron Nilsen, Michael K. Riscoe, Rozalia Dodean, Sovitj Pou, Rolf W. Winter, Reginaldo G. Bastos, Marta G. Silva
Publikováno v: Parasites & Vectors, Vol 13, Iss 1, Pp 1-11 (2020)
Parasites & Vectors
Background The most common apicomplexan parasites causing bovine babesiosis are Babesia bovis and B. bigemina, while B. caballi and Theileria equi are responsible for equine piroplasmosis. Treatment and control of these diseases are usually achieved
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d04a3ba5994621185e089d10d042af49
https://doi.org/10.21203/rs.3.rs-58018/v2
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9
Orally Bioavailable Endochin-Like Quinolone Carbonate Ester Prodrug Reduces Toxoplasma gondii Brain Cysts
Autor: Rolf W. Winter, Tracey L. Schultz, Vern B. Carruthers, Aaron Nilsen, Sovitj Pou, Alyssa J. Miller, Michael K. Riscoe, Rozalia Dodean, Lev N. Zakharov, Igor Bruzual, J. Stone Doggett
Publikováno v: Antimicrob Agents Chemother
Toxoplasmosis is a potentially fatal infection for immunocompromised people and the developing fetus. Current medicines for toxoplasmosis have high rates of adverse effects that interfere with therapeutic and prophylactic regimens. Endochin-like quin
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73e4e76a1889fea9d2161ea769f0fe7b
https://europepmc.org/articles/PMC7449172/
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10
Novel Endochin-Like Quinolones Exhibit Potent In Vitro Activity against Plasmodium knowlesi but Do Not Synergize with Proguanil
Autor: Rolf W. Winter, Michael K. Riscoe, Colin J. Sutherland, Maëlle Duffey, Sovitj Pou, Robert W. Moon, Aaron Nilsen, Donelly A. van Schalkwyk
Publikováno v: Antimicrob Agents Chemother
Quinolones, such as the antimalarial atovaquone, are inhibitors of the malarial mitochondrial cytochrome bc(1) complex, a target critical to the survival of both liver- and blood-stage parasites, making these drugs useful as both prophylaxis and trea
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::97fe40956bda96d40aa7f5ac4f9b85fc
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