Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Rolf Thermann"'
Autor:
Traude H Beilharz, David T Humphreys, Jennifer L Clancy, Rolf Thermann, David I K Martin, Matthias W Hentze, Thomas Preiss
Publikováno v:
PLoS ONE, Vol 4, Iss 8, p e6783 (2009)
Animal microRNAs (miRNAs) typically regulate gene expression by binding to partially complementary target sites in the 3' untranslated region (UTR) of messenger RNA (mRNA) reducing its translation and stability. They also commonly induce shortening o
Externí odkaz:
https://doaj.org/article/83ced30232c94b3c947cf5af2fba3c4b
Autor:
Ingo Schupp, Rolf Thermann, Silke De Zolt, Patrick Unverzagt, Lutz Pichl, Thorsten Bangsow, Christine Jork, Katrin de Rue, Benjamin Müller, Marijke Weber-Schehl, W. Kurt Roth, Doris Hedges
Background: Blood product safety was significantly improved by the introduction of NAT testing in the late 1990s, resulting in a strong decrease of transfusion-transmitted infections (TTIs). Due to the occurrence of HIV-1 NAT test failures as a conse
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a9e56e30e5645f100f65d5949a8dd29
https://europepmc.org/articles/PMC4924456/
https://europepmc.org/articles/PMC4924456/
Publikováno v:
RNA. 16:2493-2502
MicroRNAs (miRs) commonly regulate translation from target mRNA 3′ untranslated regions (UTRs). While effective miR-binding sites have also been identified in 5′ untranslated regions (UTRs) or open reading frames (ORFs), the mechanism(s) of miR-m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::30ae3b1e7dfa1e383c34226dcb714a58
https://doi.org/10.1261/rna.2384610
https://doi.org/10.1261/rna.2384610
Autor:
Matthias W. Hentze, Kent E. Duncan, Rolf Thermann, Thomas Preiss, Edward Darzynkiewicz, Joanna Kowalska, Agnieszka Zdanowicz, Jacek Jemielity
Publikováno v:
Molecular Cell. 35:881-888
Summary Understanding the molecular mechanism(s) of how miRNAs repress mRNA translation is a fundamental challenge in RNA biology. Here we use a validated cell-free system from Drosophila embryos to investigate how miR2 inhibits translation initiatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65098153028530a9d6caa63428882263
https://doi.org/10.1016/j.molcel.2009.09.009
https://doi.org/10.1016/j.molcel.2009.09.009
Publikováno v:
Nucleic Acids Research
BACE1 is the protease responsible for the production of amyloid-beta peptides that accumulate in the brain of Alzheimer's disease (AD) patients. BACE1 expression is regulated at the transcriptional, as well as post-transcriptional level. Very high BA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4153ff72003736178c1e45a793961b8d
https://doi.org/10.1093/nar/gkm191
https://doi.org/10.1093/nar/gkm191
Autor:
Rolf Thermann, Philipp Bruns, Sören Müller, Björn Rotter, Susanne Raulefs, W Kurt Roth, Anna Melissa Schlitter, Carsten Jäger, Klaus Hoffmeier, Fabian J. Theis, Ina Koch, Günter Kahl, Fabian Afonso-Grunz, Bo Kong, Anne Plötner, Peter Winter, Christoph W. Michalski, Ivonne Regel, Jörg Kleeff
Publikováno v:
Mol. Cancer 14:144 (2015)
Molecular Cancer
Molecular Cancer
Previous studies identified microRNAs (miRNAs) and messenger RNAs with significantly different expression between normal pancreas and pancreatic cancer (PDAC) tissues. Due to technological limitations of microarrays and real-time PCR systems these st
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db2ecb2f3f477235a78b9354c2108623
https://doi.org/10.1186/s12943-015-0401-6
https://doi.org/10.1186/s12943-015-0401-6
Autor:
Rolf Thermann, Matthias W. Hentze, Ute Frede, Andreas E. Kulozik, Gabriele Neu-Yilik, Sven Danckwardt
Publikováno v:
Blood. 99:1811-1816
Nonsense-mediated mRNA decay (NMD) represents a phylogenetically widely conserved splicing- and translation-dependent mechanism that eliminates transcripts with premature translation stop codons and suppresses the accumulation of C-terminally truncat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0925d31371fa42815532f773aa885b04
https://doi.org/10.1182/blood.v99.5.1811
https://doi.org/10.1182/blood.v99.5.1811
Autor:
Matthias W. Hentze, Andrea Deters, Kristina Wehr, Christian Hagemeier, Gabriele Neu-Yilik, Andreas E. Kulozik, Ute Frede, Rolf Thermann
Publikováno v:
The EMBO Journal. 17:3484-3494
Premature translation termination codons resulting from nonsense or frameshift mutations are common causes of genetic disorders. Complications arising from the synthesis of C-terminally truncated polypeptides can be avoided by 'nonsense-mediated deca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52d3b67aa670a861dae3903109504e2c
https://doi.org/10.1093/emboj/17.12.3484
https://doi.org/10.1093/emboj/17.12.3484
Autor:
Rolf Thermann, Jennifer L. Clancy, Traude H. Beilharz, David T. Humphreys, David I. K. Martin, Thomas Preiss, Matthias W. Hentze
Publikováno v:
PLoS ONE, Vol 4, Iss 8, p e6783 (2009)
PLoS ONE
PLoS ONE
Animal microRNAs (miRNAs) typically regulate gene expression by binding to partially complementary target sites in the 3' untranslated region (UTR) of messenger RNA (mRNA) reducing its translation and stability. They also commonly induce shortening o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c563593660c29a2befcacd07de7e588
https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/19710908/pdf/?tool=EBI
https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/19710908/pdf/?tool=EBI
Autor:
Miriam Bortfeld, Susanne Till, Michael Hothorn, Rolf Thermann, Erwan Lejeune, Daniel Enderle, Matthias W. Hentze, Constanze Heinrich, Andreas G. Ladurner
Publikováno v:
Nature structuralmolecular biology. 14(10)
Argonaute (Ago) proteins mediate silencing of nucleic acid targets by small RNAs. In fission yeast, Ago1, Tas3 and Chp1 assemble into a RITS complex, which silences transcription near centromeres. Here we describe a repetitive motif within Tas3, term
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f942032364d373526b45d5eb07f50d7c
https://pubmed.ncbi.nlm.nih.gov/17891150
https://pubmed.ncbi.nlm.nih.gov/17891150