Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Rolf T. Windh"'
Autor:
Patrick J. Little, Rolf T. Windh, Chihiro Nozaki, Bertrand Le Bourdonnec, Claire Gaveriaux-Ruff, David Reiss, Brigitte L. Kieffer, Roland E. Dolle
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 342:799-807
N,N-diethyl-4-(5-hydroxyspiro[chromene-2,4′-piperidine]-4-yl) benzamide (ADL5859) and N,N-diethyl-3-hydroxy-4-(spiro[chromene-2,4′-piperidine]-4-yl)benzamide (ADL5747) are novel δ-opioid agonists that show good oral bioavailability and analgesic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c60ec9f6754139926596936823663222
https://doi.org/10.1124/jpet.111.188987
https://doi.org/10.1124/jpet.111.188987
Autor:
Guo-Hua Chu, William M. Barker, Rolf T. Windh, Patrick J. Little, Michael J. Derelanko, Bertrand Le Bourdonnec, Michael Koblish, Diane L. DeHaven-Hudkins, Minghua Gu, Thomas M. Graczyk, Daniel D. Wiant, Lara K. Leister, Bernice L. Brogdon, Robert N. DeHaven, Christopher W. Ajello, Steven A. Smith, Serge Belanger, David D. Christ, Paul A. Tuthill, Steve Kutz, Joel A. Cassel, Marina S. Feschenko, Roland E. Dolle
Publikováno v:
Journal of Medicinal Chemistry. 51:5893-5896
Selective delta opioid receptor agonists are promising potential therapeutic agents for the treatment of various types of pain conditions. A spirocyclic derivative was identified as a promising hit through screening. Subsequent lead optimization iden
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::619e8cbfdd85472b2463e048206eebc5
https://doi.org/10.1021/jm8008986
https://doi.org/10.1021/jm8008986
Publikováno v:
Journal of Biological Chemistry. 276:48733-48739
Sphingosine 1-phosphate (S1P) exerts a variety of actions as a second messenger or as an agonist that binds to one or more members of the Edg family of G protein-coupled receptors. By using human embryonic kidney 293 cells, we show that S1P activates
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::97ed9b83341bffe532aed57ace0287da
https://doi.org/10.1074/jbc.m011072200
https://doi.org/10.1074/jbc.m011072200
N-Myristoylation and βγ Play Roles beyond Anchorage in the Palmitoylation of the G Protein αoSubunit
Publikováno v:
Journal of Biological Chemistry. 274:37435-37442
Many of the alpha subunits of heterotrimeric GTP-binding regulatory proteins (G proteins) are palmitoylated, a modification proposed to play a key role in the stable anchorage of the subunits to the plasma membrane. Palmitoylation of alpha subunits f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1e539d660bc242b22916913e9888e9cf
https://doi.org/10.1074/jbc.274.52.37435
https://doi.org/10.1074/jbc.274.52.37435
Publikováno v:
Journal of Biological Chemistry. 274:27351-27358
Sphingosine 1-phosphate (S1P) is one of several bioactive phospholipids that exert profound mitogenic and morphogenic actions. Originally characterized as a second messenger, S1P is now recognized to achieve many of its effects through cell surface,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40f0abd63fe7974e63b352a011b05583
https://doi.org/10.1074/jbc.274.39.27351
https://doi.org/10.1074/jbc.274.39.27351
Autor:
Thomas M. Graczyk, Patrick J. Little, Diane L. DeHaven-Hudkins, William M. Barker, Michael Koblish, Rolf T. Windh, Minghua Gu, Marina S. Feschenko, Joel A. Cassel, Guo-Hua Chu, Daniel D. Wiant, Steve Kutz, Lara Kathryn Leister, Robert N. DeHaven, Serge Belanger, Bertrand Le Bourdonnec, Roland E. Dolle, Bernice L. Brogdon, Steven A. Smith, Tuthill Paul Anson, Michael J. Derelanko, Q. Jean Zhou, Christopher W. Ajello
Publikováno v:
Journal of medicinal chemistry. 52(18)
Selective, nonpeptidic delta opioid receptor agonists have been the subject of great interest as potential novel analgesic agents. The discoveries of BW373U86 (1) and SNC80 (2) contributed to the rapid expansion of research in this field. However, po
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bfc53d00daff04ac1abedc34cfddc85c
https://pubmed.ncbi.nlm.nih.gov/19694468
https://pubmed.ncbi.nlm.nih.gov/19694468
Publikováno v:
The FASEB Journal. 20
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4218502e49368e94c474e220b5284d9e
https://doi.org/10.1096/fasebj.20.4.a251
https://doi.org/10.1096/fasebj.20.4.a251
Publikováno v:
Current Protocols in Pharmacology
This unit describes methods for studying activity at opioid receptor subtypes and the ORL1 receptor using conventional radioligand binding assay methods as well as procedures for quantitating functional activity of these receptors by measuring agonis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f8f2a9aafa4fc13e36778df58d4cab1b
https://doi.org/10.1002/0471141755.ph0104s29
https://doi.org/10.1002/0471141755.ph0104s29
Autor:
Rolf T, Windh, David R, Manning
Publikováno v:
Methods in enzymology. 344
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::fca9a65f92a4f7f764974783a4253276
https://pubmed.ncbi.nlm.nih.gov/11771391
https://pubmed.ncbi.nlm.nih.gov/11771391
