Výsledky vyhledávání - "Rolf P. G. van Heeswijk"

Akademický článek

The Effect of β-Carotene Supplementation on the Pharmacokinetics of Nelfinavir and Its Active Metabolite M8 in HIV-1-infected Patients

Autor: Humayoun Akhtar, Neera Singhal, Isabelle Seguin, Lina DelBalso, Marc Bourbeau, Bobby M. Chauhan, Donald William Cameron, Mohammed-Rachid Boulassel, David M. Burger, Richard G. Lalonde, Nancy L. Sheehan, Rolf P. G. van Heeswijk, Brian C. Foster

Publikováno v: Molecules, Vol 17, Iss 1, Pp 688-702 (2012)

β-Carotene supplements are often taken by individuals living with HIV-1. Contradictory results from in vitro studies suggest that β-carotene may inhibit or induce cytochrome P450 enzymes and transporters. The study objective was to investigate the

Externí odkaz: https://doaj.org/article/0e26c5151f1b4d07ad31b162107f9024

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Bedaquiline in the treatment of multidrug- and extensively drug-resistant tuberculosis

Autor: Alexander S, Pym, Andreas H, Diacon, Shen-Jie, Tang, Francesca, Conradie, Manfred, Danilovits, Charoen, Chuchottaworn, Irina, Vasilyeva, Koen, Andries, Nyasha, Bakare, Tine, De Marez, Myriam, Haxaire-Theeuwes, Nacer, Lounis, Paul, Meyvisch, Ben, Van Baelen, Rolf P G, van Heeswijk, Brian, Dannemann, Xia, Zhang

Publikováno v: European Respiratory Journal. 47:564-574

Bedaquiline, a diarylquinoline, improved cure rates when added to a multidrug-resistant tuberculosis (MDR-TB) treatment regimen in a previous placebo-controlled, phase 2 trial (TMC207-C208; NCT00449644). The current phase 2, multicenter, open-label,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cff1a02d794789f230b1e419e42384b2
https://doi.org/10.1183/13993003.00724-2015

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Lack of an effect of rilpivirine on the pharmacokinetics of ethinylestradiol and norethindrone in healthy volunteers

Autor: Herta Crauwels, Rolf P. G. van Heeswijk, Marita Stevens, Richard M. W. Hoetelmans, Annemie Buelens

Publikováno v: Int. Journal of Clinical Pharmacology and Therapeutics. 52:118-128

Rilpivirine is a human immunodeficiency virus Type 1 (HIV-1) non-nucleoside reverse transcriptase inhibitor. Objective: Rilpivirine metabolism involves cytochrome P450 3A4 (CYP3A4). This trial (ClinicalTrials. gov number: NCT00739622) evaluated the i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7eb58d537ba83a9522a087e99b93f63c
https://doi.org/10.5414/cp201943

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Telaprevir: Pharmacokinetics and Drug Interactions

Autor: Rolf P. G. van Heeswijk, Robert S. Kauffman, Varun Garg, Maria Beaumont

Publikováno v: Antiviral Therapy. 17:1211-1221

Telaprevir is an inhibitor of the HCV NS3/4A protease. When used in combination with pegylated interferon and ribavirin, telaprevir has demonstrated a substantial increase in sustained virological response compared with pegylated interferon and ribav

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df6dc0642abc836533482063d12b82b6
https://doi.org/10.3851/imp2356

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Pharmacokinetics and tolerability of once- versus twice-daily lopinavir/ritonavir treatment in HIV-1-infected children

Autor: Charles la Porte, Rolf P. G. van Heeswijk, Chokechai Rongkavilit, Jackie Parker, Charles D. Mitchell, Guijun Zhang

Publikováno v: Antiviral Therapy. 14:603-606

BackgroundOnce-daily lopinavir/ritonavir (LPV/r) is not approved for treatment of HIV paediatric patients. Once daily treatment in children might serve the same goals of patient comfort and adherence as in adults.MethodsHIV type-1-infected children a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::917c673b5945233f4550d64bb97b8d49
https://doi.org/10.1177/135965350901400408

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Inhibition of adenine nucleotide translocator pore function and protection against apoptosis in vivo by an HIV protease inhibitor

Publikováno v: Journal of Clinical Investigation
Journal of Clinical Investigation, American Society for Clinical Investigation, 2005, 115, pp.1828-1838

Inhibitors of HIV protease have been shown to have antiapoptotic effects in vitro, yet whether these effects are seen in vivo remains controversial. In this study, we have evaluated the impact of the HIV protease inhibitor (PI) nelfinavir, boosted wi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47db10cf4943def6f728cc0681cb874c
https://doi.org/10.1172/jci22954

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Optimized antiretroviral therapy: the role of therapeutic drug monitoring and pharmacogenomics

Autor: Rolf P. G. van Heeswijk

Publikováno v: Expert Review of Anti-infective Therapy. 1:75-81

The identification of relationships between plasma concentrations of protease inhibitors and later, the non-nucleoside reverse transcriptase inhibitors and their efficacy and toxicity has caused a growing interest in the concept of therapeutic drug m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05a329dc7fc9db140d2448d53ec9bb78
https://doi.org/10.1586/14787210.1.1.75

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Pharmacokinetics of Once-Daily Saquinavir Hard-Gelatin Capsules and Saquinavir Soft-Gelatin Capsules Boosted With Ritonavir in HIV-1–Infected Subjects

Autor: David M. Burger, Andrew F. Hill, Peter Cardiello, Joep M. A. Lange, Rolf P. G. van Heeswijk, David A. Cooper, Tarkika Monhaphol, Praphan Phanuphak, Apicha Mahanontharit, Kiat Ruxrungtham

Publikováno v: Journal of acquired immune deficiency syndromes (1999), 32(4), 375-379. Lippincott Williams and Wilkins
JAIDS : Journal of Acquired Immune Deficiency Syndromes, 32, 375-9
JAIDS : Journal of Acquired Immune Deficiency Syndromes, 32, 4, pp. 375-9

Item does not contain fulltext OBJECTIVE: To investigate the pharmacokinetics of once-daily saquinavir (SQV) hard-gelatin capsule (HGC)/ritonavir (RTV), 1600/100 mg, compared with once-daily SQV soft-gelatin capsule (SGC)/RTV, 1600/100 mg. METHODS: W

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03e99d4bf59ae1edf5d6cedd32bbabef
https://doi.org/10.1097/00126334-200304010-00005

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The Pharmacokinetics of Nelfinavir in HIV-1—Infected Children

Autor: Joep M. A. Lange, Rolf P. G. van Heeswijk, T. Linda A. De Koning, Hugo S. A. Heymans, Richard M. W. Hoetelmans, Henriette J. Scherpbier, Jos H. Beijnen

Publikováno v: Therapeutic drug monitoring, 24(4), 487-491. Lippincott Williams and Wilkins

The authors investigated the steady-state plasma pharmacokinetics of nelfinavir in HIV-1-infected children in a dosage of 30 mg/kg every 8 hours and 45 mg/kg every 12 hours in 12 HIV-1-infected children (aged 2.1 to 10.8 years) participating in an op

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::276ee7d5529a9a16d6778df7baddb325
https://doi.org/10.1097/00007691-200208000-00004

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Stable concentrations of zidovudine, stavudine, lamivudine, abacavir, and nevirapine in serum and cerebrospinal fluid during 2 years of therapy

Autor: Jan M. Prins, Rolf P. G. van Heeswijk, Jean-Pierre Sommadossi, Xiao-Jian Zhou, Suzanne Jurriaans, Joep M. A. Lange, Elisabeth C. M. van Weert, Richard M. W. Hoetelmans, Rieneke M. E. van Praag

Publikováno v: Antimicrobial agents and chemotherapy, 46(3), 896-899. American Society for Microbiology

For a number of antiretroviral drugs, prolonged suppression of viral replication is related to drug exposure. Therefore, it is important to maintain stable concentrations during prolonged therapy. While studies suggest that saquinavir concentrations

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1be74e3367529a167e952701856fba39
https://doi.org/10.1128/aac.46.3.896-899.2002

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