Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Rolf Osterwalder"'
Autor:
Björn Wagner, Rolf Osterwalder, Eric A. Ertel, Lucette Doessegger, Icilio Cavero, Marion Aubert, Isabelle Parrilla
Publikováno v:
Drug Safety. 29:237-254
Background: The issue of drug-induced QT interval prolongation and torsades de pointes represents a major concern for pharmaceutical development. In this investigation, we examined the value of the isolated rabbit Purkinje fibre as an in vitro action
Publikováno v:
Journal of Cardiovascular Pharmacology. 34:199-205
Endothelin (ET) may play an important role in the pathogenesis of vasoconstriction and acute renal failure after aortic cross-clamping (ACC). However, the relative contribution of the ET(A) and ET(B) receptors to the physiopathology of ischemic acute
Autor:
Volker Breu, Jean-Paul Maire, Martine Clozel, Bernd-Michael Löffler, Peter Brändli, Rolf Osterwalder
Publikováno v:
Pain. 64:315-322
In addition to their potent vasoconstrictor properties, the endothelins (endothelin-1 and -3) may possess neurotransmitter/neuromediator and neuroendocrine actions. The aim of the present study was to evaluate the role of endothelins (ET) in mediatin
Publikováno v:
Biochemical and Biophysical Research Communications. 186:867-873
It has been suggested that the endothelin (ET) ETB receptor could mediate endothelium-dependent vasodilation to ET-1 or ET-3, but its in vivo role is still largely unknown. We used sarafotoxin S6C, a selective agonist of the ETB receptor, to study th
Autor:
Didier Heudes, Rolf Osterwalder, Changbin Qiu, Jean-Paul Clozel, Patrick Bruneval, Martine Clozel, Andrée Roeckel
Publikováno v:
Journal of cardiovascular pharmacology. 33(4)
This study was set up to evaluate the long-term effects of nonpeptide endothelin (ET) antagonists in rats with renal mass reduction (RMR). In the first series of experiments, rats were administered bosentan (100 mg/kg/day) or the angiotensin-converti
Publikováno v:
Journal of Pharmacological and Toxicological Methods. 56:e5
Autor:
G. Haeusler, Rolf Osterwalder
Publikováno v:
Naunyn-Schmiedeberg's Archives of Pharmacology. 314:111-121
There is evidence that the undecapeptide substance P is the transmitter released from pain fibres in the dorsal horn of the spinal cord. This, in turn, suggested to use the possibility of a similar role for substance P in another type of primary sens