Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Rolf Noreen"'
Autor:
Jimmy Lindberg, Seved Löwgren, Hong Zhang, Torsten Unge, K. Fridborg, Snaevar Sigurdsson, Hans O Andersson, Rolf Noreen, Christer Sahlberg
Publikováno v:
European Journal of Biochemistry. 269:1670-1677
The K103N substitution is a frequently observed HIV-1 RT mutation in patients who do not respond to combination-therapy. The drugs Efavirenz, MSC194 and PNU142721 belong to the recent generation of NNRTIs characterized by an improved resistance profi
Autor:
Johansson Nils Gunnar, F W Bell, Marita Högberg, Rolf Noreen, Jaskunas, C. L. Jordan, Cantrell As, Peter Thomas Lind, J. M. Jun. Morin, Kinnick
Publikováno v:
Journal of Medicinal Chemistry. 38:4929-4936
A novel series of potent specific HIV-1 inhibitory compounds is described. The lead compound in the series, N-(2-phenethyl)-N'-(2-thiazolyl)thiourea (1), inhibits HIV-1 RT using rCdG as the template with an IC50 of 0.9 microM. In MT-4 cells, compound
Publikováno v:
Antiviral Research. 24:43-57
Two mutants of HIV-1 reverse transcriptase (RT), Tyr-188--His and Glu-138--Arg have been prepared and their catalytic properties and sensitivities to inhibitors studied. As compared to wild type RT, a reduction in catalytic efficiency and turn over n
Autor:
Bo Öberg, Peter Thomas Lind, N.-G. Johansson, Christer Sahlberg, Lotta Vrang, C. Lopez, J. Kangasmetä, Björn Classon, Marita Högberg, J. Munroe, Rolf Noreen, Hong Zhang, S. Mauldin, Robert J. Ternansky, J. M. Jun. Morin, P. Engelhardt
Publikováno v:
Antiviral Research. 26:A257
Autor:
S. Mauldin, Christer Sahlberg, C. Rydergåd, Björn Classon, Rolf Noreen, P. Engelhardt, Robert J. Ternansky, N.-G. Johansson, J. Kangasmetsa, Lotta Vrang, Marita Högberg, C. Åhgren, C. Lopez, Bo Öberg, J. M. Jun. Morin, Peter Thomas Lind, J. Munroe
Publikováno v:
Antiviral Research. 26:A236