Zobrazeno 1 - 10
of 104
pro vyhledávání: '"Rolf Jaussi"'
Autor:
Franziska M. Heydenreich, Tamara Miljuš, Rolf Jaussi, Roger Benoit, Dalibor Milić, Dmitry B. Veprintsev
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-11 (2017)
Abstract Site-directed scanning mutagenesis is a powerful protein engineering technique which allows studies of protein functionality at single amino acid resolution and design of stabilized proteins for structural and biophysical work. However, crea
Externí odkaz:
https://doaj.org/article/1b11ce312b1949debc1d11e568ec22af
Autor:
Rajesh Jayachandran, Xiaolong Liu, Somdeb Bosedasgupta, Philipp Müller, Chun-Lei Zhang, Despina Moshous, Vera Studer, Jacques Schneider, Christel Genoud, Catherine Fossoud, Frédéric Gambino, Malik Khelfaoui, Christian Müller, Deborah Bartholdi, Helene Rossez, Michael Stiess, Xander Houbaert, Rolf Jaussi, Daniel Frey, Richard A Kammerer, Xavier Deupi, Jean-Pierre de Villartay, Andreas Lüthi, Yann Humeau, Jean Pieters
Publikováno v:
PLoS Biology, Vol 12, Iss 3, p e1001820 (2014)
Cognitive and behavioral disorders are thought to be a result of neuronal dysfunction, but the underlying molecular defects remain largely unknown. An important signaling pathway involved in the regulation of neuronal function is the cyclic AMP/Prote
Externí odkaz:
https://doaj.org/article/5f217f7498134941886d3e2799f2c271
Autor:
Dawei Sun, Martin K Ostermaier, Franziska M Heydenreich, Daniel Mayer, Rolf Jaussi, Joerg Standfuss, Dmitry B Veprintsev
Publikováno v:
PLoS ONE, Vol 8, Iss 10, p e78878 (2013)
Scanning mutagenesis is a powerful protein engineering technique used to study protein structure-function relationship, map binding sites and design more stable proteins or proteins with altered properties. One of the time-consuming tasks encountered
Externí odkaz:
https://doaj.org/article/d99a3a79b09544b6a7c19f918e916201
Autor:
Saša Bjelić, Mara Wieser, Daniel Frey, Christian U Stirnimann, Mark R Chance, Rolf Jaussi, Michel O Steinmetz, Richard A Kammerer
Publikováno v:
PLoS ONE, Vol 8, Iss 5, p e63370 (2013)
Coiled coils are well suited to drive subunit oligomerization and are widely used in applications ranging from basic research to medicine. The optimization of these applications requires a detailed understanding of the molecular determinants that con
Externí odkaz:
https://doaj.org/article/626cdc7a89c6492abb156952fefd3061
Autor:
Michel O. Steinmetz, Pierre Gönczy, Virginie Hamel, Rolf Jaussi, Isabelle Flückiger, Masafumi Hirono, Sebastian H. W. Kraatz, Sarah Hosner, Daniel Frey, Katherine M. Thieltges, Xavier Deupi, Paul Guichard, Daniel J. Müller, Moritz Pfreundschuh, Akira Noga, Mara M. Wieser, Richard A. Kammerer, Manuel Hilbert
Publikováno v:
Nature Cell Biology
Centrioles are critical for the formation of centrosomes, cilia and flagella in eukaryotes. They are thought to assemble around a nine-fold symmetric cartwheel structure established by SAS-6 proteins. Here, we have engineered Chlamydomonas reinhardti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef82172672d9f69e89f0925b786f2e85
https://doi.org/10.1038/ncb3329
https://doi.org/10.1038/ncb3329
Autor:
Mara M. Wieser, Richard A. Kammerer, Katherine M. Thieltges, Guido Capitani, Roger Benoit, Rolf Jaussi, Daniel Frey
Publikováno v:
Toxicon. 107:25-31
Botulinum neurotoxin A causes botulism but is also used for medical and cosmetic applications. A detailed molecular understanding of BoNT/A--host receptor interactions is therefore fundamental for improving current clinical applications and for devel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35d2b5d3b83a9edb7dfd653a31784790
https://doi.org/10.1016/j.toxicon.2015.08.002
https://doi.org/10.1016/j.toxicon.2015.08.002
Autor:
Rolf Jaussi, Franziska M. Heydenreich, Roger Benoit, Dmitry B. Veprintsev, Dalibor Milić, Tamara Miljuš
Publikováno v:
Scientific Reports
Scientific Reports, 7
Scientific Reports, Vol 7, Iss 1, Pp 1-11 (2017)
Scientific Reports, 7
Scientific Reports, Vol 7, Iss 1, Pp 1-11 (2017)
Site-directed scanning mutagenesis is a powerful protein engineering technique which allows studies of protein functionality at single amino acid resolution and design of stabilized proteins for structural and biophysical work. However, creating libr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ff4d55e244512997dd7124ac5d932f1
http://europepmc.org/articles/PMC5533798
http://europepmc.org/articles/PMC5533798
Publikováno v:
PNAS
Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America
Arrestins function as adapter proteins that mediate G protein-coupled receptor (GPCR) desensitization, internalization, and additional rounds of signaling. Here we have compared binding of the GPCR rhodopsin to 403 mutants of arrestin-1 covering its
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::206126a8679ad692dfe14b4ec652744b
Autor:
Thomas R. Ward, Thomas Schleier, Rolf Jaussi, Kurt Ballmer-Hofer, Marc Dürrenberger, Elisa S. Nogueira
Publikováno v:
Protein expression and purification
Artificial metalloenzymes result from the incorporation of a catalytically competent biotinylated organometallic moiety into full-length ( i.e. mature) streptavidin. With large-scale industrial biotechnology applications in mind, large quantities of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04f4d898205cd52127dae958202adba7
https://doi.org/10.1016/j.pep.2013.10.015
https://doi.org/10.1016/j.pep.2013.10.015
Autor:
Richard A. Kammerer, Svetlana V. Selivanova, Selena Milicevic Sephton, Rolf Jaussi, Jason P. Holland, Mara M. Wieser, Albert Kang, Roger Schibli, Susan Cohrs, Daniel Frey, Eliane Fischer, Thomas Betzel
Publikováno v:
Chemistry & Biodiversity. 10:538-555
Kinesin spindle protein (KSP), an ATP-dependent motor protein, plays an essential role in bipolar spindle formation during the mitotic phase (M phase) of the normal cell cycle. KSP has emerged as a novel target for antimitotic anticancer drug develop
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::84679a56a50844ee1808d85cad2a9d54
https://doi.org/10.1002/cbdv.201200400
https://doi.org/10.1002/cbdv.201200400