Zobrazeno 1 - 10
of 218
pro vyhledávání: '"Rolf Jansen"'
Autor:
Katharina Rox, Rolf Jansen, Tadeja Lukežič, Marina Greweling-Pils, Jennifer Herrmann, Marcus Miethke, Stephan Hüttel, Fabienne Hennessen, Antoine Abou Fayad, Cornelia Holzhausen, Carina Vingsbo Lundberg, Joanne Teague, Enge Sudarman, Lisa Bülter, Thomas Hesterkamp, Marc Stadler, Mark Brönstrup, Rolf Müller
Publikováno v:
Microbiology Spectrum, Vol 12, Iss 1 (2024)
ABSTRACT The quest for novel anti-infectives against drug-resistant pathogens of the so-called ESKAPE panel is accompanied by intensive research aiming to find treatment options for the future. In this study, we evaluated the pharmacokinetics and pha
Externí odkaz:
https://doaj.org/article/820d30d4e9e141c286291b4710977660
Autor:
Yunsheng Gao, Joy Birkelbach, Chengzhang Fu, Jennifer Herrmann, Herbert Irschik, Bernd Morgenstern, Kerstin Hirschfelder, Ruijuan Li, Youming Zhang, Rolf Jansen, Rolf Müller
Publikováno v:
Microbiology Spectrum, Vol 11, Iss 4 (2023)
ABSTRACT Myxobacteria serve as a treasure trove of secondary metabolites. During our ongoing search for bioactive natural products, a novel subclass of disorazoles termed disorazole Z was discovered. Ten disorazole Z family members were purified from
Externí odkaz:
https://doaj.org/article/a9bcc911fd694cd29d1fbf1aa2184424
Autor:
Katharina Rox, Tim Becker, Andrea Schiefer, Miriam Grosse, Alexandra Ehrens, Rolf Jansen, Tilman Aden, Stefan Kehraus, Gabriele M. König, Anna K. Krome, Marc P. Hübner, Karl G. Wagner, Marc Stadler, Kenneth Pfarr, Achim Hoerauf
Publikováno v:
Pharmaceutics, Vol 15, Iss 1, p 131 (2022)
Methicillin-resistant Staphylococcus aureus (MRSA) is a World Health Organization’s high priority pathogen organism, with an estimated > 100,000 deaths worldwide in 2019. Thus, there is an unmet medical need for novel and resistance-breaking anti-i
Externí odkaz:
https://doaj.org/article/edb4852a2b3245799a4221b686948f81
Autor:
Tim Becker, Anna K. Krome, Sahel Vahdati, Andrea Schiefer, Kenneth Pfarr, Alexandra Ehrens, Tilman Aden, Miriam Grosse, Rolf Jansen, Silke Alt, Thomas Hesterkamp, Marc Stadler, Marc P. Hübner, Stefan Kehraus, Gabriele M. König, Achim Hoerauf, Karl G. Wagner
Publikováno v:
Pharmaceutics, Vol 14, Iss 8, p 1657 (2022)
In vivo studies in mice provide a valuable model to test novel active pharmaceutical ingredients due to their low material need and the fact that mice are frequently used as a species for early efficacy models. However, preclinical in vitro evaluatio
Externí odkaz:
https://doaj.org/article/d722c35fa6af4f79a653c16ff534728b
Autor:
Jan Balansky, Kenneth Pfarr, Christiane Szekat, Stefan Kehraus, Tilman Aden, Miriam Grosse, Rolf Jansen, Thomas Hesterkamp, Andrea Schiefer, Gabriele M. König, Marc Stadler, Achim Hoerauf, Gabriele Bierbaum
Publikováno v:
Antibiotics, Vol 11, Iss 7, p 920 (2022)
Corallopyronin A (CorA) is active against Gram-positive bacteria and targets the switch region of RNA polymerase. Because of the high frequency of mutation (FoM) leading to rifampicin resistance, we determined the CorA FoM in S. aureus using fluctuat
Externí odkaz:
https://doaj.org/article/f755728120db4450ac61d370364e0082
Autor:
Andrea Schiefer, Marc P Hübner, Anna Krome, Christine Lämmer, Alexandra Ehrens, Tilman Aden, Marianne Koschel, Helene Neufeld, Lillibeth Chaverra-Muñoz, Rolf Jansen, Stefan Kehraus, Gabriele M König, Domen Pogorevc, Rolf Müller, Marc Stadler, Stephan Hüttel, Thomas Hesterkamp, Karl Wagner, Kenneth Pfarr, Achim Hoerauf
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 14, Iss 12, p e0008930 (2020)
Current efforts to eliminate the neglected tropical diseases onchocerciasis and lymphatic filariasis, caused by the filarial nematodes Onchocerca volvulus and Wuchereria bancrofti or Brugia spp., respectively, are hampered by lack of a short-course m
Externí odkaz:
https://doaj.org/article/d4370a71cad149209e66761eb918df85
Autor:
Lucky S. Mulwa, Rolf Jansen, Dimas F. Praditya, Kathrin I. Mohr, Patrick W. Okanya, Joachim Wink, Eike Steinmann, Marc Stadler
Publikováno v:
Beilstein Journal of Organic Chemistry, Vol 14, Iss 1, Pp 1554-1562 (2018)
Lanyamycin (1/2), a secondary metabolite occurring as two epimers, was isolated from the myxobacterium Sorangium cellulosum, strain Soce 481. The structures of both epimers were elucidated from HRESIMS and 1D and 2D NMR data and the relative configur
Externí odkaz:
https://doaj.org/article/4bcf0dfe4308475d95a6525eef156f4e
Autor:
Grégory Menchon, Andrea E. Prota, Daniel Lucena-Agell, Pascal Bucher, Rolf Jansen, Herbert Irschik, Rolf Müller, Ian Paterson, J. Fernando Díaz, Karl-Heinz Altmann, Michel O. Steinmetz
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-9 (2018)
Microtubule-targeting agents are used successfully as anticancer therapeutics. Here authors develop a fluorescence-anisotropy-based assay to identify and characterize ligands for the maytansine site of tubulin and provide crystal structures of identi
Externí odkaz:
https://doaj.org/article/0ff5964567e04f11ab1504ca1c9d29cf
Autor:
Thomas Hoffmann, Daniel Krug, Nisa Bozkurt, Srikanth Duddela, Rolf Jansen, Ronald Garcia, Klaus Gerth, Heinrich Steinmetz, Rolf Müller
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-10 (2018)
It is thought that the chances for discovery of novel natural products increase by screening rare organisms. Here the authors analyse metabolites produced by over 2300 myxobacterial strains and, indeed, find a correlation between taxonomic distance a
Externí odkaz:
https://doaj.org/article/e04d0d9067134cffaac70fff45d6321e
Autor:
Anna K. Krome, Tim Becker, Stefan Kehraus, Andrea Schiefer, Christian Steinebach, Tilman Aden, Stefan J. Frohberger, Álvaro López Mármol, Dnyaneshwar Kapote, Rolf Jansen, Lillibeth Chaverra-Muñoz, Marc P. Hübner, Kenneth Pfarr, Thomas Hesterkamp, Marc Stadler, Michael Gütschow, Gabriele M. König, Achim Hoerauf, Karl G. Wagner
Publikováno v:
Pharmaceutics, Vol 12, Iss 11, p 1105 (2020)
Novel-antibiotics are urgently needed to combat an increase in morbidity and mortality due to resistant bacteria. The preclinical candidate corallopyronin A (CorA) is a potent antibiotic against Gram-positive and some Gram-negative pathogens for whic
Externí odkaz:
https://doaj.org/article/e03acd88b74a4c9d8c536584505e42ed