Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Rolf I. Carlson"'
Autor:
Yoshifumi Iwagami, Sarah Casulli, Katsuya Nagaoka, Miran Kim, Rolf I. Carlson, Kosuke Ogawa, Michael S. Lebowitz, Steve Fuller, Biswajit Biswas, Solomon Stewart, Xiaoqun Dong, Hossein Ghanbari, Jack R. Wands
Publikováno v:
Heliyon, Vol 3, Iss 9 (2017)
Background and aims: Hepatocellular carcinoma (HCC) is a difficult to treat tumor with a poor prognosis. Aspartate β-hydroxylase (ASPH) is a highly conserved enzyme overexpressed on the cell surface of both murine and human HCC cells. Methods: We ev
Externí odkaz:
https://doaj.org/article/a8d450ab73fd4cff99ad7eeec69711d0
Autor:
Sarah M. DeNucci, Ming Tong, Lisa Longato, Margot Lawton, Mashiko Setshedi, Rolf I. Carlson, Jack R. Wands, Suzanne M. de la Monte
Publikováno v:
Gastroenterology Research and Practice, Vol 2010 (2010)
The finding of more severe steatohepatitis in alcohol fed Long Evans (LE) compared with Sprague Dawley (SD) and Fisher 344 (FS) rats prompted us to determine whether host factors related to alcohol metabolism, inflammation, and insulin/IGF signaling
Externí odkaz:
https://doaj.org/article/06123ee00d704a0ab44ed004aec96910
Autor:
Xuewei Bai, Xiaoqun Dong, Nader Maarouf, Hossein A. Ghanbari, Hikaru Hayashi, Bo Zhai, Rolf I. Carlson, Songhua Zhang, Jack R. Wands, Aryanna Sousa, Yoshihiro Matsumoto, Yuki Yokota, Yanmei Zhou, Bei Sun
Background Interactions between tumor and microenvironment determine individual response to immunotherapy. Triple negative breast cancer (TNBC) and hepatocellular carcinoma (HCC) have exhibited suboptimal responses to immune checkpoint inhibitors (IC
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1dfdb5e933a8b019dc392a22ce22ef33
https://doi.org/10.21203/rs.3.rs-966722/v1
https://doi.org/10.21203/rs.3.rs-966722/v1
Autor:
Xuewei, Bai, Yanmei, Zhou, Qiushi, Lin, Chiung-Kuei, Huang, Songhua, Zhang, Rolf I, Carlson, Hossein, Ghanbari, Bei, Sun, Jack R, Wands, Xiaoqun, Dong
Publikováno v:
Am J Cancer Res
Triple negative breast cancer (TNBC) is more aggressive and has a poorer prognosis than other sub-types of breast tumors. This study elucidates how aspartate beta-hydroxylase (ASPH) network promotes drug resistance, and immunotherapy targeting ASPH m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::a2fcc1758c82c7a8216f91d164812a04
https://europepmc.org/articles/PMC8493397/
https://europepmc.org/articles/PMC8493397/
Autor:
Kevin P. Charpentier, Qiushi Lin, Hua Chen, Hong Zhu, Kosuke Ogawa, Songhua Zhang, Lianxin Liu, Min Li, Yongwei Wang, Le Li, Bei Sun, Katsuya Nagaoka, Howard Safran, Qinggang Xu, Rolf I. Carlson, Jack R. Wands, Xuesong Chen, Rui Kong, Fuliang He, Xiaoqun Dong, Xuewei Bai
Publikováno v:
Cancer Lett
To demonstrate multifaceted contribution of aspartate β-hydroxylase (ASPH) to pancreatic ductal adenocarcinoma (PDAC) pathogenesis, in vitro metastasis assay and patient derived xenograft (PDX) murine models were established. ASPH propagates aggress
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17c8f0d6d5cae119be02463b818218a7
https://europepmc.org/articles/PMC7309190/
https://europepmc.org/articles/PMC7309190/
Autor:
Kevin P. Charpentier, Qiushi Lin, Howard Safran, Kosuke Ogawa, Lianxin Liu, Fuliang He, Yongwei Wang, Bei Sun, Rui Kong, Songhua Zhang, Katsuya Nagaoka, Hong Zhu, Qinggang Xu, Hua Chen, Jack R. Wands, Rolf I. Carlson, Le Li, Xuesong Chen, Xuewei Bai, Xiaoqun Dong, Min Li
Publikováno v:
Journal of Hematology & Oncology
Journal of Hematology & Oncology, Vol 12, Iss 1, Pp 1-16 (2019)
Journal of Hematology & Oncology, Vol 12, Iss 1, Pp 1-16 (2019)
BackgroundSignaling pathways critical for embryonic development re-emerge in adult pancreas during tumorigenesis. Aspartate β-hydroxylase (ASPH) drives embryonic cell motility/invasion in pancreatic development/differentiation. We explored if dysreg
Autor:
Jack A. Elias, Ghun Geun Lee, Chang-Min Lee, Rolf I. Carlson, Rishubh Jain, Aryanna Sousa, Jack R. Wands, Mengqui Lin, Bing Ma, Jin Wook Park, Suchitra Kamle, Ayako Iwano, Songhua Zhang
Publikováno v:
Cells
Cells, Vol 10, Iss 201, p 201 (2021)
Volume 10
Issue 2
Cells, Vol 10, Iss 201, p 201 (2021)
Volume 10
Issue 2
A recently discovered human glycoprotein, chitinase 3-like 1 (Chi3L1), may play a role in inflammation, tissue remodeling, and visceral fat accumulation. We hypothesize that Chi3L1 gene expression is important in the development of hepatic insulin re
Autor:
Hironori Koga, Miran Kim, Jing Zou, Jack R. Wands, Rolf I. Carlson, Chiung-Kuei Huang, Arihiro Aihara, Tunan Yu, Yoshifumi Iwagami, Sarah Casulli
Publikováno v:
Cancer Letters. 380:153-162
Background and aims The role of transforming growth factor beta 1 (TGFβ1) in cholangiocarcinoma (CCA) initiation and growth requires further definition. Methods We employed pharmacological and genetic approaches to inhibit or enhance TGFβ1 signalin
Autor:
Chiung-Kuei Huang, Xiaoqun Dong, Yoshifumi Iwagami, Qiushi Lin, Grace Jang, Jack R. Wands, Miran Kim, Carl E. Wagner, Mark Olsen, Rolf I. Carlson, John Michael Thomas
Publikováno v:
Hepatology. 63:1213-1226
Aspartate β-hydroxylase (ASPH) is an enzyme overexpressed in human hepatocellular carcinoma (HCC) tumors that participates in the malignant transformation process. We determined if ASPH was a therapeutic target by exerting effects on cellular senesc
Autor:
Songhua Zhang, Jack R. Wands, Steve Fuller, Zhi-Gang Jiang, Katsuya Nagaoka, Xuewei Bai, Kosuke Ogawa, Rolf I. Carlson, Hossein A. Ghanbari, Yanmei Zhou, Xiaoqun Dong, Michael S. Lebowitz
Publikováno v:
Cancer Lett
Pancreatic ductal adenocarcinoma (PDAC) is an extremely aggressive malignancy with very limited treatment options. Antibody drug conjugates (ADCs) are promising cytotoxic agents capable of highly selective delivery. Aspartate-β-hydroxylase (ASPH) is