Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Rolf Heuman"'
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 5, p 3030 (2024)
The small GTPase RAS acts as a plasma membrane-anchored intracellular neurotrophin counteracting neuronal degeneration in the brain, but the underlying molecular mechanisms are largely unknown. In transgenic mice expressing constitutively activated V
Externí odkaz:
https://doaj.org/article/ba4aeee145ed4da7819dca18dc1c24e4
Autor:
Fabian Raudzus, Hendrik Schöneborn, Sebastian Neumann, Emilie Secret, Aude Michel, Jérome Fresnais, Oliver Brylski, Christine Ménager, Jean-Michel Siaugue, Rolf Heumann
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-15 (2020)
Abstract The axon regeneration of neurons in the brain can be enhanced by activating intracellular signaling pathways such as those triggered by the membrane-anchored Rat sarcoma (RAS) proto-oncogene. Here we demonstrate the induction of neurite grow
Externí odkaz:
https://doaj.org/article/469834a1376b4864b8dbf490c4de69c9
Autor:
Markus Dicks, Gerd Kock, Bastian Kohl, Xueyin Zhong, Stefanie Pütz, Rolf Heumann, Kai S. Erdmann, Raphael Stoll
Publikováno v:
BMC Molecular and Cell Biology, Vol 20, Iss 1, Pp 1-12 (2019)
Abstract Background Protein tyrosine phosphatase PTPN13, also known as PTP-BL in mice, is a large multi-domain non-transmembrane scaffolding protein with a molecular mass of 270 kDa. It is involved in the regulation of several cellular processes such
Externí odkaz:
https://doaj.org/article/5b2a6bcbda254ecda2ff7021a1941f83
Autor:
Maud Bongaerts, Koceila Aizel, Emilie Secret, Audric Jan, Tasmin Nahar, Fabian Raudzus, Sebastian Neumann, Neil Telling, Rolf Heumann, Jean-Michel Siaugue, Christine Ménager, Jérôme Fresnais, Catherine Villard, Alicia El Haj, Jacob Piehler, Monte A. Gates, Mathieu Coppey
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 18, p 6560 (2020)
The remote actuation of cellular processes such as migration or neuronal outgrowth is a challenge for future therapeutic applications in regenerative medicine. Among the different methods that have been proposed, the use of magnetic nanoparticles app
Externí odkaz:
https://doaj.org/article/5f31bb91b9c6450a854c9579182ecffd
Autor:
Meray Serdar, Josephine Herz, Karina Kempe, Elke Winterhager, Holger Jastrow, Rolf Heumann, Ursula Felderhoff-Müser, Ivo Bendix
Publikováno v:
Frontiers in Neurology, Vol 9 (2018)
Prematurely born infants are highly susceptible to various environmental factors, such as inflammation, drug exposure, and also high environmental oxygen concentrations. Hyperoxia induces perinatal brain injury affecting white and gray matter develop
Externí odkaz:
https://doaj.org/article/81ab30f2e0614968beabbc241ad6f1b8
Autor:
Tsvetan Serchov, Rolf Heumann
Publikováno v:
Frontiers in Neurology, Vol 8 (2017)
The small GTPase Ras is a universal eukaryotic cytoplasmic membrane-anchored protein, which regulates diverse downstream signal transduction pathways that play an important role in the proper functioning of neurons. Ras activity is a central regulato
Externí odkaz:
https://doaj.org/article/b94470a28948495faea6313826fbb6d7
Publikováno v:
International Journal of Molecular Sciences, Vol 19, Iss 12, p 4052 (2018)
Cellular activation of RAS GTPases into the GTP-binding “ON„ state is a key switch for regulating brain functions. Molecular protein structural elements of rat sarcoma (RAS) and RAS homolog protein enriched in brain (RHEB) GTPases involved in thi
Externí odkaz:
https://doaj.org/article/770bd30c99ae4d1596ed6730d571264a
Autor:
Yvonne Imielski, Jens C Schwamborn, Patrick Lüningschrör, Peter Heimann, Magdalena Holzberg, Hendrikje Werner, Oliver Leske, Andreas W Püschel, Sylvie Memet, Rolf Heumann, Alain Israel, Christian Kaltschmidt, Barbara Kaltschmidt
Publikováno v:
PLoS ONE, Vol 7, Iss 2, p e30838 (2012)
Cognitive decline during aging is correlated with a continuous loss of cells within the brain and especially within the hippocampus, which could be regenerated by adult neurogenesis. Here we show that genetic ablation of NF-κB resulted in severe def
Externí odkaz:
https://doaj.org/article/53857d67d18447c4942306c5225d5d8d
Autor:
Pauline Lafenetre, Oliver Leske, Zhanlu Ma-Högemeie, Aiden Haghikia, Zoe Bichler, Petra Wahle, Rolf Heumann
Publikováno v:
Frontiers in Behavioral Neuroscience, Vol 3 (2010)
Running is a potent stimulator of cell proliferation in the adult dentate gyrus and these newly generated hippocampal neurons seem to be implicated in memory functions. Here we have used a mouse model expressing activated Ras under the direction of t
Externí odkaz:
https://doaj.org/article/b078374559ed4272b243cfb52e1484c3
Autor:
Peter Scherman, Pernilla Hansdotter, Erik Holmberg, Frank Viborg Mortensen, Sune H. Petersen, Magnus Rizell, Peter Naredi, Ingvar Syk, Peer Wille-Jørgensen, Erzsébet Horváth-Puhó, Søren Laurberg, Lars Påhlman, Andrew Renehan, Kenneth Smedh, Henrik Christensen, Jesper Dan Nielsen, Per Jess, Allan Gorm Pedersen, Mogens Rørbæk Madsen, Per Vadgaard Andersen, Erling Østergaard, Pernilla Hansdotter Andersson, Jonas Bengtsson, Mats Bragmark, Pamela Buchwald, Monika Egenvall, Parastau Farahnak, Joakim Folkesson, Michael Goldinger, Rolf Heuman, Kenneth Lindberg, Anna Martling, Pia Näsvall, Johan Ottosson, Birger Sandzén, Carlos Barberousse
Publikováno v:
Scherman, P, Hansdotter, P, Holmberg, E, Viborg Mortensen, F, Petersen, S H, Rizell, M, Naredi, P, Syk, I & COLOFOL Study Group 2023, ' High resection rates of colorectal liver metastases after standardized follow-up and multimodal management : an outcome study within the COLOFOL trial ', HPB, vol. 25, no. 7, pp. 766-774 . https://doi.org/10.1016/j.hpb.2023.03.003
Scherman, P, Hansdotter, P, Holmberg, E, Viborg Mortensen, F, Petersen, S H, Rizell, M, Naredi, P, Syk, I, COLOFOL study group & Nielsen, J D 2023, ' High resection rates of colorectal liver metastases after standardized follow-up and multimodal management : an outcome study within the COLOFOL trial ', H P B . https://doi.org/10.1016/j.hpb.2023.03.003
Scherman, P, Hansdotter, P, Holmberg, E, Viborg Mortensen, F, Petersen, S H, Rizell, M, Naredi, P, Syk, I, COLOFOL study group & Nielsen, J D 2023, ' High resection rates of colorectal liver metastases after standardized follow-up and multimodal management : an outcome study within the COLOFOL trial ', H P B, vol. 25, no. 7, pp. 766-774 . https://doi.org/10.1016/j.hpb.2023.03.003
Scherman, P, Hansdotter, P, Holmberg, E, Viborg Mortensen, F, Petersen, S H, Rizell, M, Naredi, P, Syk, I, COLOFOL study group & Nielsen, J D 2023, ' High resection rates of colorectal liver metastases after standardized follow-up and multimodal management : an outcome study within the COLOFOL trial ', H P B . https://doi.org/10.1016/j.hpb.2023.03.003
Scherman, P, Hansdotter, P, Holmberg, E, Viborg Mortensen, F, Petersen, S H, Rizell, M, Naredi, P, Syk, I, COLOFOL study group & Nielsen, J D 2023, ' High resection rates of colorectal liver metastases after standardized follow-up and multimodal management : an outcome study within the COLOFOL trial ', H P B, vol. 25, no. 7, pp. 766-774 . https://doi.org/10.1016/j.hpb.2023.03.003
Background: Outcome after colorectal liver metastases (CRLM) resection has improved over time, despite increased resection rates. Hence, it's crucial to identify all patients possible to treat with curative intent. The objectives of this study were t