A safety screening platform for individualized cardiotoxicity assessment

Autor: Verena Schwach, Rolf H. Slaats, Carla Cofiño-Fabres, Simone A. ten Den, José M. Rivera-Arbeláez, Maureen Dannenberg, Chiara van Boheemen, Marcelo C. Ribeiro, Sabina Y. van der Zanden, Edgar E. Nollet, Jolanda van der Velden, Jacques Neefjes, Lu Cao, Robert Passier

Publikováno v: iScience, Vol 27, Iss 3, Pp 109139- (2024)

Summary: Cardiotoxicity remains a major cause of drug withdrawal, partially due to lacking predictability of animal models. Additionally, risk of cardiotoxicity following treatment of cancer patients is treatment limiting. It is unclear which patient

Externí odkaz: https://doaj.org/article/53a15164b1784b66b4caea6027524cc5

Monitoring Contractile Cardiomyocytes via Impedance Using Multipurpose Thin Film Ruthenium Oxide Electrodes

Autor: Esther Tanumihardja, Douwe S. de Bruijn, Rolf H. Slaats, Wouter Olthuis, Albert van den Berg

Publikováno v: Sensors, Vol 21, Iss 4, p 1433 (2021)

A ruthenium oxide (RuOx) electrode was used to monitor contractile events of human pluripotent stem cells-derived cardiomyocytes (hPSC-CMs) through electrical impedance spectroscopy (EIS). Using RuOx electrodes presents an advantage over standard thi

Externí odkaz: https://doaj.org/article/55c81d9314f0403aaadbb62ca934cd81

A New Versatile Platform for Assessment of Improved Cardiac Performance in Human-Engineered Heart Tissues

Autor: Marcelo C. Ribeiro, José M. Rivera-Arbeláez, Carla Cofiño-Fabres, Verena Schwach, Rolf H. Slaats, Simone A. ten Den, Kim Vermeul, Albert van den Berg, José M Pérez-Pomares, Loes I. Segerink, Juan A. Guadix, Robert Passier

Publikováno v: Journal of Personalized Medicine; Volume 12; Issue 2; Pages: 214
Journal of Personalized Medicine, 12(2):214. MDPI

Cardiomyocytes derived from human pluripotent stem cells (hPSC-CMs) hold a great potential as human in vitro models for studying heart disease and for drug safety screening. Nevertheless, their associated immaturity relative to the adult myocardium l

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d8ec2aa33856e048e82b0fb5e9687d9

Measuring Both pH and O

Autor: Esther, Tanumihardja, Rolf H, Slaats, Andries D, van der Meer, Robert, Passier, Wouter, Olthuis, Albert, van den Berg

Publikováno v: ACS Sensors

In vitro studies which focus on cellular metabolism can benefit from time-resolved readouts from the living cells. pH and O2 concentration are fundamental parameters upon which cellular metabolism is often inferred. This work demonstrates a novel use

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::f9f40ca16bafb72953c6035703f01121
https://pubmed.ncbi.nlm.nih.gov/33371688

A cardiomyocyte show of force

Autor: Mireille Maria Anna Elisabeth Claessens, Verena Schwach, Robert Passier, Robert Molenaar, Leon G.J. Tertoolen, Christine L. Mummery, Rolf H. Slaats, Marcelo C. Ribeiro, José M. Rivera-Arbelaez, Berend J. van Meer

Publikováno v: Journal of molecular and cellular cardiology, 141, 54-64. Academic Press
Journal of Molecular and Cellular Cardiology, 141, 54-64. ELSEVIER SCI LTD

Cardiovascular disease is often associated with cardiac remodeling, including cardiac fibrosis, which may lead to increased stiffness of the heart wall. This stiffness in turn may cause subsequent failure of cardiac myocytes, however the response of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5371b40de7a201d311c8754c90b2c34
https://hdl.handle.net/1887/3181216