Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Rolf Fautz"'
Publikováno v:
Genes and Environment, Vol 40, Iss 1, Pp 1-3 (2018)
Abstract We have demonstrated that retrospective evaluation of existing data of in vitro chromosomal aberration test using the new cytotoxicity indices RICC (relative increase in cell count) or RPD (relative population doubling) reduces the false-pos
Externí odkaz:
https://doaj.org/article/b3f8b5ae3e7b4bf9a06d30c83c16a84c
Tolerability and Cross-reactivity of 3 New Hair Colorants in p-Phenylenediamine-Allergic Individuals
Autor:
Lukas Koch, Karin Plaschg, Anne Fuchs, Jonathan Wood, Rolf Fautz, Birger Kränke, Werner Aberer, Brunhilde Blömeke
Publikováno v:
Dermatitis : contact, atopic, occupational, drug. 33(2)
Autor:
Petra Renk-Schmehl, Kordula Schlotmann, Maya Krasteva, Rolf Fautz, Monika Kock, Thomas Koch, Madalina Caratas-Perifan, Anne Fuchs
Publikováno v:
European Journal of Dermatology. 30:377-388
Background A previous analysis of undesirable events (UEvs), reported to four major companies following the use of hair-colouring products in Europe, showed that the reporting rates were stable for both oxidative and direct hair-colouring products ov
Publikováno v:
Toxicology Letters. 316:1-9
Threshold of Toxicological Concern (TTC) is a promising approach for evaluating the human health risk for systemic toxicity when there is a lack of toxicological information. The threshold for systemic toxicity is reportedly 1800, 540, and 90 μg/day
Autor:
Peter Kasper, Rolf Fautz, Andreas Zeller, Frank Bringezu, Stefan Pfuhler, Nicola J. Hewitt, Silvio Albertini, Yasmin Dietz, Andreas Czich, Annette Kirst
Publikováno v:
Mutagenesis. 33:179-193
Genotoxicity testing is an important part of standard safety testing strategies. Animal studies have always been a key component, either as a mandatory part of the regulatory test battery, or to follow-up questionable in vitro findings. The strengths
Publikováno v:
Genes and Environment
Genes and Environment, Vol 40, Iss 1, Pp 1-3 (2018)
Genes and Environment, Vol 40, Iss 1, Pp 1-3 (2018)
We have demonstrated that retrospective evaluation of existing data of in vitro chromosomal aberration test using the new cytotoxicity indices RICC (relative increase in cell count) or RPD (relative population doubling) reduces the false-positive rat
Autor:
Wim J.A. Meuling, Hervé Toutain, Rolf Fautz, Wouter H.J. Vaes, Julie A. Skare, W. Steiling, Kenneth R. Wehmeyer, Gerhard J. Nohynek, Eric K. Dufour, Mario Bramante, Albertus Th H.J. de Bie
Publikováno v:
Food and Chemical Toxicology. 81:71-80
Systemic exposure was measured in humans after hair dyeing with oxidative hair dyes containing 2.0% (A) or 1.0% (B) [14C]-p-phenylenediamine (PPD). Hair was dyed, rinsed, dried, clipped and shaved; blood and urine samples were collected for 48 hours
Use of Human In Vitro Skin Models for Accurate and Ethical Risk Assessment: Metabolic Considerations
Autor:
Ellen Fritsche, Joan Eilstein, Alain Latil, Carsten Goebel, João Barroso, Gladys Ouedraogo, Claire Moore, Daniel Duche, Kerstin Reisinger, Stefan Pfuhler, Pierre Aeby, Julia Kenny, Jochen Kuehnl, Robert Edwards, Nicola J. Hewitt, Julia Scheel, Rolf Fautz
Publikováno v:
Toxicological Sciences. 133:209-217
Several human skin models employing primary cells and immortalized cell lines used as monocultures or combined to produce reconstituted 3D skin constructs have been developed. Furthermore, these models have been included in European genotoxicity and
Autor:
Thomas L. Diepgen, Ian Kimber, Pieter Jan Coenraads, Maya Krasteva, Rolf Fautz, Axel Schnuch, Anne Fuchs, Brunhilde Blömeke, G. F. Gerberick, Werner Schuh, Harald Schlatter, J. Pungier, Carsten Goebel, James S. Taylor, J.F. Nicolas
Publikováno v:
Regulatory toxicology and pharmacology, 64(3), 459-465. ACADEMIC PRESS INC ELSEVIER SCIENCE
With the availability of the local lymph node assay, and the ability to evaluate effectively the relative skin sensitizing potency of contact allergens, a model for quantitative-risk-assessment (QRA) has been developed. This QRA process comprises: (a
Publikováno v:
Toxicology Letters. 295:S162