Identification of a mitochondrial target of thiazolidinedione insulin sensitizers (mTOT)--relationship to newly identified mitochondrial pyruvate carrier proteins.

Autor: Jerry R Colca, William G McDonald, Gregory S Cavey, Serena L Cole, Danielle D Holewa, Angela S Brightwell-Conrad, Cindy L Wolfe, Jean S Wheeler, Kristin R Coulter, Peter M Kilkuskie, Elena Gracheva, Yulia Korshunova, Michelle Trusgnich, Robert Karr, Sandra E Wiley, Ajit S Divakaruni, Anne N Murphy, Patrick A Vigueira, Brian N Finck, Rolf F Kletzien

Publikováno v: PLoS ONE, Vol 8, Iss 5, p e61551 (2013)

Thiazolidinedione (TZD) insulin sensitizers have the potential to effectively treat a number of human diseases, however the currently available agents have dose-limiting side effects that are mediated via activation of the transcription factor PPARγ

Externí odkaz: https://doaj.org/article/810bfe5fc88043a1a3d87fdcdaabf016

The beneficial metabolic effects of insulin sensitizers are not attenuated by mitochondrial pyruvate carrier 2 hypomorphism

Autor: Lalita Oonthonpan, Rolf F. Kletzien, Eric B. Taylor, Jerry R. Colca, Serena L. Cole, George G. Schweitzer, William G. McDonald, Patrick A. Vigueira, Wesley T. Hodges, Brian N. Finck, Kyle S. McCommis

Publikováno v: Experimental Physiology. 102:985-999

Rosiglitazone and pioglitazone are thiazolidinedione (TZD) compounds that have been used clinically as insulin-sensitizing drugs and are generally believed to mediate their effects via activation of the peroxisome proliferator-activated receptor γ (

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c4f7b85b1cc3600423efdcc0a0c3e843
https://doi.org/10.1113/ep086380

Mitochondrial Pyruvate Carrier 2 Hypomorphism in Mice Leads to Defects in Glucose-Stimulated Insulin Secretion

Autor: Kyle S. McCommis, Rolf F. Kletzien, Brian N. Finck, Xiaorong Fu, Patrick A. Vigueira, Shawn C. Burgess, Serena L. Cole, Jerry R. Colca, Kari T. Chambers, William G. McDonald, George G. Schweitzer, Maria S. Remedi

Publikováno v: Cell Reports, Vol 7, Iss 6, Pp 2042-2053 (2014)

SummaryCarrier-facilitated pyruvate transport across the inner mitochondrial membrane plays an essential role in anabolic and catabolic intermediary metabolism. Mitochondrial pyruvate carrier 2 (Mpc2) is believed to be a component of the complex that

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b6e5ee8cbc898411b403e220f21c7de

Insulin Sensitizing Pharmacology of Thiazolidinediones Correlates with Mitochondrial Gene Expression rather than Activation of PPARγ

Autor: Charles W. Bolten, Patrick M. Blanner, William G. McDonald, Nicholas R. Staten, Richard A. Mazzarella, Graciela B. Arhancet, Martin F. Meier, David J. Weiss, Patrick M. Sullivan, Alexander E. Hromockyj, Rolf F. Kletzien, Jerry R. Colca

Publikováno v: Gene Regulation and Systems Biology, Vol 1, Pp 73-82 (2007)
Gene Regulation and Systems Biology, Vol 1 (2007)
Gene Regulation and Systems Biology

Insulin sensitizing thiazolidinediones (TZDs) are generally considered to work as agonists for the nuclear receptor peroxisome proliferative activated receptor-gamma (PPAR gamma). However, TZDs also have acute, non-genomic metabolic effects and it is

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb348030b9f5e16dbbb594e56cee8404
http://la-press.com/article.php?article_id=370

What has prevented the expansion of insulin sensitisers?

Autor: Rolf F. Kletzien, Jerry R. Colca

Publikováno v: Expert Opinion on Investigational Drugs. 15:205-210

The ability to improve insulin sensitivity with synthetic compounds was uncovered by empirical discoveries by Takeda in the late 1970s. The potential of a class of thiazolidinediones for the treatment of Type 2 diabetes, by decreasing glucose and tri

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f1616e9b08e8e457399920ba391e8f02
https://doi.org/10.1517/13543784.15.3.205