Výsledky vyhledávání - "Rolf F Barth"

Akademický článek

Phase I trial of intracerebral convection-enhanced delivery of carboplatin for treatment of recurrent high-grade gliomas.

Autor: Joshua L Wang, Rolf F Barth, Robert Cavaliere, Vinay K Puduvalli, Pierre Giglio, Russell R Lonser, J Bradley Elder

Publikováno v: PLoS ONE, Vol 15, Iss 12, p e0244383 (2020)

BackgroundCarboplatin is a potent cytoreductive agent for a variety of solid tumors. However, when delivered systemically, clinical efficacy for the treatment of high grade gliomas is poor due to limited penetration across the blood-brain barrier (BB

Externí odkaz: https://doaj.org/article/d53ef453fad44964bffeeb5c6f7a7ab6

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Akademický článek

Evaluation of sodium borocaptate (BSH) and boronophenylalanine (BPA) as boron delivery agents for neutron capture therapy (NCT) of cancer: an update and a guide for the future clinical evaluation of new boron delivery agents for NCT

Autor: Rolf F. Barth, Nilendu Gupta, Shinji Kawabata

Publikováno v: Cancer Communications, Vol 44, Iss 8, Pp 893-909 (2024)

Abstract Boron neutron capture therapy (BNCT) is a cancer treatment modality based on the nuclear capture and fission reactions that occur when boron‐10, a stable isotope, is irradiated with neutrons of the appropriate energy to produce boron‐11

Externí odkaz: https://doaj.org/article/1110ba6dabf644cb9d8602bc5ff56dd4

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Akademický článek

Boron neutron capture therapy of cancer: where do we stand now?

Autor: Rolf F. Barth, Gong Wu, Maria da Graca H. Vicente, John C Grecula, Nilendu Gupta

Publikováno v: Cancer Communications, Vol 44, Iss 8, Pp 889-892 (2024)

Externí odkaz: https://doaj.org/article/abf70e868b7b41dc8fc4b463d23ace22

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Akademický článek

Biodistribution and subcellular localization of an unnatural boron-containing amino acid (cis-ABCPC) by imaging secondary ion mass spectrometry for neutron capture therapy of melanomas and gliomas.

Autor: Subhash Chandra, Rolf F Barth, Syed A Haider, Weilian Yang, Tianyao Huo, Aarif L Shaikh, George W Kabalka

Publikováno v: PLoS ONE, Vol 8, Iss 9, p e75377 (2013)

The development of new boron-delivery agents is a high priority for improving the effectiveness of boron neutron capture therapy. In the present study, 1-amino-3-borono-cyclopentanecarboxylic acid (cis-ABCPC) as a mixture of its L- and D-enantiomers

Externí odkaz: https://doaj.org/article/910e46bc381748bba7395262cbd3c1e9

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Akademický článek

Preparation, biodistribution and neurotoxicity of liposomal cisplatin following convection enhanced delivery in normal and F98 glioma bearing rats.

Autor: Tianyao Huo, Rolf F Barth, Weilian Yang, Robin J Nakkula, Rumiana Koynova, Boris Tenchov, Abhik Ray Chaudhury, Lawrence Agius, Teni Boulikas, Helene Elleaume, Robert J Lee

Publikováno v: PLoS ONE, Vol 7, Iss 11, p e48752 (2012)

The purpose of this study was to evaluate two novel liposomal formulations of cisplatin as potential therapeutic agents for treatment of the F98 rat glioma. The first was a commercially produced agent, Lipoplatin™, which currently is in a Phase III

Externí odkaz: https://doaj.org/article/1b6974913ecb4eb8845048e6d64fdfc4

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Akademický článek

Unique in vitro and in vivo thrombopoietic activities of ingenol 3,20 dibenzoate, a Ca(++)-independent protein kinase C isoform agonist.

Autor: Frederick K Racke, Maureen Baird, Rolf F Barth, Tianyao Huo, Weilian Yang, Nilendu Gupta, Michael Weldon, Heather Rutledge

Publikováno v: PLoS ONE, Vol 7, Iss 12, p e51059 (2012)

Thrombopoiesis following severe bone marrow injury frequently is delayed, thereby resulting in life-threatening thrombocytopenia for which there are limited treatment options. The reasons for these delays in recovery are not well understood. Protein

Externí odkaz: https://doaj.org/article/f3cf12cf89db4eb1a509115e1b48851b

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Akademický článek

Boron delivery agents for neutron capture therapy of cancer

Autor: Rolf F. Barth, Peng Mi, Weilian Yang

Publikováno v: Cancer Communications, Vol 38, Iss 1, Pp 1-15 (2018)

Abstract Boron neutron capture therapy (BNCT) is a binary radiotherapeutic modality based on the nuclear capture and fission reactions that occur when the stable isotope, boron-10, is irradiated with neutrons to produce high energy alpha particles. T

Externí odkaz: https://doaj.org/article/472964df391247d38c4286f4705b3c86

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