Zobrazeno 1 - 10
of 276
pro vyhledávání: '"Rolf E Brenner"'
Autor:
Amelie Kuhn, Markus Huber-Lang, Sebastian Weckbach, Jana Riegger, Graciosa Q. Teixeira, Volker Rasche, Jörg Fiedler, Cornelia Neidlinger-Wilke, Rolf E. Brenner
Publikováno v:
Biomedicines, Vol 12, Iss 8, p 1692 (2024)
Previous studies indicate an implication of the terminal complement complex (TCC) in disc degeneration (DD). To investigate the functional role of TCC in trauma-induced DD in vivo, the model of endplate (EP) drilling was first applied in rabbits usin
Externí odkaz:
https://doaj.org/article/d75f8a054d524407b6710a36f5300518
Autor:
Jana Riegger, Rolf E Brenner
Publikováno v:
eLife, Vol 12 (2023)
Accumulation of dysfunctional chondrocytes has detrimental consequences on the cartilagehomeostasis and is thus thought to play a crucial role during the pathogenesis of osteoarthritis(OA). However, the underlying mechanisms of phenotypical alteratio
Externí odkaz:
https://doaj.org/article/0a01d1ef837042f5a3d0fce7af5d945b
Autor:
Lena Huber, David Gvaramia, Johann Kern, Yvonne Jakob, Frank G Zoellner, Daniela Hirsch, Roman Breiter, Rolf E Brenner, Nicole Rotter
Publikováno v:
Journal of Tissue Engineering, Vol 13 (2022)
Nasal septum defects can currently only be reconstructed using autologous cartilage grafts. In this study, we examine the reconstruction of septal cartilage defects in a rabbit model using porcine decellularized nasal septal cartilage (DNSC) function
Externí odkaz:
https://doaj.org/article/4a8fc47ffff9419b87b1c18355b5d13a
Publikováno v:
Frontiers in Bioengineering and Biotechnology, Vol 10 (2022)
Joint injuries are known to induce pathomechanisms that might lead to posttraumatic osteoarthritis (PTOA). In this regard, statins with their pleiotropic effects could represent potential therapeutic agents in preventing the development of PTOA. Ther
Externí odkaz:
https://doaj.org/article/d9683892e777422da5c2e81e963c0665
Autor:
Amelie Kuhn, Jana Riegger, Graciosa Q. Teixeira, Markus Huber-Lang, John D. Lambris, Cornelia Neidlinger-Wilke, Rolf E. Brenner
Publikováno v:
Cells, Vol 12, Iss 6, p 887 (2023)
Terminal complement complex (TCC) deposition was identified in human degenerated discs. To clarify the role of terminal complement activation in disc degeneration (DD), we investigated respective activating mechanisms and cellular effects in annulus
Externí odkaz:
https://doaj.org/article/503a1bd248494d9096c65bd6142d786d
Autor:
Jana Riegger, Helga Joos, Valentin Möhler, Frank Leucht, Katrin Rading, Christian Kubisch, Anita Ignatius, Markus Huber-Lang, Rolf E. Brenner
Publikováno v:
Biomolecules, Vol 13, Iss 2, p 216 (2023)
The terminal complement complex (TCC) has been described as a potential driver in the pathogenesis of posttraumatic osteoarthritis (PTOA). However, sublytic TCC deposition might also play a crucial role in bone development and regeneration. Therefore
Externí odkaz:
https://doaj.org/article/06e9fb6a51624bc89037d7ad2ca29e92
Publikováno v:
Bone Reports, Vol 14, Iss , Pp 100917- (2021)
Externí odkaz:
https://doaj.org/article/08219e3ca89647d997f2376f55d4ee3c
Autor:
Marietta Herrmann, Solvig Diederichs, Svitlana Melnik, Jana Riegger, Drenka Trivanović, Shushan Li, Zsuzsa Jenei-Lanzl, Rolf E. Brenner, Markus Huber-Lang, Frank Zaucke, Frank A. Schildberg, Susanne Grässel
Publikováno v:
Frontiers in Bioengineering and Biotechnology, Vol 8 (2021)
The incidence of musculoskeletal diseases is steadily increasing with aging of the population. In the past years, extracellular vesicles (EVs) have gained attention in musculoskeletal research. EVs have been associated with various musculoskeletal pa
Externí odkaz:
https://doaj.org/article/174cbfd129a943ed8a6564560b186d55
Autor:
Hanna Tritschler, Konrad Fischer, Jochen Seissler, Jörg Fiedler, Rebecca Halbgebauer, Markus Huber-Lang, Angelika Schnieke, Rolf E. Brenner
Publikováno v:
Cells, Vol 10, Iss 8, p 2152 (2021)
Transplantation of xenogenic porcine chondrocytes could represent a future strategy for the treatment of human articular cartilage defects. Major obstacles are humoral and cellular rejection processes triggered by xenogenic epitopes like α-1,3-Gal a
Externí odkaz:
https://doaj.org/article/48f44517d73c4437822c6f56ca9ecaaa
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 14, p 7247 (2021)
The hexosamine biosynthetic pathway (HBP) is essential for the production of uridine diphosphate N-acetylglucosamine (UDP-GlcNAc), the building block of glycosaminoglycans, thus playing a crucial role in cartilage anabolism. Although O-GlcNAcylation
Externí odkaz:
https://doaj.org/article/b0847e7a3bed4102b0a9be521cf46f2c