Zobrazeno 1 - 10
of 118
pro vyhledávání: '"Rolf D Horstmann"'
Autor:
Christian G Meyer, Norbert Reiling, Christa Ehmen, Gerd Ruge, Ellis Owusu-Dabo, Rolf D Horstmann, Thorsten Thye
Publikováno v:
PLoS ONE, Vol 11, Iss 5, p e0156046 (2016)
Toll like receptors (TLR) are key elements of the innate immune response and involved in the recognition of pathogens. To test common and rare TLR variants involved in susceptibility or resistance to infection with Mycobacterium tuberculosis we scree
Externí odkaz:
https://doaj.org/article/da2ed85bbb0a4379bd758ad52931cb89
Autor:
Kathrin Schuldt, Christa Ehmen, Jennifer Evans, Juergen May, Daniel Ansong, Juergen Sievertsen, Birgit Muntau, Gerd Ruge, Tsiri Agbenyega, Rolf D Horstmann
Publikováno v:
PLoS ONE, Vol 9, Iss 12, p e115770 (2014)
BACKGROUND: Two recent reports have identified the Endothelial Protein C Receptor (EPCR) as a key molecule implicated in severe malaria pathology. First, it was shown that EPCR in the human microvasculature mediates sequestration of Plasmodium falcip
Externí odkaz:
https://doaj.org/article/215ef6dace934265bcbdd91f37b23ef0
Autor:
Kathrin Schuldt, Cosima C Kretz, Christian Timmann, Jürgen Sievertsen, Christa Ehmen, Claudia Esser, Wibke Loag, Daniel Ansong, Carmen Dering, Jennifer Evans, Andreas Ziegler, Jürgen May, Peter H Krammer, Tsiri Agbenyega, Rolf D Horstmann
Publikováno v:
PLoS Genetics, Vol 7, Iss 5, p e1002066 (2011)
Human genetics and immune responses are considered to critically influence the outcome of malaria infections including life-threatening syndromes caused by Plasmodium falciparum. An important role in immune regulation is assigned to the apoptosis-sig
Externí odkaz:
https://doaj.org/article/abb074d2235a42f384577f00bcbbcbe7
Autor:
Thorsten Thye, Stefan Niemann, Kerstin Walter, Susanne Homolka, Christopher D Intemann, Margaret Amanua Chinbuah, Anthony Enimil, John Gyapong, Ivy Osei, Ellis Owusu-Dabo, Sabine Rüsch-Gerdes, Rolf D Horstmann, Stefan Ehlers, Christian G Meyer
Publikováno v:
PLoS ONE, Vol 6, Iss 6, p e20908 (2011)
Structural variants of the Mannose Binding Lectin (MBL) cause quantitative and qualitative functional deficiencies, which are associated with various patterns of susceptibility to infectious diseases and other disorders. We determined genetic MBL var
Externí odkaz:
https://doaj.org/article/05e49e2dfe42446ab8b7ced033249e3a
Autor:
Christopher D Intemann, Thorsten Thye, Stefan Niemann, Edmund N L Browne, Margaret Amanua Chinbuah, Anthony Enimil, John Gyapong, Ivy Osei, Ellis Owusu-Dabo, Susanne Helm, Sabine Rüsch-Gerdes, Rolf D Horstmann, Christian G Meyer
Publikováno v:
PLoS Pathogens, Vol 5, Iss 9, p e1000577 (2009)
The human immunity-related GTPase M (IRGM) has been shown to be critically involved in regulating autophagy as a means of disposing cytosolic cellular structures and of reducing the growth of intracellular pathogens in vitro. This includes Mycobacter
Externí odkaz:
https://doaj.org/article/dc0ceb775e4746f6b7c8dd24c0f8535d
Autor:
Thorsten Thye, Genevieve Scarisbrick, Edmund N L Browne, Margaret Amanua Chinbuah, John Gyapong, Ivy Osei, Ellis Owusu-Dabo, Stefan Niemann, Sabine Rüsch-Gerdes, Christian G Meyer, Rolf D Horstmann
Publikováno v:
PLoS ONE, Vol 4, Iss 7, p e6307 (2009)
The gene of Cytotoxic T Lymphocyte-associated Antigen 4 (CTLA4), a negative regulator of T lymphocytes, contains a single-nucleotide polymorphism (SNP) at position +6230A->G (ct60A->G), which has been found associated with several autoimmune diseases
Externí odkaz:
https://doaj.org/article/9bdecb079b1948f48b21c8ecc8c67ef5
Autor:
Thorsten Thye, Edmund N Browne, Margaret A Chinbuah, John Gyapong, Ivy Osei, Ellis Owusu-Dabo, Norbert W Brattig, Stefan Niemann, Sabine Rüsch-Gerdes, Rolf D Horstmann, Christian G Meyer
Publikováno v:
PLoS ONE, Vol 4, Iss 5, p e5420 (2009)
Evidence from genetic association and twin studies indicates that susceptibility to tuberculosis (TB) is under genetic control. One gene implicated in susceptibility to TB is that encoding interleukin-10 (IL10). In a group of 2010 Ghanaian patients w
Externí odkaz:
https://doaj.org/article/7a48301ca91d4525b2222467107c2272
Autor:
Christian Timmann, Jennifer A Evans, Inke R König, André Kleensang, Franz Rüschendorf, Julia Lenzen, Jürgen Sievertsen, Christian Becker, Yeetey Enuameh, Kingsley Osei Kwakye, Ernest Opoku, Edmund N L Browne, Andreas Ziegler, Peter Nürnberg, Rolf D Horstmann
Publikováno v:
PLoS Genetics, Vol 3, Iss 3, p e48 (2007)
Although balancing selection with the sickle-cell trait and other red blood cell disorders has emphasized the interaction between malaria and human genetics, no systematic approach has so far been undertaken towards a comprehensive search for human g
Externí odkaz:
https://doaj.org/article/012bf775d8664a34810c10cc87826067
Autor:
Kathrin Schuldt, Christa Ehmen, Juergen Sievertsen, Jennifer Evans, Juergen May, Daniel Ansong, Birgit Muntau, Gerd Ruge, Christian Timmann, Tsiri Agbenyega, Rolf D. Horstmann, Thorsten Thye
Publikováno v:
G3: Genes, Genomes, Genetics, Vol 7, Iss 3, Pp 859-864 (2017)
In a recent report, the cellular receptor CD55 was identified as a molecule essential for the invasion of human erythrocytes by Plasmodium falciparum, the causal agent of the most severe form of malaria. As this invasion process represents a critical
Externí odkaz:
https://doaj.org/article/1646d1ca51c348d1a4f251f4ae8916d1
Autor:
Jürgen May, Kathrin Schuldt, Rolf D. Horstmann, Wibke Loag, Gerd Ruge, Thorsten Thye, Jennifer Evans, Daniel Ansong, Tsiri Agbenyega
Publikováno v:
Journal of Human Genetics
Recently, a common genetic variant E756del in the human gene PIEZO1 was associated with protection from severe malaria. Here, we performed a genetic association study of this gain-of-function variant in a large case-control study including 4149 child
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cad9669a8ece6eb509dbd0007899acfd
http://europepmc.org/articles/PMC8727285
http://europepmc.org/articles/PMC8727285