Zobrazeno 1 - 10
of 123
pro vyhledávání: '"Rolf, Zeller"'
Autor:
Marta Losa, Iros Barozzi, Marco Osterwalder, Viviana Hermosilla-Aguayo, Angela Morabito, Brandon H. Chacón, Peyman Zarrineh, Ausra Girdziusaite, Jean Denis Benazet, Jianjian Zhu, Susan Mackem, Terence D. Capellini, Diane Dickel, Nicoletta Bobola, Aimée Zuniga, Axel Visel, Rolf Zeller, Licia Selleri
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-20 (2023)
Abstract A lingering question in developmental biology has centered on how transcription factors with widespread distribution in vertebrate embryos can perform tissue-specific functions. Here, using the murine hindlimb as a model, we investigate the
Externí odkaz:
https://doaj.org/article/7c9a9b83afdc4ea8afaf6d100fd069b1
Publikováno v:
STAR Protocols, Vol 4, Iss 4, Pp 102603- (2023)
Summary: Tissue autofluorescence poses significant challenges for RNA and protein analysis using fluorescence-based techniques. Here, we present a protocol that combines oxidation-mediated autofluorescence reduction with detergent-based tissue permea
Externí odkaz:
https://doaj.org/article/95195cdc884e4e449676aff05df96ce4
Autor:
Jonas Malkmus, Laurène Ramos Martins, Shalu Jhanwar, Bonnie Kircher, Victorio Palacio, Rushikesh Sheth, Francisca Leal, Amandine Duchesne, Javier Lopez-Rios, Kevin A. Peterson, Robert Reinhardt, Koh Onimaru, Martin J. Cohn, Aimée Zuniga, Rolf Zeller
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
The BMP antagonist Gremlin1 balances BMP and SHH signalling, endowing limb bud development with robustness. Here, the authors identify enhancers controlling Grem1 levels in an additive, and spatial regulation in a synergistic manner, providing digit
Externí odkaz:
https://doaj.org/article/8daa3afd4ca340eaad289f8348f3805b
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
The vertebrate limb bud is a paradigm to uncover the fundamental mechanisms that govern embryogenesis and evolutionary diversification. Here the authors compare mouse and chicken limb bud development to study the impact of genome evolution on conserv
Externí odkaz:
https://doaj.org/article/4f4c006c8e084f5fb6335b5b5fcf9b23
Autor:
Ines Desanlis, Yacine Kherdjemil, Alexandre Mayran, Yasser Bouklouch, Claudia Gentile, Rushikesh Sheth, Rolf Zeller, Jacques Drouin, Marie Kmita
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-10 (2020)
Pioneer factors direct cell fate through switching inaccessible chromatin to an accessible state at specific target enhancers. Here the authors show that HOX13 transcription factors have a pioneer activity which is required for the proper implementat
Externí odkaz:
https://doaj.org/article/f7f1aa4b6fd944ee94c69c85f704d178
Autor:
Kelsey H Elliott, Xiaoting Chen, Joseph Salomone, Praneet Chaturvedi, Preston A Schultz, Sai K Balchand, Jeffrey D Servetas, Aimée Zuniga, Rolf Zeller, Brian Gebelein, Matthew T Weirauch, Kevin A Peterson, Samantha A Brugmann
Publikováno v:
eLife, Vol 9 (2020)
Despite a common understanding that Gli TFs are utilized to convey a Hh morphogen gradient, genetic analyses suggest craniofacial development does not completely fit this paradigm. Using the mouse model (Mus musculus), we demonstrated that rather tha
Externí odkaz:
https://doaj.org/article/659f921a3e85487a949e94d7fb166cc9
Autor:
Virginie Tissières, Florian Geier, Barbara Kessler, Eckhard Wolf, Rolf Zeller, Javier Lopez-Rios
Publikováno v:
Cell Reports, Vol 31, Iss 1, Pp - (2020)
Summary: Digit loss/reductions are evolutionary adaptations in cursorial mammals such as pigs. To gain mechanistic insight into these processes, we performed a comparative molecular analysis of limb development in mouse and pig embryos, which reveale
Externí odkaz:
https://doaj.org/article/01e3ba62cffb4d45a209cb6560090cb4
Autor:
Gretel Nusspaumer, Sumit Jaiswal, Andrea Barbero, Robert Reinhardt, Dana Ishay Ronen, Alexander Haumer, Thomas Lufkin, Ivan Martin, Rolf Zeller
Publikováno v:
Stem Cell Reports, Vol 9, Iss 4, Pp 1124-1138 (2017)
Bone-derived mesenchymal stromal cells (MSCs) differentiate into multiple lineages including chondro- and osteogenic fates and function in establishing the hematopoietic compartment of the bone marrow. Here, we analyze the emergence of different MSC
Externí odkaz:
https://doaj.org/article/a21df5e4da304510bb3ca0b6ad018ab9
Autor:
Frédéric Laurent, Ausra Girdziusaite, Julie Gamart, Iros Barozzi, Marco Osterwalder, Jennifer A. Akiyama, Joy Lincoln, Javier Lopez-Rios, Axel Visel, Aimée Zuniga, Rolf Zeller
Publikováno v:
Cell Reports, Vol 19, Iss 8, Pp 1602-1613 (2017)
The HAND2 transcriptional regulator controls cardiac development, and we uncover additional essential functions in the endothelial to mesenchymal transition (EMT) underlying cardiac cushion development in the atrioventricular canal (AVC). In Hand2-de
Externí odkaz:
https://doaj.org/article/f88dd9f519ce4a2cbd3c44cff84ccf43
Autor:
Nathan J. VanDusen, Jose Casanovas, Joshua W. Vincentz, Beth A. Firulli, Marco Osterwalder, Javier Lopez-Rios, Rolf Zeller, Bin Zhou, Joaquim Grego-Bessa, José Luis De La Pompa, Weinian Shou, Anthony B. Firulli
Publikováno v:
Cell Reports, Vol 9, Iss 6, Pp 2071-2083 (2014)
The basic-helix-loop-helix (bHLH) transcription factor Hand2 plays critical roles during cardiac morphogenesis via expression and function within myocardial, neural crest, and epicardial cell populations. Here, we show that Hand2 plays two essential
Externí odkaz:
https://doaj.org/article/5eb81b79e4424059b0feed6fcefa3da6