Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Rolf, Studer"'
Autor:
Patrick Sieber, Anny Schäfer, Raphael Lieberherr, Silvia L. Caimi, Urs Lüthi, Jesper Ryge, Jan H. Bergmann, François Le Goff, Manuel Stritt, Peter Blattmann, Bérengère Renault, Patrick Rammelt, Bruno Sempere, Diego Freti, Rolf Studer, Eric S. White, Magdalena Birker-Robaczewska, Maxime Boucher, Oliver Nayler
Publikováno v:
JCI Insight, Vol 8, Iss 3 (2023)
In the progression phase of idiopathic pulmonary fibrosis (IPF), the normal alveolar structure of the lung is lost and replaced by remodeled fibrotic tissue and by bronchiolized cystic airspaces. Although these are characteristic features of IPF, kno
Externí odkaz:
https://doaj.org/article/7c0ad56ad83d41d4b075e65592ee536c
Autor:
Katarina Zmajkovicova, Yasmina Bauer, Katalin Menyhart, Marie Schnoebelen, Diego Freti, Maxime Boucher, Bérengère Renault, Rolf Studer, Magdalena Birker-Robaczewska, Axel Klenk, Oliver Nayler, John Gatfield
Publikováno v:
PLoS ONE, Vol 15, Iss 2, p e0228195 (2020)
Tissue fibrosis is a pathological condition characterized by uncontrolled fibroblast activation that ultimately leads to organ failure. The TGFβ1 pathway, one of the major players in establishment of the disease phenotype, is dependent on the transc
Externí odkaz:
https://doaj.org/article/282eb950f8d8439b83951dce674b541e
The Antifibrotic Activity of Prostacyclin Receptor Agonism Is Mediated through Inhibition of YAP/TAZ
Autor:
John Gatfield, Marie Schnoebelen, Katalin Menyhart, Katarina Zmajkovicova, Bérengère Renault, Matthias Bolinger, Rolf Studer, Yasmina Bauer, Oliver Nayler
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology. 60:578-591
Idiopathic pulmonary fibrosis is a life-threatening progressive disease characterized by loss of alveolar epithelial cells, inflammation, and aberrant fibroblast activation. The two currently approved therapies do not halt or reverse tissue remodelin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::46ef65a26b3065dc3249ab5a6c3a01b3
https://doi.org/10.1165/rcmb.2018-0142oc
https://doi.org/10.1165/rcmb.2018-0142oc
Autor:
Marc Iglarz, Toufiq Renno, Diego Freti, Dominique Valeyre, Marine Ponchon, Alain Calender, Jean François Bernaudin, Serge Lebecque, Abederrazzaq Bentaher, Daniel S. Strasser, Rolf Studer, Yves Pacheco
Publikováno v:
Experimental lung research. 44(1)
Nanoparticles are increasingly suspected as a strong etiologic factor of granuloma formation.The aim of our study was to compare lung inflammatory response and histology changes following exposure of mice to two widely used nanoparticles: carbon nano
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6fd3998b1d188f4f63cbc11a51d75852
https://pubmed.ncbi.nlm.nih.gov/29324063
https://pubmed.ncbi.nlm.nih.gov/29324063
Autor:
Luca, Piali, Magdalena, Birker-Robaczewska, Cyrille, Lescop, Sylvie, Froidevaux, Nicole, Schmitz, Keith, Morrison, Christopher, Kohl, Markus, Rey, Rolf, Studer, Enrico, Vezzali, Patrick, Hess, Martine, Clozel, Beat, Steiner, Martin H, Bolli, Oliver, Nayler
Publikováno v:
Pharmacology Research & Perspectives
Sphingosine‐1‐phosphate receptor 1 (S1P1) modulators sequester circulating lymphocytes within lymph nodes, thereby preventing potentially pathogenic autoimmune cells from exiting into the blood stream and reaching inflamed tissues. S1P1 receptor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::0454bce66af04dd6f9e57d2364b830fd
https://pubmed.ncbi.nlm.nih.gov/29226621
https://pubmed.ncbi.nlm.nih.gov/29226621
Publikováno v:
Cellular Signalling. 26:1576-1588
The sphingosine-1-phosphate (S1P) type 1 receptor (S1P1R) is a novel therapeutic target in lymphocyte-mediated autoimmune diseases. S1P1 receptor desensitization caused by synthetic S1P1 receptor agonists prevents T-lymphocyte egress from secondary l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3264da12f2e1db88179ad15fb917776
https://doi.org/10.1016/j.cellsig.2014.03.029
https://doi.org/10.1016/j.cellsig.2014.03.029
Autor:
Jérôme Segrestaa, Christophe Cattaneo, Annette Trébaul, Magali Vercauteren, Patrick Sieber, Doriane Eckert, Rolf Studer, Peter M.A. Groenen, Marco Garzotti, Oliver Nayler, Richard W. D. Welford
Publikováno v:
Scientific Reports
The biogenic amine serotonin (5-HT) is a multi-faceted hormone that is synthesized from dietary tryptophan with the rate limiting step being catalyzed by the enzyme tryptophan hydroxylase (TPH). The therapeutic potential of peripheral 5-HT synthesis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f688f24c81b0870bf6c64018d5265d6
https://doi.org/10.1038/srep30059
https://doi.org/10.1038/srep30059
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 343:547-555
{4-[(5,6-Diphenylpyrazin-2-yl)(isopropyl)amino]butoxy}acetic acid (ACT-333679) is the main metabolite of the selective prostacyclin (PGI(2)) receptor (IP receptor) agonist selexipag. The goal of this study was to determine the influence of IP recepto
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::aeacef8662c7eb6b55cd2e224fbee8c4
https://doi.org/10.1124/jpet.112.197152
https://doi.org/10.1124/jpet.112.197152
Autor:
Daniel S. Strasser, Changbin Qiu, Manuel Stritt, Anna K. Stalder, Bérengère Renault, Martine Clozel, Rolf Studer, Daniel Wanner, Katalin Kauser, Walter Fischli, Oliver Nayler, Patrick Hess, Nina Killer, Hervé Farine, Yasmina Bauer, Axel Klenk
Publikováno v:
Hypertension. 57:795-801
The renin-angiotensin system is a well-known regulator of blood pressure and plays an important role in the pathogenesis of cardiovascular disease and renal damage. Genetic factors, including single nucleotide polymorphisms and sex, are increasingly
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51b0df4632548cd53de70f65ddcf8a45
https://doi.org/10.1161/hypertensionaha.110.157206
https://doi.org/10.1161/hypertensionaha.110.157206
Autor:
Beat Steiner, Martin Bolli, Sylvie Froidevaux, Magdalena Birker-Robaczewska, Christopher Kohl, Keith Morrison, Markus Rey, Rolf Studer, Luca Piali, Patrick Hess, Nicole Schmitz, Enrico Vezzali, Oliver Nayler, Martine Clozel, Cyrille Lescop
Publikováno v:
Pharmacology Research & Perspectives. 5:e00370
Sphingosine-1-phosphate receptor 1 (S1P1 ) modulators sequester circulating lymphocytes within lymph nodes, thereby preventing potentially pathogenic autoimmune cells from exiting into the blood stream and reaching inflamed tissues. S1P1 receptor mod
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::625e01f90cf17442bb6bcdb45f31a7ed
https://doi.org/10.1002/prp2.370
https://doi.org/10.1002/prp2.370