Injurious ventilation strategies cause systemic release of IL-6 and MIP-2 in rats in vivo *

Autor: Rolf Göggel, Burkhard Lachmann, Serge J. C. Verbrugge, D. L. H. Poelma, Jack J. Haitsma, Stefan Uhlig

Publikováno v: Clinical Physiology and Functional Imaging. 23:349-353

Summary In vivo experiments showed no increased production of tumour necrosis factor (TNF) in response to injurious ventilation strategies in otherwise untreated animals. Because interleukin-6 (IL-6) and macrophage inflammatory protein-2 (MIP-2) are

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e2910ad6e2288bd20e4fbaa9418e3ebb
https://doi.org/10.1046/j.1475-0961.2003.00518.x

Platelet-Activating Factor–induced Pulmonary Edema Is Partly Mediated by Prostaglandin E2, E-Prostanoid 3-Receptors, and Potassium Channels

Autor: Rolf M. Nüsing, Sven Hoffman, Shuh Narumiya, Stefan Uhlig, Rolf Göggel

Publikováno v: American Journal of Respiratory and Critical Care Medicine. 166:657-662

Platelet-activating factor (PAF) is an important endogenous mediator of pulmonary edema in many models of acute lung injury. PAF triggers edema formation by simultaneous activation of two independent pathways; one is mediated by a cyclooxygenase meta

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42577c1ac37a5ee218310132d05d976a
https://doi.org/10.1164/rccm.200111-071oc

Ventilator-induced lung injury leads to loss of alveolar and systemic compartmentalization of tumor necrosis factor-α

Autor: Rolf Göggel, Burkhard Lachmann, Jack J. Haitsma, Stefan Uhlig, Ulrike Lachmann, Serge J. C. Verbrugge

Publikováno v: Intensive Care Medicine, 26, 1515-1522. Springer-Verlag
Intensive Care Medicine, 26(10), 1515-1522. Springer Verlag
Haitsma, J J, Uhlig, S, Göggel, R, Verbrugge, S J, Lachmann, U & Lachmann, B 2000, ' Ventilator-induced lung injury leads to loss of alveolar and systemic compartmentalization of tumor necrosis factor-α ', Intensive Care Medicine, vol. 26, no. 10, pp. 1515-1522 . https://doi.org/10.1007/s001340000648

Objectives: To determine the effect on compartmentalization of the tumor necrosis factor (TNF)-α response in the lung and systemically after ventilation with high peak inspiratory pressure with and without positive end-expiratory pressure (PEEP). De

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9b0ef51e2a6d5ee2e9d3be757b99f10
http://www.scopus.com/inward/record.url?scp=0033784084&partnerID=8YFLogxK

Development and characterisation of a novel and rapid lung eosinophil influx model in the rat

Autor: Andreas Westhof, Melanie Werner-Klein, Rolf Göggel, Klaus J. Erb

Publikováno v: Pulmonary pharmacologytherapeutics. 21(4)

Eosinophils play a major role in the development and severity of asthma. Robust and rapid preclinical animal models are desirable to profile novel therapeutics inhibiting the influx of eosinophils into the airways. To develop a rapid, airway eosinoph

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::add9ddea4d0e09948df43830efca02db
https://pubmed.ncbi.nlm.nih.gov/18490184

Mechanisms of platelet-activating factor (PAF)-mediated responses in the lung

Autor: Stefan, Uhlig, Rolf, Göggel, Stephanie, Engel

Publikováno v: Pharmacological reports : PR.

Platelet-activating factor (PAF) is a potent lipid mediator that has been implicated in asthma, sepsis, acute lung injury and ischemia/reperfusion injury. Its actions in the lungs include vasoconstriction, bronchoconstriction, and edema formation. De

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::5b92fe531382c54481535baf68cd1426
https://pubmed.ncbi.nlm.nih.gov/16415501