Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Rolando Perez-Pineiro"'
Autor:
Khaled H Barakat, Lars P Jordheim, Rolando Perez-Pineiro, David Wishart, Charles Dumontet, Jack A Tuszynski
Publikováno v:
PLoS ONE, Vol 7, Iss 12, p e51329 (2012)
BackgroundNucleotide excision repair (NER) removes many types of DNA lesions including those induced by UV radiation and platinum-based therapy. Resistance to platinum-based therapy correlates with high expression of ERCC1, a major element of the NER
Externí odkaz:
https://doaj.org/article/20ece2b4d4f641e686586a44680936bf
Publikováno v:
Energy & Fuels.
Autor:
Jody Hoshowski, Jonathan Hendry, Craig A. Peeples, Gabriel Hanna, Alyn Jenkins, Rolando Perez Pineiro
Publikováno v:
Industrial & Engineering Chemistry Research. 60:5394-5402
Raman spectroscopy is a rapid and noninvasive analytical technique used for the analysis of complex materials in complex matrices. Herein, we report for the first time a combined Raman-DFT study to assign all the vibrational modes associated with the
Autor:
Yeganeh, Khaniani, Matthias, Lipfert, Dipanjan, Bhattacharyya, Rolando, Perez Pineiro, Jiamin, Zheng, David S, Wishart
Publikováno v:
Metabolites
An improved method to synthesize the highly abundant and biomedically important urinary metabolite 3-(3-hydroxyphenyl)-3-hydroxypropionic acid (HPHPA) is reported. The modified protocol is based on an indium-mediated sonochemical Reformatsky reaction
Publikováno v:
MOJ Drug Design Development & Therapy. 2
Epigallocatechin gallate EGCG is a naturally occurring alkaloid found in green tea It has been shown to bind with nanomolar affinity to the monomeric prion protein and induce conformational instability A better understanding of the specific molecular
Autor:
Carol L. Ladner-Keay, Trent C. Bjorndahl, Li Ross, Lun Zhang, Rolando Perez-Pineiro, Neil R. Cashman, David S. Wishart
Publikováno v:
Prion. 12(5-6)
Prion diseases are caused by the conversion of normal cellular prion proteins (PrP) into lethal prion aggregates. These prion aggregates are composed of proteinase K (PK) resistant fibrils and comparatively PK-sensitive oligomers. Currently there are
Publikováno v:
European Journal of Medicinal Chemistry. 91:118-131
To understand the pharmacophore properties of 2-aminothiazoles and design novel inhibitors against the prion protein, a highly predictive 3D quantitative structure–activity relationship (QSAR) has been developed by performing comparative molecular
Autor:
Matthias Lipfert, Dipanjan Bhattacharyya, Rolando Perez Pineiro, David S. Wishart, Jiamin Zheng, Yeganeh Khaniani
Publikováno v:
Metabolites
Volume 8
Issue 4
Metabolites, Vol 8, Iss 4, p 80 (2018)
Volume 8
Issue 4
Metabolites, Vol 8, Iss 4, p 80 (2018)
An improved method to synthesize the highly abundant and biomedically important urinary metabolite 3-(3-hydroxyphenyl)-3-hydroxypropionic acid (HPHPA) is reported. The modified protocol is based on an indium-mediated sonochemical Reformatsky reaction
Autor:
Jack A. Tuszynski, Jonathan Y. Mane, Rolando Perez-Pineiro, Philip Winter, David S. Wishart, Valentyna Semenchenko
Publikováno v:
Chemical Biology & Drug Design. 82:60-70
The binding free energies on human tubulin of selected colchicine and thiocolchicine compounds were determined. Two methods were used for the determination of binding free energies: one is based on theoretical prediction simulating the dissociation o
Autor:
Augustin Scalbert, Philip Liu, Jianguo Xia, Trent C. Bjorndahl, Faizath S. Yallou, Roman Eisner, Michael Wilson, David Arndt, Yannick Djoumbou, Russell Greiner, Rolando Perez-Pineiro, Vanessa Neveu, Edison Dong, Rupasri Mandal, Felicity Allen, Yifeng Liu, Souhaila Bouatra, Timothy Jewison, Farid Aziat, David S. Wishart, Craig Knox, Igor Sinelnikov, An Chi Guo
Publikováno v:
Nucleic Acids Research
The Human Metabolome Database (HMDB) (www.hmdb.ca) is a resource dedicated to providing scientists with the most current and comprehensive coverage of the human metabolome. Since its first release in 2007, the HMDB has been used to facilitate researc