Výsledky vyhledávání - "Rolando Alberto Rodríguez-Fonseca"

Oportunidades de la epigenética como enfoque para el tratamiento del cáncer de mama

Autor: Rolando Alberto Rodríguez-Fonseca, Martha Edith Macías Pérez, Elvia Mera Jiménez, Maricarmen Hernández Rodríguez

Publikováno v: Revista Mexicana de Mastología. 10:93-97

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f4e6cc0d79501081d20e1f90b2ee81c6
https://doi.org/10.35366/99158

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In silico search, chemical characterization and immunogenic evaluation of amino-terminated G4-PAMAM-HIV peptide complexes using three-dimensional models of the HIV-1 gp120 protein

Autor: Jazmín García-Machorro, Manuel Jonathan Fragoso-Vázquez, João Rodrigues, Rolando Alberto Rodríguez-Fonseca, Nicolas Cayetano-Castro, María Ángeles Muñoz-Fernández, Saúl Rojas-Hernández, Raúl Borja-Urby, Jose L. Jimenez, Martiniano Bello, Mara Gutiérrez-Sánchez, José Correa-Basurto, Octavio Rodríguez-Cortés

Publikováno v: Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP

Peptide epitopes have been widely used to develop synthetic vaccines and immunotherapies. However, peptide epitopes may exhibit poor absorption or immunogenicity due to their low molecular weights. Conversely, fourth-generation polyamidoamine (G4-PAM

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48c8a23982a85ce7465b3d4dc5b17292
https://doi.org/10.1016/j.colsurfb.2019.01.034

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Complexation of peptide epitopes with G4-PAMAM dendrimer through ligand diffusion molecular dynamic simulations

Autor: Rolando Alberto Rodríguez-Fonseca, José Correa-Basurto, Martiniano Bello

Publikováno v: Journal of molecular graphicsmodelling. 96

Peptide epitopes from HIV-1 gp120 have been used to block the gp120-CD4 complex, whereas their poor absorbable or immunogenic properties prevent them from coupling to generation four polyamidoamine (PAMAM-G4) dendrimers. PAMAM-G4 are synthetic nanopa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26f830058606b606a5d1edb1cea8fcb8
https://pubmed.ncbi.nlm.nih.gov/31877401

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Dissecting the molecular recognition of dual lapatinib derivatives for EGFR/HER2

Autor: Concepción Guadarrama-García, Martiniano Bello, Rolando Alberto Rodríguez-Fonseca

Publikováno v: Journal of computer-aided molecular design. 34(3)

Abnormalities in the expression levels of EGFR/HER2 are found in many different types of human cancer; therefore, the design of dual inhibitors of EGFR/HER2 is a recognized anti-cancer strategy. Some lapatinib derivatives have been previously synthes

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe471d5404c8fcc51dbe350f3d5b79cd
https://pubmed.ncbi.nlm.nih.gov/31828486

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Complexation of methotrexate via ligand diffusion molecular dynamic simulations under neutral, basic, and acidic conditions

Autor: Rolando Alberto Rodríguez Fonseca, Martiniano Bello Ramirez, FERNANDO RODRIGUEZ DE FONSECA

Publikováno v: Journal of molecular graphicsmodelling. 93

Methotrexate (MTX), an FDA-approved drug employed in the treatment of several types of cancer and autoimmune diseases, is characterized by its poor solubility. Therefore, new strategies have been implemented such as coupling to nanocarriers to increa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15ea75ffba307a28276b8ea85c6a595e
https://pubmed.ncbi.nlm.nih.gov/31479949

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Searching the conformational complexity and binding properties of HDAC6 through docking and molecular dynamic simulations

Autor: José A. Gómez-Vidal, Martiniano Bello, Marlet Martínez-Archundia, Martha Cecilia Rosales-Hernández, Rolando Alberto Rodríguez-Fonseca, Yudibeth Sixto-López, José Correa-Basurto

Publikováno v: Journal of Biomolecular Structure and Dynamics. 35:2794-2814

Histone deacetylases (HDACs) are a family of proteins involved in the deacetylation of histones and other non-histones substrates. HDAC6 belongs to class II and shares similar biological functions with others of its class. Nevertheless, its three-dim

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7027052e8f28ec16ca2d547d7ffc7fbe
https://doi.org/10.1080/07391102.2016.1231084

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Binding free energy calculations using MMPB/GBSA approaches for PAMAM-G4-drug complexes at neutral, basic and acid pH conditions

Autor: João Rodrigues, Martiniano Bello, Rolando Alberto Rodríguez-Fonseca, Victor Armando Sánchez-Espinosa, Aurelio Romero-Castro, Alberto Martínez-Muñoz, José Correa-Basurto

Publikováno v: Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP

Dendrimers are synthetic macromolecules with a highly-branched structure and high concentration of surface groups. Among dendrimers, Poly(amidoamine) (PAMAM) has received substantial attention as a novel drug carrier and delivery system. Depending on

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6f5a07ae31fc9a5efd7962c7b57f6bf

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