Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Rolande Meudom"'
Autor:
Rolande Meudom, Yanxian Zhang, Michael A. VandenBerg, Lei Zou, Yi Wolf Zhang, Matthew J. Webber, Danny Hung-Chieh Chou
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 13, Iss 5, Pp 2281-2290 (2023)
Aggregation represents a significant challenge for the long-term formulation stability of insulin therapeutics. The supramolecular PEGylation of insulin with conjugates of cucurbit[7]uril and polyethylene glycol (CB[7]‒PEG) has been shown to stabil
Externí odkaz:
https://doaj.org/article/520b9d2dac8d4cbdaad4bf1c1ca309a0
Autor:
Fidele Ntie-Kang, Denis Zofou, Smith B Babiaka, Rolande Meudom, Michael Scharfe, Lydia L Lifongo, James A Mbah, Luc Meva'a Mbaze, Wolfgang Sippl, Simon M N Efange
Publikováno v:
PLoS ONE, Vol 8, Iss 10, p e78085 (2013)
Computer-aided drug design (CADD) often involves virtual screening (VS) of large compound datasets and the availability of such is vital for drug discovery protocols. We assess the bioactivity and "drug-likeness" of a relatively small but structurall
Externí odkaz:
https://doaj.org/article/85357b95def44bc49e698dff96a524f4
Autor:
Zachary S. Clauss, Rolande Meudom, Bo Su, Michael A. VandenBerg, Simranpreet S. Saini, Matthew J. Webber, Danny Hung-Chieh Chou, Jessica R. Kramer
Publikováno v:
Biomacromolecules. 24:481-488
Protein aggregation is an obstacle for the development of new biopharmaceuticals, presenting challenges in shipping and storage of vital therapies. Though a variety of materials and methods have been explored, the need remains for a simple material t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01caf39ef3ff3a8820311b400111113d
https://doi.org/10.1021/acs.biomac.2c01319
https://doi.org/10.1021/acs.biomac.2c01319
Autor:
Rolande Meudom, Danny Hung-Chieh Chou, Shugao Zhu, Michael T. Jacobsen, Liping Cao, Nan Zheng
Publikováno v:
Current Research in Chemical Biology, Vol 2, Iss, Pp 100013-(2022)
Cucurbit[7]uril (CB[7]) is a supramolecular binding host for peptides and proteins with N-terminal Phe. However, the low occurrence of such peptides and proteins limits broader applications of this unique host-guest interaction. Here, we report a str
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e86f1cc891457964ae1e5b7353d3df6f
http://www.sciencedirect.com/science/article/pii/S2666246921000136
http://www.sciencedirect.com/science/article/pii/S2666246921000136
Publikováno v:
The Journal of organic chemistry. 83(17)
The synthesis of 1,2,4,5- and 1,2,9,10-tetrasubstituted and 1,2,4,5,8-pentasubsutituted pyrenes has been achieved by initially functionalizing the K-region of pyrene. Bromination, acylation, and formylation reactions afford high to moderate levels of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00a50c1fbada640523d2c62653b15594
https://pubmed.ncbi.nlm.nih.gov/29920094
https://pubmed.ncbi.nlm.nih.gov/29920094
Publikováno v:
Organic Letters. 17:2700-2703
A new synthetic strategy that employs a relatively unstrained, 1,4-diketo-bridged macrocycle as a precursor to a strained, 1,4-arene-bridged (bent para-phenylene) macrocycle has been developed. The distorted p-terphenyl nucleus (CPP fragment) of the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::860b293d9f783c0780d98c497f85f07a
https://doi.org/10.1021/acs.orglett.5b01102
https://doi.org/10.1021/acs.orglett.5b01102
Publikováno v:
Journal of the American Chemical Society. 138(9)
A series of p-terphenyl-based macrocycles, containing highly distorted p-phenylene units, have been synthesized. Biaryl bonds of the nonplanar p-terphenyl nuclei were constructed in the absence of Pd-catalyzed or Ni-mediated cross-coupling reactions,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f30c207a62788484e9ff3814f7dd17ea
https://pubmed.ncbi.nlm.nih.gov/26866502
https://pubmed.ncbi.nlm.nih.gov/26866502
Autor:
Michael Scharfe, Simon M. N. Efange, Smith B. Babiaka, Wolfgang Sippl, James A. Mbah, Rolande Meudom, Luc Meva'a Mbaze, Denis Zofou, Lydia L. Lifongo, Fidele Ntie-Kang
Publikováno v:
PLoS ONE
PLoS ONE, Vol 8, Iss 10, p e78085 (2013)
PLoS ONE, Vol 8, Iss 10, p e78085 (2013)
Computer-aided drug design (CADD) often involves virtual screening (VS) of large compound datasets and the availability of such is vital for drug discovery protocols. We assess the bioactivity and “drug-likeness” of a relatively small but structu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35412b138abb86a9b91289fec60cb57c
https://pubmed.ncbi.nlm.nih.gov/24205103
https://pubmed.ncbi.nlm.nih.gov/24205103