Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Rolande Dupuis"'
Autor:
Jean-Claude Mazière, D. Citadelle, M. Repetto, M. Meier, S. Biade, Charles Roux, Rolande Dupuis, D. Quiec
Publikováno v:
Teratology. 42:611-618
AY 9944 [trans-1,4-bis(2-chlorobenzylaminomethyl) cyclohexane dihydrochloride] is an amphiphilic cationic molecule. This chemical is an established inhibitor of cholesterol synthesis and is teratogenic in rats. The mechanisms of this teratogenicity r
Publikováno v:
Teratology. 19:39-43
Cholesterol synthesis inhibitors administered to rats caused more or less complete forms of the holoprosencephalic syndrome, consisting of severe abnormalities of the brain, sense organs and pituitary. The absence of the pituitary was also observed i
Autor:
Cécile Mazière, Rolande Dupuis, Danièle Lambert, Charles Roux, Elisabeth Elefant, Jean-Claude Mazière, Jacques Polonovski, Véronique Barbu, Jean Gardette
Publikováno v:
The Journal of Nutrition. 118:774-779
These studies were conducted to determine whether dietary cholesterol supplementation could prevent fetal malformations induced by the amphipathic drug AY 9944, which is well known as a cholesterol biosynthesis inhibitor, and to investigate whether t
Publikováno v:
Teratology. 19:35-38
Embryomortality and teratogenesis provoked by inhibitors of cholesterol synthesis are well demonstrated. Teratogenic action is particularly reflected by holoprosencephalies, but also by uro-genital abnormalities. A hypercholesterolemia-provoking diet
Publikováno v:
Neonatology. 4:371-378
Autor:
Rolande Dupuis, S. Talanti, Sidney Q. Cohlan, Walter Tkaczyk, I. A. Mochtar, U.K. Rinne, P. Fournier, Monika Brück, Lyndon A. Peer, William G. Bernhard, J.G. Koppe, Kurt Brück, G.J. Kloosterman, C. Roux, Gerrit Bevelander, E. Kivalo, Y. Dupuis, S. von Creveld, Arthur H. Parmelee, Harry W. Gordon
Publikováno v:
Neonatology. 4:I-IV
Publikováno v:
The Journal of Nutrition. 110:2310-2312
The teratogenic action of AY 9944, an inhibitor of cholesterol synthesis, was previously shown. Its prevention by simultaneous administration of cholesterol led to the hypothesis that this action is correlated with the decrease in cholesterol. The pr
Publikováno v:
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.). 176(1)
An inhibitor of cholesterol synthesis, AY 9944 (trans-1,4-bis(2-chlorobenzylaminomethyl) cyclohexane dihydrochloride) is teratogenic. A single dose of AY 9944 (50 mg/kg or 75 mg/kg) given to Wistar pregnant rats on the second, fourth, sixth, seventh,
Publikováno v:
Radiation Research. 108:317
Pregnant Wistar rats were exposed to either microwave-induced hyperthermia or gamma radiation or a combination of both. In microwave-induced hyperthermia, a core temperature of 42 degrees C was slightly teratogenic and a core temperature greater than