Zobrazeno 1 - 10
of 114
pro vyhledávání: '"Roland T Ullrich"'
Autor:
Florian Malchers, Lucia Nogova, Martijn H.A. van Attekum, Lukas Maas, Johannes Brägelmann, Christoph Bartenhagen, Luc Girard, Graziella Bosco, Ilona Dahmen, Sebastian Michels, Clare E. Weeden, Andreas H. Scheel, Lydia Meder, Kristina Golfmann, Philipp Schuldt, Janna Siemanowski, Jan Rehker, Sabine Merkelbach-Bruse, Roopika Menon, Oliver Gautschi, Johannes M. Heuckmann, Elisabeth Brambilla, Marie-Liesse Asselin-Labat, Thorsten Persigehl, John D. Minna, Henning Walczak, Roland T. Ullrich, Matthias Fischer, Hans Christian Reinhardt, Jürgen Wolf, Reinhard Büttner, Martin Peifer, Julie George, Roman K. Thomas
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 21 (2023)
The discovery of frequent 8p11-p12 amplifications in squamous cell lung cancer (SQLC) has fueled hopes that FGFR1, located inside this amplicon, might be a therapeutic target. In a clinical trial, only 11% of patients with 8p11 amplification (detecte
Externí odkaz:
https://doaj.org/article/ef6247e9f6b84dbca5a0844486ed3d80
Autor:
Jan-Michel Heger, Julia Mattlener, Laman Mammadova, Sophia Sobesky, Melita Cirillo, Janine Altmüller, Elisabeth Kirst, Sarah Reinke, Wolfram Klapper, Paul J Bröckelmann, Justin Ferdinandus, Roland T Ullrich, Max Freihammer, Sabine Awerkiew, Mia Lohmann, Florian Klein, Peter Nürnberg, Michael Hallek, Andreas Engert, Peter Borchman, Bastian von Tresckow, Sven Borchmann
Publikováno v:
HemaSphere, Vol 7, p e8618132 (2023)
Externí odkaz:
https://doaj.org/article/79607bef1f9e47c8b135e818f59cfcd8
Autor:
Johannes Brägelmann, Carina Lorenz, Sven Borchmann, Kazuya Nishii, Julia Wegner, Lydia Meder, Jenny Ostendorp, David F. Ast, Alena Heimsoeth, Takamasa Nakasuka, Atsuko Hirabae, Sachi Okawa, Marcel A. Dammert, Dennis Plenker, Sebastian Klein, Philipp Lohneis, Jianing Gu, Laura K. Godfrey, Jan Forster, Marija Trajkovic-Arsic, Thomas Zillinger, Mareike Haarmann, Alexander Quaas, Stefanie Lennartz, Marcel Schmiel, Joshua D’Rozario, Emily S. Thomas, Henry Li, Clemens A. Schmitt, Julie George, Roman K. Thomas, Silvia von Karstedt, Gunther Hartmann, Reinhard Büttner, Roland T. Ullrich, Jens T. Siveke, Kadoaki Ohashi, Martin Schlee, Martin L. Sos
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Kinase inhibitors are widely used to treat cancer, however patients frequently develop resistance. Here, the authors investigate adaption mechanisms during drug persistence and show that stimulation of the innate immunity sensor RIG-I enhances cancer
Externí odkaz:
https://doaj.org/article/9def69d01bbd4809814653393e15ac1f
Autor:
Reinhard Büttner, Khosro Hekmat, David Kirsch, Michael Hallek, Birgit Gathof, Jana Fassunke, Asmae Gassa, Hakan Alakus, Sven Borchmann, Carolin Selenz, Mia Lohmann, Hanna Ludwig, Johannes Brägelmann, Philipp Lohneis, Lydia Meder, Julia Mattlener, Sara Breid, Marieke Nill, Amy J. Wisdom, Anik Compes, H. Christian Reinhardt, Roland T. Ullrich
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 10, Iss 10 (2022)
Background Single-agent immunotherapy has shown remarkable efficacy in selected cancer entities and individual patients. However, most patients fail to respond. This is likely due to diverse immunosuppressive mechanisms acting in a concerted way to s
Externí odkaz:
https://doaj.org/article/3195db6b915d4f2596d994cb921be8a5
Autor:
Melanie J. Mittenbühler, Katarzyna Saedler, Hendrik Nolte, Lara Kern, Jun Zhou, Shu-Bing Qian, Lydia Meder, Roland T. Ullrich, Jens C. Brüning, F. Thomas Wunderlich
Publikováno v:
Molecular Metabolism, Vol 42, Iss , Pp 101085- (2020)
Objective: Single-nucleotide polymorphisms in the FTO gene encoding an m6Am and an m6A demethylase are associated with obesity. Moreover, recent studies have linked a dysregulation of m6A modifications and its machinery, including FTO, to the develop
Externí odkaz:
https://doaj.org/article/94aae171be7140c5bfb4613a037c4e19
Autor:
Caroline Volz, Sara Breid, Carolin Selenz, Alina Zaplatina, Kristina Golfmann, Lydia Meder, Felix Dietlein, Sven Borchmann, Sampurna Chatterjee, Maike Siobal, Jakob Schöttle, Alexandra Florin, Mirjam Koker, Marieke Nill, Luka Ozretić, Niklas Uhlenbrock, Steven Smith, Reinhard Büttner, Hui Miao, Bingcheng Wang, H. Christian Reinhardt, Daniel Rauh, Michael Hallek, Amparo Acker-Palmer, Lukas C. Heukamp, Roland T. Ullrich
Publikováno v:
Cell Reports, Vol 31, Iss 4, Pp - (2020)
Summary: Anti-angiogenic treatment targeting vascular endothelial growth factor (VEGF)-VEGFR2 signaling has shown limited efficacy in lung cancer patients. Here, we demonstrate that inhibition of VEGFR2 in tumor cells, expressed in ∼20% of non-squa
Externí odkaz:
https://doaj.org/article/facb3169b7084c8eb4f67f107da06c75
Autor:
Roman K. Thomas, Yasushi Yatabe, Stefan A. Haas, Sascha Ansén, Sven Perner, Jürgen Wolf, Thomas Zander, Reinhard Buettner, Lukas C. Heukamp, Martin Vingron, Dirk Brehmer, Marc Parade, Souichi Ogata, Timothy Perera, Idoya Lahortiga, Vito M. Fazio, Annamaria la Torre, Lucia A. Muscarella, Jörg Sänger, Joachim H. Clement, Iver Petersen, Erich Stoelben, Johannes M. Heuckmann, Peter Nürnberg, Christian Becker, Janine Altmüller, Sylvie Lantuejoul, Christian G. Brambilla, Denis Moro-Sibilot, Hélène Nagy-Mignotte, Elisabeth Brambilla, Benjamin Solomon, Zoe Wainer, Prudence A. Russell, Gavin M. Wright, Roland T. Ullrich, Mirjam Koker, Ilona Dahmen, Wenzel Vogel, Jakob Schöttle, Florian Malchers, Juliane Daßler, Marc Bos, Martin Peifer, Sandra Ortiz-Cuaran, Frauke Leenders, Roopika Menon, Ruping Sun, Hirotaka Osada, Dennis Plenker, Lynnette Fernandez-Cuesta
XLSX file 75K, This is an excel file containing 9 sheets, one for each of the 9 supplementary tables (S1 to S9) mentioned in the main text
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1f2683ba8a868adc9f8a76d6605235a
https://doi.org/10.1158/2159-8290.22530114.v1
https://doi.org/10.1158/2159-8290.22530114.v1
Autor:
Roman K. Thomas, Yasushi Yatabe, Stefan A. Haas, Sascha Ansén, Sven Perner, Jürgen Wolf, Thomas Zander, Reinhard Buettner, Lukas C. Heukamp, Martin Vingron, Dirk Brehmer, Marc Parade, Souichi Ogata, Timothy Perera, Idoya Lahortiga, Vito M. Fazio, Annamaria la Torre, Lucia A. Muscarella, Jörg Sänger, Joachim H. Clement, Iver Petersen, Erich Stoelben, Johannes M. Heuckmann, Peter Nürnberg, Christian Becker, Janine Altmüller, Sylvie Lantuejoul, Christian G. Brambilla, Denis Moro-Sibilot, Hélène Nagy-Mignotte, Elisabeth Brambilla, Benjamin Solomon, Zoe Wainer, Prudence A. Russell, Gavin M. Wright, Roland T. Ullrich, Mirjam Koker, Ilona Dahmen, Wenzel Vogel, Jakob Schöttle, Florian Malchers, Juliane Daßler, Marc Bos, Martin Peifer, Sandra Ortiz-Cuaran, Frauke Leenders, Roopika Menon, Ruping Sun, Hirotaka Osada, Dennis Plenker, Lynnette Fernandez-Cuesta
PDF file 234K, This is a file containing the list of supplementary tables, the list of supplementary figures, as well as the 7 supplementary figures (S1 to S7) and their correspondent legends, mentioned in the main text
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::000f05e4cc23df9c591b388d0865f7bb
https://doi.org/10.1158/2159-8290.22530117
https://doi.org/10.1158/2159-8290.22530117
Autor:
Roman K. Thomas, Jürgen Wolf, Lukas C. Heukamp, Reinhard Büttner, Francois Ringeisen, H. Christian Reinhardt, Roland T. Ullrich, Thomas Zander, Daniel Rauh, Steffi Silling, Julie George, Srivari Chandrasekhar, Nagaraju Karre, Prathama S. Mainkar, Alexandra Florin, Martin Peifer, André Richters, Frauke Leenders, Danila Seidel, Marc Bos, Matthias Scheffler, Masyar Gardizi, Dennis Plenker, Joachim Diebold, Oliver Gautschi, Johannes M. Heuckmann, Lynnette Fernandez-Cuesta, Kerstin Albus, Lucia Nogova, Xin Lu, Jakob Schöttle, Felix Dietlein, Florian Malchers
PDF file 136K,Methods: Additional information on experimental techniques and data analysis. Legends: describing supplementary figures S1-S14
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad5cc41fa20095c9341ef451390a6d5f
https://doi.org/10.1158/2159-8290.22529610
https://doi.org/10.1158/2159-8290.22529610
Autor:
Roman K. Thomas, Jürgen Wolf, Lukas C. Heukamp, Reinhard Büttner, Francois Ringeisen, H. Christian Reinhardt, Roland T. Ullrich, Thomas Zander, Daniel Rauh, Steffi Silling, Julie George, Srivari Chandrasekhar, Nagaraju Karre, Prathama S. Mainkar, Alexandra Florin, Martin Peifer, André Richters, Frauke Leenders, Danila Seidel, Marc Bos, Matthias Scheffler, Masyar Gardizi, Dennis Plenker, Joachim Diebold, Oliver Gautschi, Johannes M. Heuckmann, Lynnette Fernandez-Cuesta, Kerstin Albus, Lucia Nogova, Xin Lu, Jakob Schöttle, Felix Dietlein, Florian Malchers
PDF file 34156K, Table of genes from 16 recurrent amplified genomic regions (Figure S1), amplicon focality on TCGA copy number aberrations (Figure S2), hierarchical clustering of CLCGP copy number data (Figure S3), centrality frequencies of common ca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aaa55b970728bba259689298cf12daa2
https://doi.org/10.1158/2159-8290.22529613
https://doi.org/10.1158/2159-8290.22529613